EDO38227 302 QKYQKVYNFLKRTLAQDKYEGIRVIEPCVIVADGFNKKFQFAVLGAEMLYIIDNPPKVakgIRMTVDLATITAVKMIHDI 381 starlet sea an... XP_002108932 3 PKNHRVDAFLKRNLPPNEYETLRSFEPCVIVSDREKHVFRYIVLSNDNLYLTENPPRN---VQLLTKLGDIFSMEMIYDL 79 Trichoplax adh... XP_002594428 9 GGNAKLDAFLRRSFDPRQYDRVLATHKCIV-----EKNFSFVILTDDCVYLTENPPRV---IQPAVQLKDIVSIRLINDF 80 Florida lancelet NP_796309 12 RTNSRLDAFLRRHLPPEVYDAVRAYEPCIVVSDAEKHTFKYVVLSDRLIYLTENPPKS---IRRVVALRDVVAIDLIDDY 88 house mouse XP_002687699 12 RKNSRLDAFLRRHLPPEVYDAVRAYEQCIVVSDSEKHTLKYVVLTDRLIYLTENPPKS---IRRVVALRDIVAIDLIDDY 88 cattle 6_pfamImport 2 RRNVELDSFLKRNTERAVYERIRAHEPCVVITETIHEVFSPVVVSDERVYLAEYSPRT---LTEAFGFRRVRDIELVNDL 78 XP_004083337 14 RRNPRLDSFLKRNTDRELYERIRASEPCVVVSDSIHRVYMHVVLSDERVYLTEFSPRT---LITAASLRCVRSIQLVNDF 90 Japanese medaka XP_031586180 91 RRNARLDSFLQRKLERRVYERIRAYEPCVVLSESINKVYMHVVLNDECVYLTEYPPRT---LTAAVSFRRVRYIELVNDL 167 Oreochromis au... CAG04183 10 ardAQLDWFLRRTAEASLHERIRFHEPCVVVSETVDKAYMHVLLSDERVFLTEHAPRT---LTVAVSFGRVRDIELVNDL 86 spotted green ... XP_011611599 12 RGNIKLDSFLRRNTDQAVYERIRSYEPCVVVSETINKAYMHVVLSDELVFLTEYAPRT---LTAALSFRRVRDIKLVNDL 88 torafugu XP_002661405 9 QNNSKLDSFLKRNTSRDVYERIRVSEPCVVVSGSVKKVFMHVILSDECVYLSEYHPRA---LREALSFRHITSIELINDL 85 zebrafish XP_023374177 12 RTNGRLDTFLRRHLPPEVYDAVRAYEPCIVVSDSENHTFKYVVLSDRLVYLTENPPKS---IQRVVALRDVVAIDLIDDY 88 small-eared ga...
EDO38227 382 AEFLGGDLKNRVQHIHVTFKKRpvipqpigdyspNTALKSSLLTAsa-----------------------------lfQR 432 starlet sea an... XP_002108932 80 PSFLSGEDREKCQHIRIQYFID------------DGMLYSQTLSNl--------------------------------PM 115 Trichoplax adh... XP_002594428 81 PDFLGGDQQAETQHICIRHGVQpstps--lppspSTPLRSPHQLSvpdp-------------------------felsEN 133 Florida lancelet NP_796309 89 PEFLSSPDREINQHIRIVYS--------------STVLKKERGKSkgvg-------------------------kflfPA 129 house mouse XP_002687699 89 PEFLSPPDRETNQHIRIIYY--------------STILKKECEKSkgvr-------------------------kflfPF 129 cattle 6_pfamImport 79 PDFLRGRSRDLCQHIRVTYLTD------------KPAVRGRDWLRrdrgvrsplfvmaavaeeeeqekhscnlmqvwrKV 146 XP_004083337 91 PDFLSGKDRERCQHICITYIAE------------KPEGRRPdge-------------------------------glpSA 127 Japanese medaka XP_031586180 168 PDFLTGKHQKRCQHIRIVYVTE------------KPAAKQRNWLKrdkk-------------------------eglpPA 210 Oreochromis au... CAG04183 87 PGFLRGKHRQLCQHTRITYVTQ------------EPVPRRAAWASkgqr------------------------------- 123 spotted green ... XP_011611599 89 PDFLRGKHRELCQHIRITYVTE------------EPVRRRALWLSkgqr-------------------------splpPA 131 torafugu XP_002661405 86 PDFLSGQDRERSLHIRVVYTTK------------NAGEKSErtkg-----------------------------sskmTE 124 zebrafish XP_023374177 89 PEFLSSPVREINQHIRIICS--------------SAVLKKDCGKSkgar-------------------------rllfPF 129 small-eared ga...
