4NYH,1YN9


Conserved Protein Domain Family
DSP_DUSP11
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cd17665: DSP_DUSP11 
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dual-specificity phosphatase domain of dual specificity protein phosphatase 11 and similar proteins
dual specificity protein phosphatase 11 (DUSP11), also known as RNA/RNP complex-1-interacting phosphatase or phosphatase that interacts with RNA/RNP complex 1 (PIR1), has RNA 5'-triphosphatase and diphosphatase activity, but only poor protein-tyrosine phosphatase activity. It has activity for short RNAs but is less active toward mononucleotide triphosphates, suggesting that its primary function in vivo is to dephosphorylate RNA 5'-ends. It may play a role in nuclear mRNA metabolism. Also included in this subfamily is baculovirus RNA 5'-triphosphatase for Autographa californica nuclear polyhedrosis virus.
Links
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Statistics
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PSSM-Id: 350503
Aligned: 16 rows
Threshold Bit Score: 259.901
Created: 19-Jun-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 9 residue positions
Conserved feature residue pattern:C x x x x x R x xClick to see conserved feature residue pattern help
Evidence:
  • Structure:4NYH: Human PIR1 binds a phosphate ion in the active site; contacts at 4A
    - View structure with Cn3D
  • Comment:the conserved histidine and asparagine in the active site loop are defining features of atypical DSPs that specialize in dephosphorylating 5'-RNA
  • Comment:also based on structures of cys-based phosphatase superfamily members with bound substrates (both peptide and non-peptide)
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
4NYH_A        11 RWKDYLPVGQRMpg-tRFIAFKVPLQKSFekkl-----apeeCFSPLDLFNKIREqneeLGLIIDLTYTQRYYKPEDLPE 84  human
1YN9_A         6 RWHNYLQCGQVIkd-sNLICFKTPLRPELfayvt----seedVWTAEQIVKQNPS----IGAIIDLTNTSKYYDGVHFLR 76  Autographa cali...
NP_610696      8 RWLKYKPIGDRVpg-tRFIAFKVPLNQHVnakv-----kenlRLAPESLLQIVPD----MGLIIDLTNTNRYYHPSAITN 77  fruit fly
EFO18445      32 RWIDYDPVGKDMpg-tRFVAFKTPLRHSYflnrgd-efdvenIFETKNLLHMANAagkqIGLVIDLTATTKYYDPREWTD 109 Loa loa
XP_002736003  10 RWESYVPVGKPVag-tRIFAFKVPLRDGIannlt----eedqYFGPSELFEEVEKtghkLGLVIDLTNTARYYDSKDITK 84  Saccoglossus ko...
XP_001639672   1 RWRDYSTCNWTPiegqRIIIFKTPLSNVN-------------MFTPTDLIEQLAQremkLGLVLDFTFTTRYYDPREFTA 67  starlet sea ane...
NP_001036968   7 RWIKYNACGRVIeg-tRIICFKVPLSKSQqvqks----qvkkIWDIPALLEAIPK----LGAVIDLTNTDKYYKPEDVKA 77  domestic silkworm
XP_002126475   7 RWLDYEKMGQVIeg-tDILAMKVPLYEGItrnl-----pkkeHFNWKIAVDTAEErghrIGTVVDLTYSTRYYQPRDFTN 80  Ciona intestinalis
NP_495959     28 RWNIYDNVGRDIdg-tRFVPFKTPLDSSFfdgknmpvelqfgVKTLISLAQQANKq---IGLVIDLTNTDRYYKKTEWAD 103 Caenorhabditis ...
NP_001254988  11 DWSKFQPVGNVIpr-tRFIVFKTPINSQLstki-----hkeqRFTTNDLFRQLSErgqyLGLVVDLSDTDRYYDKKDITG 84  Caenorhabditis ...

Feature 1                                                               ########                 
4NYH_A        85 TVPYLKIFTVg-----------HQVPDDETIFKFKHAVNGFLkenkdNDKLIGVHSTHGLNRTGYLICRYLIDVEGVRPD 153 human
1YN9_A        77 AGLLYKKIQVp----------gQTLPPESIVQEFIDTVKEFTek--cPGMLVGVHCTHGINRTGYMVCRYLMHTLGIAPQ 144 Autographa cali...
NP_610696     78 HDVLHQKLMIp----------gKQTPSHKLAQRFCAFVTDFLernadNDKLIGVHCTHGVNRTGYLICYFMISVMNMSPE 147 fruit fly
EFO18445     110 VGVKYEKIWCmg---------hHINIQVENIEKFYNVVNDFLskhvhTGELIGVHCTHGLNRTGYMICRYLIEVDGWDVD 180 Loa loa
XP_002736003  85 HKVNVENGARinvqykkiytlgHVVPDYGKIQSFKRTIDQFVeenkcNDTLVGVHCTHGVNRTGYMVCRYLIDSLKWKPD 164 Saccoglossus ko...
XP_001639672  68 EGIIYKKMMCa----------gHVIPKKKDIKRFEDEVKNFLen-dkTGSLVGIHCTHGVNRTGYMVCRYLIDCCGYEPE 136 starlet sea ane...
NP_001036968  78 AGILHKKIIMp----------gRILPPENKVKEFMDAVDDFLgk--dSDILLGVHCTHGLNRTGYMVCRYMRDRLGMSGK 145 domestic silkworm
XP_002126475  81 NGISHHKIFVp----------gQIIPPPKVVSDFTSIMSKFEknkqsDNEVIAVHCTHGLNRTGYLICRYLIEEKKFKPK 150 Ciona intestinalis
NP_495959    104 HGVKYLKLNCpg---------hEVNEREDLVQDFINAVKEFVndkenDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS 174 Caenorhabditis ...
NP_001254988  85 MCVQYEKVNCpg---------rGFIERDDCVESFHQVIQDYTdkcddPDALIGVHCTNGINRCGYLICRFLIDRLGWSSH 155 Caenorhabditis ...

Feature 1                       #         
4NYH_A       154 DAIELFNRCRGHCLERqNYIEDLQN 178 human
1YN9_A       145 EAIDRFEKARGHKIERqNYVQDLLI 169 Autographa californica nucleopolyhedrovirus
NP_610696    148 EAIQTFSLARGHEIERdNYLSSLKT 172 fruit fly
EFO18445     181 SAIEQFEYCRGYKIERkKYIDSLRD 205 Loa loa
XP_002736003 165 RAIEEFNKARGHSIERqNYLDDLKK 189 Saccoglossus kowalevskii
XP_001639672 137 KAIEAFNQARGHPLEReNYLEDLKK 161 starlet sea anemone
NP_001036968 146 EAIKKFERARGYAIERiVYTSDLLK 170 domestic silkworm
XP_002126475 151 DAIEKFNSARGHKIEReNYLKDLIS 175 Ciona intestinalis
NP_495959    175 DAISMFEYYRGHPMEReHYKKSLYE 199 Caenorhabditis elegans
NP_001254988 156 EAIDAFEQARGYSIEKgAYVMALHK 180 Caenorhabditis elegans

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