Conserved Protein Domain Family
FAM101
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pfam15068: FAM101 (this model, PSSM-Id:405714 is obsolete and has been replaced by 464483)
FAM101 family
This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localization and shape in the nucleus plays a role in cellular and developmental processes.
Links
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Statistics
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PSSM-Id: 405714
Aligned: 22 rows
Threshold Bit Score: 231.109
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005988985   1 MVGHLHLQGMDEsLKGkNREGLLDSPDS-GLPPSP--SPPFYSLssGILEGRAGGSTT-PIEPLGHSSRKEAREGKL--- 73  coelacanth
XP_006640307   1 MVGHLHLQAMDEsLKGkTREGLLDSPDS-GLPPSP--SPPFYSLspAILESRAGGSTT-PMEQQGFSYRKESKEGKL--- 73  spotted gar
Q8QHA4         1 MVGHLHLQAMDDsLKGkNREGLLDSPDS-GLPPSP--SPPFYSLspGILESRSASCST-PTELQGYC-RKESREGKL--- 72  zebrafish
XP_003445595   1 MVGHLHLQAMDDsLKGkNREGLLDSPDS-GLPPSP--SPPFCSLspALIESRSGSCTT-PVESHHGYYKKESREGKL--- 73  Nile tilapia
7_pfamImport   1 MVGHLHLQAMDDsLKGkNREGLLDSPDS-GLPPSP--SPINWGLs-V------------PVMAAGGDSRRSRVSAKTdlv 64 
2_pfamImport   1 MVGHLHLQGMEDsLKDkSREGLLDRADSlKAPPYP--SPPVSRM-------RTGGGGAaSGRPIWKSGPADTPNSISvq- 70 
XP_007490002   1 MVGHLHFQGMEDsLKEkSRDGLLDSPDS-GLPPSP--SPPFYSLspGIMDSRAAGSGA-AAEAPGSGPRGYPQEATA--- 73  gray short-tail...
XP_003430674   1 MVGHLHLQGMEEsLKErSREGLLDSPDS-GLPPSP--SPPFYALs-P--DGRAAGGSAiPTDPSAVA----PQEGRE--- 67  platypus
XP_003507862   1 MVGHLHLQAMGDt-REqSRDGLLDSPDS-GLPPSPspSPPFYALspGTLDARA------TTEPPG------PNEAPA--- 63  Chinese hamster
Q6ZTI6         1 MVGHLHLQGMEDsLKEqGREGLLDSPDS-GLPPSPspSPPFYSLapGILDARAGGAGA-SSEPPG------PSEARA--- 69  human

XP_005988985  74 --LPYLLLNSAASDPRPKMHPIFFGESIEVKPEPSQEIRCNSEIKYDSEKHYRDHVYYaPIPTVTAYSETVIAAPNCTWR 151 coelacanth
XP_006640307  74 --LPYLLLNSSGTEMKSRMYPVFFGESIEVCPKPKREVRCNSEVKYDSDKHYRDNVYCaPVPTVTSYSETVIAAPNCTWR 151 spotted gar
Q8QHA4        73 --LPYLLLNSQGPDAKSRMYPVFYGESIEVNPKPEKEIKFNSAVKYASDRHFRDQVYCaLVPTPTSFSETIVAVQNCTWR 150 zebrafish
XP_003445595  74 --LPYLLLNSTGTDPKTRMHPVFFGESIEVNPKPEKEIKCNSEVKYDSDKHYRDRVFCtPVPTATSFSETVVAVRNCTWR 151 Nile tilapia
7_pfamImport  65 ltLPYLLLNSTNTDAKTRMYPVFFGESIEVNPKPEQEIKCSSEVRYDSDKHYQDRVYCaPVPTATSFSETVVAVRNCTWR 144
2_pfamImport  71 keIPYLLLNNSPQETRPRMHPVVFGESIEVNPEPVQEIRCNSEIKYDSEKHYRDHVFYvPTPTVTSYSETIISTPNCTWR 150
XP_007490002  74 --APHLLQDSAVLEMRPRLLPVFFGESIEVNPEPTQEIRCNSEVRYDSEKHYRDDIFYiPVPTVTSYSETIIATPNCTWR 151 gray short-tail...
XP_003430674  68 --VPCAFPCTLVPEMRPRMYPVFFGESIEVNPQPGQEIRWNSEVKYDSEKHYRDDIFYvPVPTVTSFSETIIATPNCTWR 145 platypus
XP_003507862  64 --ATSLFQSPPALEMRPRLLPVFFGESIKVDPEPAHEIRCNSEVTYTSERYFRDKIFYaPVPTVTAYSETIVAAPNCTWR 141 Chinese hamster
Q6ZTI6        70 --PPSQLPNPPASEMRPRMLPVFFGESIKVNPEPTHEIRCNSEVKYASEKHFQDKVFYaPVPTVTAYSETIVAAPNCTWR 147 human

XP_005988985 152 NYKSELIFEPKQKPLRFQTTTIIFPKHAKNIYRTTLSYNS---RNAKRWFMSSVQLEST 207 coelacanth
XP_006640307 152 NYKTELQFEPRQKPLRFQSTTIIFPKHAKNIYRTTLNYNG---SSADRWFVSRVQLESS 207 spotted gar
Q8QHA4       151 SYKSEVHFQPRHRPLHFQSTAIVFPKHTRNTYRTTLNYNSnrnAAGRRWFVSTVRLEST 209 zebrafish
XP_003445595 152 SYKTQVYLEPRQKPVSYQSTTIIYPKHAKNTYRTTLNYNA---TGSRRWYVSTVKLESS 207 Nile tilapia
7_pfamImport 145 SYKSQVYLEPRQKPISYQSTTIIYPKHAKNTYRTTLNYNA---TGSRRWFVSTVQLESN 200
2_pfamImport 151 NYKSQLVFEPRNKPLRFQSTTIIFPKHTKNIYRTTLNYNC---GGSKKWFSSSVQLELC 206
XP_007490002 152 NYKTQLTFEPRQRALRFQSTTIIFPKHPKNTYRTTLHYSL---GCPKRWFASSVQLELC 207 gray short-tailed opossum
XP_003430674 146 NYKTQLHLEPRPRPLRFQTTTIIYPKHAKNTFRTTLRCSL---GCPKRWFASSVRLELw 201 platypus
XP_003507862 142 SYRSQLTLEPRPRALRFGSTAIIFPKLARNSFRTTLQCSL---GQPRHWFSSSLQLQRC 197 Chinese hamster
Q6ZTI6       148 NYRSQLTLEPRPRALRFRSTTIIFPKHARSTFRTTLHCSL---GRPSRWFTASVQLQLC 203 human
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