Conserved Protein Domain Family
LIC

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TIGR00860: LIC 
Cation transporter family protein
The Ligand-gated Ion Channel (LIC) Family of Neurotransmitter Receptors TC 1.A.9)Members of the LIC family of ionotropic neurotransmitter receptors are found only in vertebrate and invertebrate animals. They exhibit receptor specificity for (1)acetylcholine, (2) serotonin, (3) glycine, (4) glutamate and (5) g-aminobutyric acid (GABA). All of these receptor channels are probably hetero- orhomopentameric. The best characterized are the nicotinic acetyl-choline receptors which are pentameric channels of a2bgd subunit composition. All subunits arehomologous. The three dimensional structures of the protein complex in both the open and closed configurations have been solved at 0.9 nm resolution.The channel protein complexes of the LIC family preferentially transport cations or anions depending on the channel (e.g., the acetylcholine receptors are cationselective while glycine receptors are anion selective). [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
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PSSM-Id: 273305
Aligned: 21 rows
Threshold Bit Score: 488.454
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P26714     1 MWGIiv--pFFSASLMCSLVAVVRCQ----QDTDHFANVT-NTIDSLLKGYDIRLRPS--------FGGAPLEIGIEVIL 65  great pond snail
CAA74622   3 NSVPlatriGPMLALICTVSTIMSAV----EAKRKLKEQE--IIQRILNNYDWRVRPRglnaswpdTGG-PVLVTVNIYL 75  barber pole worm
AAB03404   2 NSFP----------IVCWNLAFLILV----VAKKKLKEQE--IIQRTLKDYDWRVRPRgnnlswpdTGG-PVLVSVNIYL 64  Onchocerca volvulus
P36544     3 CSPG-----GVWLALAASLLHVSLQG-----------EFQrKLYKELVKNYNPLERPVa-------nDSQPLTVYFSLSL 59  human
P54131     3 GS--------LCLALAASILHVSLQG-----------EFQrKLYKDLVKNYNPLERPVa-------nDSLPLTVYFSLSL 56  cattle
AAF35885   3 GRRG-----GIWLALAAALLHVSLQG-----------EFQrRLYKELVKNYNPLERPVa-------nDSQPLTVYFSLSL 59  house mouse
P22770     3 LRAL-----MLWLLAAAGLVRESLQG-----------EFQrKLYKELLKNYNPLERPVa-------nDSQPLTVYFTLSL 59  chicken
P13908     3 LAVI-----GLFTLFTSIIAITPAREf------VSLAEREdALLRELFQGYQRWVRPVq-------hANHSVKVRFGLKI 64  goldfish
P46098     5 VQQA-----LLALLLPTLLAQGEAR-----RSRNTTRPALlRLSDYLLTNYRKGVRPVr-------dWRKPTTVSIDVIV 67  human
AAC06137   5 LQLA-----LLALLLPTSLAQGEVRGkgtaQAHNSTRPALqRLSDHLLADYRKSVRPVr-------dWRKPTTVSIDAIV 72  domestic guinea pig
P26714    66 ASFDSISEVDMDYTITMYLNQYWRDERLQFifnesldlgenRSVT-TMTLTgafaEKIWVPDTFLANDKNSFLHDITEKN 144 great pond snail
CAA74622  76 RSISKIDDVNMEYSAQFTFREEWVDARLAYgrfedestevpPFVVlATSENadqsQQIWMPDTFFQNEKVARRHLIDKPN 155 barber pole worm
AAB03404  65 RSISKIDDVNMEYSAQFTFREEWNDARLGYerladentqvpPFVVlAASEQpdltQQIWMPDTFFQNEKEARRHLIDKPN 144 Onchocerca volvulus
P36544    60 LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWnvs------eyPGVKtVRFPD----GQIWKPDILLYNSADERFDATFHTN 129 human
P54131    57 LQIMDVDEKNQVLTTNIWLQMTWTDHYLQWnas------eyPGVKtVRFPD----GQIWKPDILLYNSADERFDATFHTN 126 cattle
AAF35885  60 LQIMDVDEKNQVLTTNIWLQMSWTDHYLQWnms------eyPGVKnVRFPD----GQIWKPDILLYNSADERFDATFHTN 129 house mouse
