Conserved Protein Domain Family
EMP24_GP25L

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pfam01105: EMP24_GP25L (this model, PSSM-Id:395878 is obsolete and has been replaced by 426051)
emp24/gp25L/p24 family/GOLD
Members of this family are implicated in bringing cargo forward from the ER and binding to coat proteins by their cytoplasmic domains. This domain corresponds closely to the beta-strand rich GOLD domain described in. The GOLD domain is always found combined with lipid- or membrane-association domains.
Statistics
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PSSM-Id: 395878
Aligned: 210 rows
Threshold Bit Score: 39.9772
Created: 22-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAM43991      40 ALTFHFVDSKPLCF--SETIenVKESQITGVYDWKasatsPASq-----------------------------VQLRLSV 88  Leishmania braz...
XP_001645974  18 GLHFYIFPGDTKCF--YENL--NKHEQVTGDFIPIsitdvQEPisrei--------------------lkkleFNLNLTI 73  Vanderwaltozyma...
Q1EQ41        21 EIYFKIIGKTPKCFsiDEPV----GTLVHAHYKITtlnagKYGkvh-------------------------enIDLHYAL 71  Entamoeba histo...
EDO07065      20 GFFFNIEYNDRRCF--YENV--PQMAMISVNYEML-----NQEa-----------------------------RACVVRI 61  Babesia bovis
Q4N8G5        19 SLYFLVPQNGERCF--FENV--PEKALLSVSYDLI-----SEEg-----------------------------KDCVLSI 60  Theileria parva
EDL43960      26 AAYFYVKEGVDKCF--VESV--ASNVVITSSYDNF-----GLKgkdafahnastriealrlkkkylpffliaeLKCHINI 96  malaria parasit...
EAZ51577      17 AIYFYVQEGTEKCF--IQEV--PKSVPIHVKYENV-----NNLg-----------------------------IDCTVIF 58  Cryptosporidium...
Q8IDZ5        22 EIYIKMKGKKLKCI--KERI--NKDTLVISKFKTN-----HKN------------------------------ALVSLYI 62  Plasmodium falc...
XP_001614120  25 EVYVTVRPNKIKCL--KERI--NKDTLVVGKFKTD-----SKN------------------------------SPISIFI 65  malaria parasit...
Q4UE31        31 DATTYLEPYQQFCL--SEVV--GKDMFVHLTFGIL-----DLKp----------------------------dQFYSAYV 73  Theileria annulata
CAM43991      89 K-----DSTGN-----VYYDKAMMEGEhs-----------fAVQLNPnVLNG-EQLICFTASSNFVASekdpVKVRIELD 146 Leishmania braz...
XP_001645974  74 He---pFSNNE-----LVYNNFEVAVT--------------NFTFTA-LSNG-EHKICVTPTITDYN-----KLITLEVD 124 Vanderwaltozyma...
Q1EQ41        72 H-----FPQE------LHREDEDAQIDed-----------gVVMFTT-KEVG-EYQICFYVSNAPRYD----IEYKFTLN 123 Entamoeba histo...
EDO07065      62 S-----DEEKK-----VLQNTNLKEATtr-----------gRVTYVA-KNEG-TYYICIDCPGQLWYTaq-mAKIALSIE 117 Babesia bovis
Q4N8G5        61 S-----DNERR-----VLKNMKLDQDQahsmlyscllhcleRLSFVS-PSTG-NYNICVHCPGRLWYMsq-mCKISLNFE 127 Theileria parva
EDL43960      97 Kd---qQG--------RVVYSHDTSAIsk-----------gKVSYLT-KKNG-LYYICISCPSSNWFKst-aIKWSLSIE 151 malaria parasit...
EAZ51577      59 Kn---tE--NI-----EVFSRHVNENDhk-----------gSVAYLP-EVDG-DHKVCIRCDSSNWFKse-qMKWILSID 114 Cryptosporidium...
