4LIJ,1X4N


Conserved Protein Domain Family
KH-I_FUBP1_rpt1
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cd22478: KH-I_FUBP1_rpt1 
first type I K homology (KH) RNA-binding domain found in far upstream element-binding protein 1 (FUBP1) and similar proteins
FUBP1, also called FBP, or FUSE-binding protein 1, or DNA helicase V, or DH V, binds RNA and single-stranded DNA (ssDNA) and may act both as activator and repressor of transcription. It regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. FUBP1 contains four K-homology (KH) RNA-binding domains. The model corresponds to the first one.
Links
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Statistics
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PSSM-Id: 411906
Aligned: 7 rows
Threshold Bit Score: 133.995
Created: 18-Jul-2020
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # ### #####  ##  ##    ####                                    
4LIJ_A        13 RSVXTEEYKVPDGXVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCXLTGTPESVQSAKRLLDQIVEKGR 87  human
1X4N_A        12 RSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGR 86  house mouse
CAG32683      95 RSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGR 169 chicken
XP_007885441  87 RSIATEEYKVPDSMVGFIIGRGGEQISRIQQESGCKVQIAPDSGGLPERSCMLTGSPDSIQAAKRLLDQIVERGR 161 elephant shark
XP_014345677  91 RSVMTEEYKIPDGMVGFIIGRGGEQISRIQQDSGCKIQIAPDSGGLPERSCMLTGTPESVQAAKRLLDQIVEKGR 165 coelacanth
Q96AE4        98 RSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGR 172 human
Q6P3Q5        86 RSVVTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGMPDRSCMLTGSPDSVQAAKRLLDQIVEKGR 160 tropical clawed frog

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