2HXP,1MKP,4Y2E


Conserved Protein Domain Family
DSP_MKP_classII
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cd14566: DSP_MKP_classII 
dual specificity phosphatase domain of class II mitogen-activated protein kinase phosphatase
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are eukaryotic dual-specificity phosphatases (DUSPs) that act on MAPKs and function as a protein-serine/threonine phosphatase (EC 3.1.3.16) and a protein-tyrosine-phosphatase (EC 3.1.3.48). They deactivate MAPKs by dephosphorylating the threonine and tyrosine residues in the conserved Thr-Xaa-Tyr motif residing in their activation sites. Based on sequence homology, subcellular localization and substrate specificity, 10 MKPs can be subdivided into three subfamilies (class I-III). Class II MKPs consist of DUSP6/MKP-3, DUSP7/MKP-X and DUSP9/MKP-4, and are ERK-selective cytoplasmic MKPs. All MKPs contain an N-terminal Cdc25/rhodanese-like domain, which is responsible for MAPK-binding, and a C-terminal catalytic dual specificity phosphatase domain.
Links
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Statistics
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PSSM-Id: 350414
Aligned: 17 rows
Threshold Bit Score: 249.543
Created: 30-Sep-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:x x C x x x x x RClick to see conserved feature residue pattern help
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    #                                           #                       
2HXP_A         6 PVQILP-NLYLGSardsANLESLAKLgIRYILNVTpnlpnffekngDFHYKQIPISDHwsqNLSRFFPEAIEFIDEalsq 84  human
XP_794377    185 PAQILP-YLYLGTkqdcENFELFSKLrIRYVLNVTpnipn-cfednGIKYMQIPIMDHwsqNLAAFFPEAIEFIDEarra 262 purple urchin
XP_002158119 185 PIEILP-QLFLGNktdsSCIDLLRKFnITHILNVThdlpnlfyeskEFEYLQIPIQDNstgNVLDMFPIAYKFIENaida 263 green hydra
XP_001637495 186 LAEILP-RLYLGSekdaSNIELLRKHkISYVLNVThdrpntfahieGFKYKNLPVEDNlmaNLTELFPEAFAFIDEgrqk 264 starlet sea ane...
NP_001071938 301 PAEILN-GLFLGCakdaSNAAVLAEHnITYILNVTpnlpnvfendgKYKYKQIPITDHwsqNLSQFFPDAIAFIDEarsk 379 Ciona intestinalis
XP_002403453 216 PVQIVP-FLFLGNeensTDLEALERNnIRYVLNVThnlan-tfeghGFKYMKIPIEDHwsqNLASFFPQAIAFIDEarqk 293 black-legged tick
AAO39540      94 PVEIIPgLLFLGNathsCDSEALKKYnIKYVLNVTpdlpnkfkesgDIKYLQIPITDHysqDLAIHFPDAIQFIEEarsa 173 fruit fly
4Y2E_A         6 PVQILP-YLYLGCakdsTNLDVLGKYgIKYILNVTpnlpnafehggEFTYKQIPISDHwsqNLSQFFPEAISFIDEarsk 84  human
XP_002738179 182 PVEILP-YLFLGSaqdsKNIEKLSKHgIKYILNVTpnipnrferdgEFKYMQIPINDHwsqNLSAFFPEAIEFIEEarqa 260 Saccoglossus ko...
EFX75616     185 PVEILP-HLFLGNaqnsRDCDALDKHrIRYVVNVTpnlpnvfedsgTIQYLQIPITDHwsqNLASFFPSAIGFIDGarer 263 common water flea

Feature 1               #######                                            
2HXP_A        85 ncGVLVHSLAGVSRSVTVTVAYLMQKlhlsLNDAYDLVKRKKSNISPNFNFMGQLLDF 142 human
XP_794377    263 ksGILVHCLAGVSRSVTVTVAYLMQKlclsLNDAYDFVKERKSNISPNFNFMGQLKDF 320 purple urchin
XP_002158119 264 ggCVLVHCLGGISRSSTIIIAYLMIKyrfsLNEAYDHVKSKKRNIAPNFTFMGQLLDL 321 green hydra
XP_001637495 265 ssNVLVHCLAGISRSVTITIAYLMSSqhlsLNEAYDFVKARKSNVSPNFNFMGQLLDF 322 starlet sea anemone
NP_001071938 380 ncGVLVHCLAGISRSVTVTVAYLMQKlrwsLNDAYDFVKQRKNNVSPNFNFMGQLLDF 437 Ciona intestinalis
XP_002403453 294 rvGVLVHCLAGVSRSVTVTLAYLMQKqklpLNDAYDLVKKRKANIAPNFNFLGQLLDF 351 black-legged tick
AAO39540     174 ssVVLVHCLAGVSRSVTVTLAYLMHTrglsLNDAFAMVRDRKPDVSPNFHFMQQLLSF 231 fruit fly
4Y2E_A        85 kcGVLVHSLAGISRSVTVTVAYLMQKmnlsLNDAYDFVKRKKSNISPNFNFMGQLLDF 142 human
XP_002738179 261 kcGILVHCLAGISRSVTVTVAYLMQKlawsLNDAYDYVKKKKENISPNFNFMGQLLDF 318 Saccoglossus kowalevskii
EFX75616     264 qeGVLVHCLAGISRSVTITVAYLMYKmsmsLNDAYDFVRRKKSNISPNFNFMGQLLDF 321 common water flea

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