4B8T,2HH3,2JVZ


Conserved Protein Domain Family
KH-I_FUBP2_rpt3

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cd22485: KH-I_FUBP2_rpt3 
third type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 2 (FUBP2) and similar proteins
FUBP2, also called FUSE-binding protein 2, or KH type-splicing regulatory protein (KSRP), or p75, is a single-strand nucleic acid binding protein implicated in a variety of cellular processes, including splicing in the nucleus, mRNA decay, maturation of miRNA, and transcriptional control of proto-oncogenes such as c-myc. It regulates the stability and/or translatability of many mRNA species, encoding immune-relevant proteins, either by binding to AU-rich elements (AREs) of mRNA 3'UTR or by facilitating miRNA biogenesis to target mRNA. FUBP2 contains four K-homology (KH) RNA-binding domains. The model corresponds to the third one.
Statistics
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PSSM-Id: 411913
Aligned: 9 rows
Threshold Bit Score: 125.456
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA bindingGXXG motif
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4B8T: Homo sapiens FUBP2 in complex with the G-rich target sequence; contacts at 4A
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ###### #####  ##  #     ####         #                      
4B8T_A        11 GGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLL 78  human
2HH3_A        11 GGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLL 78  human
2JVZ_A        91 GGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLL 158 human
AAN77160     277 GGIDVPVPRHSVGVVIGRSGDMIKKIQNDAGVRIQFKQDDGTGPDKIAHIMGPPDRCEHAASIISDLL 344 African clawed frog
NP_989608    386 GGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPERCEHAARIINDLL 453 chicken
Q92945       323 GGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLL 390 human
XP_014348580 319 GGIDVPVPRHSVGVVIGRNGEMIKKIQSDAGVRIQFKPDDGTGPEKIAHIMGPPDRCEHAARIINDLL 386 coelacanth
AAI39702     294 GGIEVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKPDDGTGPDKIAHIMGPPDRCEHAASIINELL 361 zebrafish
XP_007905349 312 GGIDIPVPRHSVGIVIGRSGEMIKKIQNDAGVRIQFKPDDGTTPDKIAHVMGPPERCQHAAQIISDLL 379 elephant shark

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