2H8N


Conserved Protein Domain Family
ClassIIa_HDAC4_Gln-rich-N
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cd10162: ClassIIa_HDAC4_Gln-rich-N 
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Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
This family consists of the glutamine-rich domain of histone deacetylase 4 (HDAC4). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.
Links
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Statistics
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PSSM-Id: 197398
Aligned: 4 rows
Threshold Bit Score: 77.16
Created: 26-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 35 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:four copies of HDAC4 form a four-helix bundle
  • Comment:The interactions of each helix with its neighboring three helices are the same for all four helices due to the D2 point group symmetry.
  • Structure:2H8N: human histone deacetylase 4 (HDAC4) glutamine-rich region, tetramer interface; contacts at 4.0A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ## ##  #   #  ##  ## ##  ## ##  ### ### ## ### ##  #  ##  ###                  
2H8N_A         22 EPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKqQQEMLAMKHQQELLEHQRKLERHRQEQE 101  human
NP_001034447   33 DPAQREHQLQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKhQQDLLALKHQQELLEHQRKLGRHRQEQE 112  zebrafish
NP_989644      63 EPTLREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIK-QQEMLAMKHQQELLEHQRKLEQHRQEQE 141  chicken
XP_002932071   82 EPGGREQQLQQELLALKQKQQIQRQLLIAEFQRQHEQLSRQHEAQLHEHIKqQQELLAMKHQQELLEHQRKLEQHRQEQE 161  western clawe...

Feature 1                   
2H8N_A        102 LEKQHREQKL 111  human
NP_001034447  113 MEKQQREQKL 122  zebrafish
NP_989644     142 LEKQHREQKL 151  chicken
XP_002932071  162 MEKQQREQKL 171  western clawed frog

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