Q8IDZ5        63 YdvdvnEKNFHtqpklPIFETVNKHDI--------------KTAFTT-FYSS-SYSFCAYNNSDKL------IEVYFEIK 120 Plasmodium falc...
XP_001614120  66 YdadvnERTFNfqkklPIFETINEHDI--------------KTAFTT-FYST-SYSFCAYNSTNKI------LDVFFEIK 123 malaria parasit...
Q4UE31        74 Ie----EGSDQ-----YIFRESAIRNDv-------------SLSFTS--VEGpSITLCVNGPQSG-------TNFNFSLK 122 Theileria annulata
CAM43991     147 QalkNefKARKEliktiqkrrqvdgldvytyqevggelkDILqpRAYLETIERELNAMEELLDQLVMGLTTSVTREFRMR 226 Leishmania braz...
XP_001645974 125 L---S--RTKNNll------------------------nSQR--FDTVDGIHYRINNLVKRLLEIKKEQKLDMLEETTRI 173 Vanderwaltozyma...
Q1EQ41       124 L---EigIEAIDye------------------------nLAK--TEQLNSIEIQFTQQIDLVKALQDEIKFQQEKHDEFE 174 Entamoeba histo...
EDO07065     118 I------ADGNDiygrntq-------------ydvdretTAK--KDEMKNLSEEMRKFSINIINIKNHQRLENNTAKELH 176 Babesia bovis
Q4N8G5       128 I---AdvSSGGDssqyd-----------------vnyetTAK--KQQVESLTSHLHHFIASANVIQEYQISENRNSTKLY 185 Theileria parva
EDL43960     152 V---G--GSDVDie------------------------nVAK--KSELSETLSILLNLKKKFTSMKLQQIYQKQMATNLY 200 malaria parasit...
EAZ51577     115 T---GniSEHLDvd------------------------sIAS--KDEANYVEEFINSLISKVNNQVSEGEYEFEKQEMFL 165 Cryptosporidium...
Q8IDZ5       121 Y---G--TEARDya------------------------qVAK--TEHLNQGTLYLKQILDQMNIFHVNLKRIRSDEDKEK 169 Plasmodium falc...
XP_001614120 124 H---G--TEARDya------------------------qIAK--SEHLNEATMYLNQILDQMNNFHLNLKRIKASEENEK 172 malaria parasit...
Q4UE31       123 F---G--ADARDys------------------------iIAK--SSHLDPVDIRVQNVLDELSAFHKAQIIGASSIDRIS 171 Theileria annulata
CAM43991     227 ETSESTFTRVWVCALLLIGIISGVLWMQFRFLKSTLR 263 Leishmania braziliensis MHOM/BR/75/M2904
XP_001645974 174 SNSESTRRKIVLFSTIQLLVIIIFFSIQLKRLKLMTI 210 Vanderwaltozyma polyspora DSM 70294
Q1EQ41       175 AVTASTIFRVKLFAFIQIIIFALLAWWQYKNLKSFFR 211 Entamoeba histolytica
EDO07065     177 DTYKSMYNYLLYFYLLQLFIIAATALFSVYHITRFFK 213 Babesia bovis
Q4N8G5       186 DHYKSMNNWILVFYLLEILVVVLTSAFSVYHITRFFK 222 Theileria parva
EDL43960     201 EHNKSVHNKMFYCYILEIIILVAITVYSIVHLKNYFR 237 malaria parasite P. vivax
EAZ51577     166 KQALSVNKRIVIYSIIQLTLVSVISYFSIIHMRNFLR 202 Cryptosporidium parvum Iowa II
Q8IDZ5       170 KAHDKLNDTLMWFSFLNIIIIVIAAIVQDFYFKKFFT 206 Plasmodium falciparum 3D7
XP_001614120 173 KSSDKLNDTLMWFSLMNILIIIVAAIIQDFYFKRFFT 209 malaria parasite P. vivax
Q4UE31       172 EKAIKTYHLLARFAIANSVFVIFSTLCYIFYFRNFFK 208 Theileria annulata
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