Conserved Protein Domain Family
Ciart
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pfam15673: Ciart (this model, PSSM-Id:374006 is obsolete and has been replaced by 464794)
Circadian-associated transcriptional repressor
Circadian-associated transcriptional repressor (Ciart or Chrono) is a negative regulatory component of the circadian clock. It functions as a transcriptional repressor, modulating BMAL1-CLOCK activity. It also regulates metabolic pathways such as the glucocorticoid response triggered by behavioral stress.
Links
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Statistics
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PSSM-Id: 374006
Aligned: 5 rows
Threshold Bit Score: 515.625
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_007485432 251 SGMKRSRDNEEETCHNIQNPRTEGDRLFAQKCKELQGFIRPLTDLLNGLKMGRYERGLSSFQQSVAMDRIQRIVGVLQKP 330 gray short-tail...
XP_003800456  89 SGVKRSRDGELETSQNIQGCTTEGDLLFAQKCKELQGYITPLTDLLNRLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 168 small-eared galago
Q3TQ03        85 SEVKRSRDGEQETSLNTQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGVLQKP 164 house mouse
XP_012405149 102 SGMKRSRDSEEETCLNVQNPLTEGDRLFAQKCKELQGFIRPLTDLLNGLKMGRYERGLSSFQQSVAMDRIQRIVGVLQKP 181 Tasmanian devil
XP_010587958 159 SRVKRSRDGELESSLNIQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKP 238 African savanna...

XP_007485432 331 EMGERYLGTLLQVEGMLKTWFPHVASQRATPGDGKHRlLSKRLASSQANPTGPSADLARKNLNQIQLRHLdqgkeklhSQ 410 gray short-tail...
XP_003800456 169 YMGERYLGTLLQVEGMLKTWFPHIAAQKSLLGHSRHQ-LTKHFPSHHSDSAASFPVSSLEKVDQSQLGHV--------VL 239 small-eared galago
Q3TQ03       165 QMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQ-ISKHFPSHHGDPGAASPAPLLEKMGQTQLGHL--------VL 235 house mouse
XP_012405149 182 EMGERYLGTLLQVEGMLKTWFPHVTSQKSPPEDGKHKiLSKRLASSQTHPTGPSADLPRREINQIQPRHLdqgkeklhsq 261 Tasmanian devil
XP_010587958 239 QMGERYLGTLLQVEGMLKTWFPHIAAQRSLLGDNRHQ-LTKPLPSHHTNLAVSSPAPPMAKMNQTQLGHL--------VL 309 African savanna...

XP_007485432 411 EQELPQLLPEWPAMNLTWIHTTPICNPPLSSLGSAAFSHGLLGPGASFGFILFLQHGAQSFARSAPTTPVPYSAVSSVVC 490 gray short-tail...
XP_003800456 240 KPEQPCHLTDWPALNLTWIHTTPICNPPLSSPGTISFSHGPLGTGTSIGVIFFLQHGVQPFTHSTPTTPVLPTTASPVIS 319 small-eared galago
Q3TQ03       236 KPKQPWHLTGWPAMNLTWIHSTPICNPPLSSQGSAS-GHSPIGTGASIGVILVLQKGGQPFTHSAPGTPVPPTPLSPVVP 314 house mouse
XP_012405149 262 eqesaqllpEWPAMNLTWIHTSPICNPPLSSLGSAAFSHGLLGPGTSFGVILFLQPGTQSLAYSAPTTPIPAATVSPVVC 341 Tasmanian devil
XP_010587958 310 KQKQPWHLTEWPAMDLTWIHTTPICNPPLSSPGTISLSHGPLGTATSIGVILFLQHGVQPFTHSAPATPVPPPTTSPVTP 389 African savanna...

XP_007485432 491 DGPKNISEEEPRCYSLPVSLSstpltSERSHSLSSPCLPTVTREKTPRMDEK 542 gray short-tailed opossum
XP_003800456 320 GDPKKLSREGPRCYSLPVTLP-----SDRSCPLSPPSLPIMAREMTVGHLEQ 366 small-eared galago
Q3TQ03       315 GDLKKLPGEEPRCHSLPVTLP-----SDWSCILCPPVLPTTDREMTKGHPEp 361 house mouse
XP_012405149 342 DGPKDLPEEGPRCYSLPASLAstsltSEWSPTLSPPCLPMVAKEVITRMDEK 393 Tasmanian devil
XP_010587958 390 GDTKKLSGEGPHCHSxTVTLP-----SDWNCTLCSPGLPTVTREMTMGHLEQ 436 African savanna elephant
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