Conserved Protein Domain Family
PA_hPAP21_like
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cd02127: PA_hPAP21_like 
PA_hPAP21_like: Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation may be required for the secretion of hPAP21. The significance of the PA domain to hPAP21 has not been ascertained. It may be a protein-protein interaction domain. At peptidase active sites, the PA domain may participate in substrate binding and/or promoting conformational changes, which influence the stability and accessibility of the site to substrate.
Links
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Statistics
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PSSM-Id: 239042
Aligned: 7 rows
Threshold Bit Score: 181.033
Created: 18-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PA/protease or
Feature 1:PA/protease or protease-like domain interface [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
Q9BSG0     51 DFGG----IFHTRYEQIHLVPAEPPEACg-eLSNGfFIQDQIALVERGGCSFLSKTRVVQEHGGRAVIISDNavdn---d 122 human
Q9W1W9     57 DFGS----AFSERLEGVPLVITDPPGACq-eIRNArDLNGGVALIDRGECSFLTKTLRAEAAGALAAIITEYnpssp-ef 130 fruit fly
AAH70658   58 DFGG----IFNQRYDQIHLVPADPLEACg-eLNNGaFIQGEIALVERGGCSFLSKTRVIQEHGGLAVIIADNaadn---d 129 African clawed frog
ABF18536   34 DFGTsf-eSTSFGVKEGKLVPAIPSDACepdFVNEkDLKGNIVLVERGECSFLTKAINVEQVGGRAVIITEVdsgsd-dy 111 yellow fever mosquito
XP_973316  74 DFGAp--fNESFYIKHVPLVPIQPKFGCt-pPENIeDIEGNVALIERGECSFKMKAKIAEKAGAQAVIITDVskpt---e 147 red flour beetle
AAW26748   42 QIGP----HFNTTFTSTSLVLTEPLHACe-lVSNAhEVNRNIALIIRGGCSFVTKAINAHVAGAVAAIVYDFnrn----a 112 Schistosoma japonicum
CAE68661   56 MLGThfpdGINKTMKHMDMVLADPINGCd-tLRNI-IFVPTVILMERGGCSFTEKAIHGQKAGASVVMVTDSenieygpq 133 Caenorhabditis bri...

Feature 1        ###                                        
Q9BSG0    123 sfYVEMIQDSTQRTADIPALFLLGRDGYMIRRSLEQhglpWAIISI 168 human
Q9W1W9    131 ehYIEMIHDNSQQDANIPAGFLLGKNGVIIRSTLQRlkrvHALINI 176 fruit fly
AAH70658  130 srYVDMINDNSGRTADIPALFLLGRDGYMIQRSLEQhglpWAIISI 175 African clawed frog
ABF18536  112 dyYIEMIHDKTDRDTNIPAAFLLGKNGLIIRKTLAKlhlrYALINL 157 yellow fever mosquito
XP_973316 148 eyFIEMIDDDSSDEVHIPAAFLMGKNGIMITKTLERlkrsYAIINL 193 red flour beetle
AAW26748  113 iqTFSMIQDDTSRRVQIPCAFMNGKDGDSITTALDSlnltKAIVDF 158 Schistosoma japonicum
CAE68661  134 qyYVNMIPDESLDRADIPCVFVASITGRYFRDHLEEggsiTLDLPV 179 Caenorhabditis briggsae

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