Conserved Protein Domain Family
mRING-H2-C3DHC3_ZFPL1
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cd16487: mRING-H2-C3DHC3_ZFPL1 (this model, PSSM-Id:319401 is obsolete and has been replaced by 438150)
Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins
ZFPL1, also known as zinc finger protein MCG4, is a novel mitotic Golgi phosphoprotein required for cis-Golgi integrity and efficient endoplasmic reticulum (ER)-to-Golgi transport via directly interacting with the cis-Golgi matrix protein GM130. ZFPL1 is a widely expressed integral membrane protein with two predicted zinc fingers at its N-terminus. One is a novel type of zinc finger, and the other is a modified RING-H2 finger that lacks the fourth zinc-binding residue of the consensus C3H2C3-type RING-H2 finger. It also contains a bipartite nuclear localization signal (NLS), and a leucine zipper at the C-terminus.
Links
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Statistics
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PSSM-Id: 319401
Aligned: 20 rows
Threshold Bit Score: 91.9621
Created: 19-Oct-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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modified
Feature 1: modified RING-H2 finger (C3DHC3-type) [structural motif], 8 residue positions
Conserved feature residue pattern:C C C D H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:consensus of the canonical C3H2C3-type RING-H2 finger: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, X is any amino acid and the number of X residues varies in different fingers.
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique cross-brace arrangement.
  • Comment:The RING fingers found in ZFPL1 and some homologs are modified RING-H2 fingers that lack the fourth zinc-binding residue of the consensus C3H2C3-type RING-H2 finger.
  • Comment:putative Zn2+ binding sites
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                # #  #  #                  #   #    
O95159        50 NPNCRLCNIPLasr---etTRLVCYDLFHWACLNERAaqlPRNTAPAGYQCPS-CNGPI 104 human
XP_013398398  85 NPVCTLCQRSLadedagncVRLLCYDVFHWSCLNAYAqqlPANTAPAGYQCPA-CKTGI 142 Lingula anatina
CAM91776      13 DPMCQLCKTDLssedsgdcVRLVCYDVFHWKCLDKYArgfPANTAPAGYTCPS-CKSCI 70  Dumeril's clam worm
KPM07232      51 DSKCQICSMNFnme--sgcVRLCCYHLFHLNCLNSYAnrmPANTAPAGYTCPI-CSKPI 106 Sarcoptes scabiei
EFX86665      50 SSLCTLCSTDLsqd---dcIRLICYHVFHLKCLDAYCrqyPVNTAPAGYVCPSpCSHPI 105 common water flea
XP_002604484  50 NPQCSLCGGALadg---dvVRLICYDVFHWSCLNSYAqklPANTAPAGYTCPK-CNSGI 104 Florida lancelet
XP_785452     50 NTKCSLCKNELaeg---dvVRLLCYDVFHWECVDAYArnfPPNTAPAGYTCPS-CNTSI 104 purple sea urchin
NP_001071883  50 IPNCQLCDGSLleg---evVRLLCYDVFHISCLEKHFrnlPLNTAPAGYRCPA-CETKI 104 vase tunicate
XP_004349423  48 SADCVLCNQSLeng---gvVRLTCYDVLHWECLDKYAkslPAHTAPAGYTCPQ-CQAPI 102 Capsaspora owczarzaki ATCC 30864
NP_732721     50 ISNCTLCGTTLeqg---dcVRLVCYHVFHWDCLNARQaalPANTAPRGHQCPA-CSVEI 104 fruit fly

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