1FHR,1G6G


Conserved Protein Domain Family
FHA
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cd00060: FHA (this model, PSSM-Id:238017 is obsolete and has been replaced by 438714)
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Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
Links
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Statistics
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PSSM-Id: 238017
Aligned: 141 rows
Threshold Bit Score: 34.6694
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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phosphopeptide
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:phosphopeptide binding site
Evidence:
  • Comment:conserved residues are involved in binding directly to the ligand backbone and phosphate group
  • Comment: non-conserved residues may determine binding specificity
  • Structure:1FHR_A; FHA2 binds a phosphotyrosyl peptide
    - View structure with Cn3D
  • Structure:1G6G_A; FHA binds a phosphothreonine peptide
    - View structure with Cn3D
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                    #                     # ##                        
1FHR_A       5 FLTLKPLpds--iiqESLEIQqgvnPFFIGRSEDc--------NCKIE--DNRLSRVHCFIFKKrhavgksmyespaqgl 72   baker's yeast
1170654      7 LVTIKRSgv----dgPHFPLSl--sTCLFGRGIEc--------DIRIQ--LPVVSKQHCKIEIHe--------------q 56   human
2555105    633 QACLVNLtadpilsgTLFYLLpq-gLVRIGRGRLpggssssqpDIVLD--GPLVALQHCSIEHEr--------------g 695  fruit fly
T30249       7 LVTIKRSgd----dgAHFPLSl--sSCLFGRSIEc--------DIRIQ--LPVVSQRHCPIVVQe--------------q 56   house mouse
BAA78329     5 GYIVIIKrtg--segHRYPLSq--rECLFGRGTEc--------DIRLQ--LPVVSKQQCKIEFNeq-------------l 57   long-nosed potoroo
NP_224908    2 AVRLIVDegp--lsgVIFVLEdg-iSWSIGRDSSa-------nDIPIE--DPKLGASQAIINKTd--------------g 55   Chlamydophila pn...
AAD20441   354 LPVLIVMnndghlstHRITLHe--gVTGVGSDSQmsnf--sqhNIYLD--GPDIRGRHAAIAFMe--------------- 412  Caenorhabditis e...
NP_496374    5 GIKIKNSsg-----eEVYVLKekgsVVNFGREKKv-------cHITFDphAARVSRIHASIEWGd--------------- 57   Caenorhabditis e...
NP_220183    2 GIRLVIDkgp--lsgTVLILEng-tSWSLGSDGKa-------sDILLQ--DEKLAPSQIRITLKd--------------g 55   Chlamydia tracho...
NP_296419    2 GIRLVVDkgp--lsgTVLILEng-tSWSLGSDGKa-------sDILLQ--DEKLAPAQVRVTLKd--------------- 54   agent of mouse p...

Feature 1               ## #                                        
1FHR_A      73 DDIWYCHTGTN-VSYLNNNRMIqgTKFLLQdgDEIKIIwdknnkfVIGFKVEI 124  baker's yeast
1170654     57 EAILHNFSSTN-PTQVNGSVID--EPVRLKhgDVITIId-----rSFRYENES 101  human
2555105    696 GKLYVIPGSEDfETYVNGELLKd-RRQLFHg-DRLVIGg------SHYFRISN 740  fruit fly
T30249      57 EAILYNFSSTN-PTQVNGVTID--EPVRLRhgDIITIId-----rSFRYEDGN 101  house mouse
BAA78329    58 EAILINLNSAN-PTQLNGATFY--HPVKLEhgDLITIFd-----rSFRFEYEN 102  long-nosed potoroo
NP_224908   56 SYYITNLDDTI-PIVVNGVAIQ--ETTQLKneDTILLG-------SNQYSFLS 98   Chlamydophila pneumoniae CWL029
AAD20441   413 GVVTLTPSTRDaYLEVNGHQLM--QTEILRdgDHIRIGa------DHSFKFST 457  Caenorhabditis elegans
NP_496374   58 EGLFFTDKSKE-GTEINGTRLKqsSQELHEgvYQLAIG-------GISMTLEV 102  Caenorhabditis elegans
NP_220183   56 EYYLENLDALR-PVSVDGTVIT--APVLLKdgVSFVMG-------SCQVSFFK 98   Chlamydia trachomatis
NP_296419   55 GEYYLENLDVSrPVLVNGVAIT--APTLLKegIPFVMG-------SCEWSFFK 98   agent of mouse pneumonitis

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