P22770    60 MQIMDVDEKNQVLTTNIWLQMYWTDHYLQWnvs------eyPGVKnVRFPD----GLIWKPDILLYNSADERFDATFHTN 129 chicken
P13908    65 SQLVDVDEKNQLMTTNVWLWQEWLDYKLRWnpe------nyGGITsIRVPS----ESIWLPDIVLYENADGRFEGSLMTK 134 goldfish
P46098    68 YAILNVDEKNQVLTTYIWYRQYWTDEFLQWnpe------dfDNITkLSIPT----DSIWVPDILINEFVDVGKSPNIP-Y 136 human
AAC06137  73 YAILSVDEKNQVLTTYIWYRQFWTDEFLQWnpe------dfDNITkLSIPT----DSIWVPDILINEFVDVGKSPNIP-Y 141 domestic guinea pig
P26714   145 KMVRLYGNGSLVYGMRFTTTLACMMDLHNYPLDHQECTVEIESYGYTMDDIVLYWLNDrGAVTGVEDV--SLPQFSITN- 221 great pond snail
CAA74622 156 VLIRIHKDGSILYSVRLSLVLSCPMSLEFYPLDRQNCLIDLASYGYTTQDIKYEWKEQ-NPVQQKDGLrqSLPSFELQD- 233 barber pole worm
AAB03404 145 VLIRIHPDGQILYSVRLSLVLSCPMSLEYYPLDRQTCLIDLASYAYTTDDIKYEWKVK-NPIQQKEGLrqSLPSFELQD- 222 Onchocerca volvulus
P36544   130 VLVNS--SGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGG--WSLDLQMQ----EADISGyiPNGEWDLVGi 201 human
P54131   127 VLVNS--SGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGG--WSLDLQMQ----EADISGyiPNGEWDLVGv 198 cattle
AAF35885 130 VLVNA--SGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGG--WSLDLQMQ----EADISSyiPNGEWDLMGi 201 house mouse
P22770   130 VLVNS--SGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGG--WSLDLQMQ----EADISGyiSNGEWDLVGi 201 chicken
P13908   135 AIVRY--NGMITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVKLVLINQ----QVDRSDffDNGEWEILSa 208 goldfish
P46098   137 VYIRH--QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLpEKVKSDRSVfmNQGEWELLGv 214 human
AAC06137 142 VYVRH--QGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLpEKVKSDKSVfmNQGEWELLGv 219 domestic guinea pig
P26714   222 YATINK-IEELSTGDYQRLSLIFQLQRN--IGYFIFQTYLPSILIVMLSWVSFWINHEATSARVALGITTVLTMTTISNG 298 great pond snail
CAA74622 234 VVTKYC-TSKTNTGEYSCLRTQMVLRRE--FSYYLLQLYIPSFMLVIVSWVSFWLDKDSVPARVTLGVTTLLTMTTQSSG 310 barber pole worm
AAB03404 223 VLTEYC-TSKTNTGEYSCARVLLLLRREyrFSYYLIQLYIPCIMLVVVSWVSFWLDKDAVPARVSLGVTTLLTMTTQASG 301 Onchocerca volvulus
P36544   202 PGKRSErFYECCKEPYPDVTFTVTMRRR--TLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLL 278 human
P54131   199 LGKRSEkFYECCKEPYPDVTFTVSIRRR--TLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLL 275 cattle
AAF35885 202 PGKRNEkFYECCKEPYPDVTYTVTMRRR--TLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLL 278 house mouse
P22770   202 PGKRTEsFYECCKEPYPDITFTVTMRRR--TLYYGLNLLIPCVLISALALLVFLLPAD-SGEKISLGITVLLSLTVFMLL 278 chicken
P13908   209 TGVKGS--RQDSHLSYPYITYSFILKRL--PLFYTLFLIIPCLGLSFLTVLVFYLPSD-EGEKVSLSTSVLVSLTVFLLV 283 goldfish
P46098   215 LPYFREfS-MESSNYYAEMKFYVVIRRR--PLFYVVSLLLPSIFLMVMDIVGFYLPPN-SGERVSFKITLLLGYSVFLII 290 human
AAC06137 220 LTEFLEfSDRESRGSFAEMKFYVVIRRR--PLFYAVTLLLPSIFLMIVDIVGFYLPPD-SGERVSFKITLLLGYSVFLII 296 domestic guinea pig
P26714   299 VRSSLPRIS-YVKAIDIYLVMCFVFVFAALLEYAAVNYTYWGARAKRK------AKRLRERATSVRKRVDDGdQMNNTNM 371 great pond snail
CAA74622 311 INANVPPVS-YTKAIDVWIGVCLAFIFGALLEFAWVNYAARK-----D------MSCG-----QRMMKQLPQdGYR-PLA 372 barber pole worm
AAB03404 302 INAKLPPVS-YIKAVDVWIGVCLAFIFGALLEYALVNYHGR------------------------------Qe------- 343 Onchocerca volvulus
