2JV0,2QPW


Conserved Protein Domain Family
PR-SET_PRDM2
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cd19188: PR-SET_PRDM2 
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins
PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.
Links
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Statistics
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PSSM-Id: 380965
Aligned: 11 rows
Threshold Bit Score: 188.034
Created: 11-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putative activeputative SAMcatalytic
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Mus musculus PRDM9 (4C1Q) binds H3k4me2 and S-adenosylhomocysteine (AdoHcy) through its PR-SET domain.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                             ##                #          ## #####          #            
2JV0_A         25 LRGLPEEVRLFPSAVdk--tRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPn-LGWMCIDATDPeKGNWL 101  human
2QPW_A         24 LRGLPEEVRLFPSAVdk--tRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPn-LGWMCIDATDPeKGNWL 100  human
NP_001088018   23 LRGLPEELRLAPSAVdn--rRLGVWARKQVQRGKKFGPFVGEKKKRSQVKNNVFMWEVYYPn-LGWMCVDATDPqKGNWL 99   African clawe...
CAG07019       19 WKGLPDGLSLAPSAVhq--sRVGVWATRLIPKGRRFGPFAGEKKKRSQVTSNVYMWEVYFPa-RGWMCVDATDPtKGNWL 95   spotted green...
KYO20475       23 LKGLPEEVRLFPSAVdk--tRLGVWATKSILKGKKFGPFLGDKKKRSQVKSNVYMWEVYYPn-LGWMCVDATDPkKGNWL 99   American alli...
Q13029         23 LRGLPEEVRLFPSAVdk--tRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPn-LGWMCIDATDPeKGNWL 99   human
EEN66909       61 SMVIPAELEVKRSGVs---tKNGVWCKRSIPKSVKYGPFKGEKKKKSQVTNPDYMWEIRTG--KGWFCVDASDPtKGNWM 135  Florida lancelet
XP_006005240   23 HKGLPEELSLRQSAIde--aRVGVWAAKSIPKGKKFGPFVGERKKRSQVKSNVYMWEVYYPn-WGWMCIDATDPkKGNWL 99   coelacanth
XP_002741726   16 DMKIPVAFEFKPSIVed--nKIGVWTKTLIKEGTLYGPYGGEKKKIQDHCDPYYSWEIRGPkgRRLFCIDASDPkKSNWL 93   Saccoglossus ...
XP_003724630    8 GIKAPSGLEFRQSQMep--tLVGVWAKRSVRKGRTFGPFIGERRDCSDVLDDTYSWEIRGPkgVRLYSVDASEPtKANWM 85   purple sea ur...
PIK35802        8 SSVIPHHLLLPNIPFakyrpIIGVFSRKQVNRGRLYGPFKGERKRCSEVINDTYSWQIIGPkgRRLFCVDASDAsKGNWM 87   Japanese sea ...

Feature 1         ##### #        ##                       #     
2JV0_A        102 RYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYXGEDN 147  human
2QPW_A        101 RYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 146  human
NP_001088018  100 RYVNWARSAKEQNLCSLEINRAIYYKTLKPIEPGEELLVWYNGEDN 145  African clawed frog
CAG07019       96 RYVNWARSSQEQNLFPLEINRAVYYKVLRPIGPGEELLVWYTVEDN 141  spotted green pufferfish
KYO20475      100 RYVNWARSGKEQNLFPLEINRTIYYKTLKPIEPGQELLVWYNGEDN 145  American alligator
Q13029        100 RYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDN 145  human
EEN66909      136 RYVNSARYFEEQNIVALQQHQRIYYKTIKEIKPGEELLCWFNSSDT 181  Florida lancelet
XP_006005240  100 RYVNWARSGEEQNLFPLEINRAVYYKALKPIEPGEELLVWYNGEDN 145  coelacanth
XP_002741726   94 RYIKVARYYEEQNMVANQQNKQIYYKTIKDIKPDEELLCWFNILSE 139  Saccoglossus kowalevskii
XP_003724630   86 RYVKSARSFEEQNMIATQYKRSIYYRTLRPIAVGEELMCWYKNLSP 131  purple sea urchin
PIK35802       88 RFVKTAPGKDLHNLHPVQHKKKIYYKVIKTIAIGTELLCWYEGATD 133  Japanese sea cucumber

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