2VZ5,3DIW,4E3B


Conserved Protein Domain Family
PDZ_TAX1BP3-like
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cd10822: PDZ_TAX1BP3-like 
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PDZ domain of tax1-binding protein 3 (TAX1BP3), and related domains
PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of TAX1BP3, and related domains. TAX1BP3 (also known as glutaminase-interacting protein 3, tax interaction protein 1, TIP-1, tax-interacting protein 1) may regulate a number of protein-protein interactions by competing for PDZ domain binding sites. TAX1BP3 binds beta-catenin and may act as an inhibitor of the Wnt signaling pathway. It competes with LIN7A (also known as Lin-7A or LIN-7A) for inward rectifier potassium channel 4 (KCNJ4) binding, and thereby promotes KCNJ4 internalization. It may play a role in the Rho signaling pathway, and in the activation of CDC42 by the viral protein HPV16 E6. Binding partners of the TAX1BP3 PDZ domain include beta-catenin, KCNJ4, glutaminase liver isoform (GLS2), rho guanine nucleotide exchange factor 16 (ARHGEF16), rhotekin, and CDK5 regulatory subunit-associated protein 3 (also known as LAPZ). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This TAX1BP3-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Links
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Statistics
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PSSM-Id: 467265
Aligned: 17 rows
Threshold Bit Score: 152.492
Created: 22-Apr-2009
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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peptide binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids
  • Structure:4E3B: PDZ domain of human Tax-interacting Protein-1 (TIP1) binds CAL inhibitor peptide iCAL36L (ANSRWPTSIL); contacts at 4A
    - View structure with Cn3D
  • Structure:3DIW: PDZ domain of Mus musculus Tax-interacting Protein-1 (TIP1) binds beta-catenin C-terminal peptide (NQLAWFDTDL); contacts at 4A
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #######                       #  #                            
2VZ5_A        26 RVEIHKLRqg-----enLILGFSIGGGIDQDPsQNPFsedktDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVT 100 human
3DIW_A        15 RVEIHKLRqg-----enLILGFSIGGGIDQDPsQNPFsedktDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVT 89  house mouse
4E3B_A         5 RVEIHKLRqg-----enLILGFSIGGGIDQDPsQNPFsedktDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVT 79  human
NP_612045     20 PITLHKEKdydqegreiLKCGFKIGGGIDQDYkKSPQgy--tDYGIYVTEVHEGSPAARAGLRIHDKILQCNGYDFTMVT 97  fruit fly
EFX74856      18 PITLHKESvldhegrevHRCGFKIGGGIDQDFrKSPQny--sDNGIYVTEVQENSPAAKAGLRMNDKILQCNGYDLTMCT 95  Daphnia pulex
Q9DBG9        15 RVEIHKLRqg-----enLILGFSIGGGIDQDPsQNPFsedktDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVT 89  house mouse
ELU04633      29 GQQVLEEDgk-----prFRCGFRIGGGIDQDPaKSPQgy--pDKGVYITFVYEGGPAFLAGLQVHDKILQVNGHDFTVVT 101 Capitella teleta
XP_013412133  30 GNPVYDQDgk-----qrFRCGFKIGGGIDQDNsKSPQgy--pDKGIYVTFIYENGPAAQCGLEVHDKILQVNGHDMTVVT 102 Lingula anatina
XP_013067828  29 GNPIREPDgk-----qrYRCGFRIGGGIDQDPsQSPQgy--pDKGVYVTYIHDNSPASRCGLQLHDKILQVNGKDFTLVT 101 Biomphalaria gl...
XP_002126764  16 CIEIVKDVqd-----gnLILGFAIGGGIDQDAsKNPFip--nDSGIFVTRVYPGGPADKAGLKVGDKILQVNGYDVTMAT 88  vase tunicate

Feature 1        #   #  ##             
2VZ5_A       101 HDQARKRLTKrseeVVRLLVTR 122 human
3DIW_A        90 HDQARKRLTKrseeVVRLLVTR 111 house mouse
4E3B_A        80 HDQARKRLTKrseeVVRLLVTR 101 human
NP_612045     98 HKKAVSYIRKn--pILNMLVAR 117 fruit fly
EFX74856      96 HKKAVDYIKKy--pVLNMLVAR 115 Daphnia pulex
Q9DBG9        90 HDQARKRLTKrseeVVRLLVTR 111 house mouse
ELU04633     102 HKKAVEYIKRk--pVLNMLIYR 121 Capitella teleta
XP_013412133 103 HKKAVDYIQRk--pVLNMLVFR 122 Lingula anatina
XP_013067828 102 HKQAVESIRKk--pVLKMLVYR 121 Biomphalaria glabrata
XP_002126764  89 QKQAKKRLVKnq-rIVRLKVTR 109 vase tunicate

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