P36544   279 VAEIMPATSdSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKmpk-wtRVILLNWCAWFLRMKRPGeDKVRPAC 357 human
P54131   276 VAEIMPATSdSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKmpk-wtRVVLLNWCAWFLRMKRPGeDKVRPAC 354 cattle
AAF35885 279 VAEIMPATSdSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKmpk-wtRIILLNWCAWFLRMKRPGeDKVRPAC 357 house mouse
P22770   279 VAEIMPATSdSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKmpk-wtRVILLNWCAWFLRMKRPGeDKVRPAC 357 chicken
P13908   284 IEEIIPSSSkVIPLIGEYLLFIMIFVTLSIIVTIFVINVHHRSSATYHpmspwvRSLFLQRLPHLLCMRGNTdRYHYPEL 363 goldfish
P46098   291 VSDTLPATAiGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPvpa-wlRHLVLERIAWLLCLREQStSQRPPAT 369 human
AAC06137 297 VSDTLPATAiGTPLISVYFVVCMALLVISLAETILIVRLVHKQDLQQPvpl-wlRHLVLERIAGLLCLGEQLtSHRGPAT 375 domestic guinea pig
P26714   372 DTVE----LKEVHMVPTSVGvtns----qsfnLDLD-------------------DGSGDDTGFRVVPPIPRsfthshat 424 great pond snail
CAA74622 373 GSQP----RTSFCCR----------------------------------------------------------------- 383 barber pole worm
AAB03404     --------------------------------------------------------------------------------     Onchocerca volvulus
P36544   358 QHKQrrcsLASVEMSAVAPPpasngnllyigfRGLDgvhcvptpdsgvvcgrmacSPTHDEHLLHGGQPPEG-------- 429 human
P54131   355 QHNErrcsLASVEMSAVAGPpatngnllyigfRGLDtmhcaptpdsgvvcgrvacSPTHDEHLLHAGQPSEG-------- 426 cattle
AAF35885 358 QHKPrrcsLASVELSAGAGPpssngnllyigfRGLEgmhcaptpdsgvvcgrlacSPTHDEHLMHGTHPSDG-------- 429 house mouse
P22770   358 QHKQrrcsLSSMEMNTVSGQqcsngnmlyigfRGLDgvhctpttdsgvicgrmtcSPTEEENLLHSGHPSEG-------- 429 chicken
P13908   364 EPHS-----PDLKPRNKKGPp------------GPEg---------------------EGQALIN--------------- 390 goldfish
P46098   370 SQATktddCSAMGNHCSHMGg----------pQDFEk--------------------SPRDRCSPPPPPREA-------- 411 human
AAC06137 376 LQATktddFSAMGNHCGPLGg----------pQDLEk--------------------TSRGRGSPPPPPREA-------- 417 domestic guinea pig
P26714   425 thgyiptnvvrRRSSSHVPPRRRrllshFRQKAKSIKVKIPRVQDVNTIDKYARLMFPLLFIIFNTSYWSVY 496 great pond snail
CAA74622 384 ------------------------------------IFVRRHKERSKRIDVVSRLVFPIGYACFNVLYWAVY 419 barber pole worm
AAB03404 344 -------------------------------------FLKKEKKK--------------------------- 351 Onchocerca volvulus
P36544   430 -----------DPDLAKILEEVRyianrFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490 human
P54131   427 -----------DPDLAKILEEVRyiahrFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTILCTIGILMSA 487 cattle
AAF35885 430 -----------DPDLAKILEEVRyianrFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSA 490 house mouse
P22770   430 -----------DPDLAKILEEVRyianrFRDQDEEEAICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSA 490 chicken
P13908   391 -------------LLEQATNSVRyisrhIKKEHFIREVVQDWKFVAQVLDRIFLWTFLTVSVLGTILIFTPA 449 goldfish
P46098   412 -----------SLAVCGLLQELSsirqfLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLW 472 human
AAC06137 418 -----------SLAMCGLLQELAsirhfLEKREETREVARDWLRVGSVLDKLLFRVYLLAVLAYSITLVTLW 478 domestic guinea pig
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