EDO38227 433 DDNNRSSTfSRRGSSGApdqhstqLIPSNHLAV------------QASQLKLSaseGNIRQMLEEERLQ----------- 489 starlet sea an... XP_002108932 116 KLSKGMNQaNTRMSNSMp------NSTINEPSLsdgnesrnkfggSTNQLSHSl--LEQRKLPERPKLQ----------- 176 Trichoplax adh... XP_002594428 134 SPSSKNEKkARRTSSk-------lSVSFNEASLqaakresergvpKKAKLSHSlptSQLRNLTLEKEEI----------- 195 Florida lancelet NP_796309 130 HHSTAN-KkVKQENNGPtfwrrkvSRTLNESSLrsqqe--sstpfKDPT-SHP---SDLKELSPAGQ------------- 189 house mouse XP_002687699 130 HHANANNKkVKEENNGPifwrgkkSNSLNESIFryhqe--sstasKDSILGPP---SDLKKLSLHGQ------------- 191 cattle 6_pfamImport 147 SPR------SARRSS---------VPLTRHRDPnstrgktrpgvcSLSLRP---------------PGE----------- 185 XP_004083337 128 APP------SRRSSY---------CPTPTSTGY------------------------------PAEREE----------- 151 Japanese medaka XP_031586180 211 APP------SRRNSH---------CPEITStl-------------------------qeFSTESSQWRK----------- 239 Oreochromis au... CAG04183 124 -----srpaEARTSAVT----------L-----------------------FLs----------SSETK----------- 144 spotted green ... XP_011611599 132 EPP------SRRTSR---------CPPTTRTFE-----------------------GD-RTQRNYNEIE----------- 161 torafugu XP_002661405 125 SPS------RAYNSA------------------------------------------------ARHSLEgvnalllsase 150 zebrafish XP_023374177 130 HYAKAKRK-VKEENNGPalwtgkePRNLKESSLryhpe--sgtpsKDSAVPRP---SDLKELSPPGQ------------- 190 small-eared ga...
EDO38227 490 -----------------------LPSEGPFSRgllPVCGRPLPvppsnrketpsrrrqkkn-------------rrnqeq 533 starlet sea an... XP_002108932 177 -----------------------SRDDYAIKS---STATACVP------------------------------------- 193 Trichoplax adh... XP_002594428 196 -----------------------EQKQQRVGSa--GRESRPLPnpppspnstknsnnskrplpl--------plgldkgd 242 Florida lancelet NP_796309 190 ------------------------------------GTSRPLPtlsscqsmaatdmpvcslslasst--nepqelpdprd 231 house mouse XP_002687699 192 ------------------------RARGPLPN---PSRSCQLTsasrkasgpfcitdtkepq-----------glsdhkd 233 cattle 6_pfamImport 186 -----------------------LPP---LPPs--RSASCPDPeslglagvphppdrppstapsp------tgsptspls 231 XP_004083337 152 -----------------------RPPV--LKSt--RSASCPNPealglvraprppstpps---------------fysts 189 Japanese medaka XP_031586180 240 -----------------------EELPPVLKHt--RSASCPNPetlglirvpqpppfhspsv-----------spassps 283 Oreochromis au... CAG04183 145 -----------------------IRVLASAHSetlSVGGAPQPpshpppasppththa-------------------slp 182 spotted green ... XP_011611599 162 -----------------------IRLLASAHSk--TLSLIRVPqppsllplqlsspadsh---------------tspls 201 torafugu XP_002661405 151 ssswrispsslsdgaleeeeeeeEESV--IPKr--RSASCPNPvvphlfnsspaspl---------------------pn 205 zebrafish XP_023374177 191 ------------------------------------GATRPLPtpsrrschsipatgqavrepscptntkepqglpdhkd 234 small-eared ga...
EDO38227 534 esdtfdsssssnDLELSFRSISPQMDLhplepyerfrvpspdprswrtrkhhrTSSNESSEGvadrefsantghdssggn 613 starlet sea an... XP_002108932 194 ------------RSTVRKKTVQNKNLAp------------------------nFTDAEEKIStndlqnfy----nlidrn 233 Trichoplax adh... XP_002594428 243 hrqssslrapgrRGSSEAASASKTGSLrslgs----------------dssdgSEDWDSWDG------------------ 288 Florida lancelet NP_796309 232 apregsfrldgnQSEFGLGNSLPASPLh------------------------sCRNLEKEES------------------ 269 house mouse XP_002687699 234 slseipfkcngnGNEFYLGNSTLASPLqs------------------------npNLERKES------------------ 271 cattle 6_pfamImport 232 pdsrglhfpdtgQ---------SRLLRrd-----------------------saSGGQEREA------------------ 261 XP_004083337 190 pskdgrktpessQVTRRFGSVLSRLLRre-----------------------nvNEAEEKEA------------------ 228 Japanese medaka XP_031586180 284 lsekslkslesgQLQRRIGSVLSRLLRrg-----------------------cvDSEEEREA------------------ 322 Oreochromis au... CAG04183 183 sptqrlnpthgdQVSGGVGSLLSRLLGre-----------------------rvCGREERAA------------------ 221 spotted green ... XP_011611599 202 ppnprsslpqrdQVPRRIRSVLSRLLKrd-----------------------yvCSGEEREA------------------ 240 torafugu XP_002661405 206 isntehrwrkspEAFSHRGSVLSRAIRrat--------------------ttdKQKGEEKEE------------------ 247 zebrafish XP_023374177 235 slseipfkcsgsRNEFYLGNPLRPPPLq------------------------sDSNPERKES------------------ 272 small-eared ga...
EDO38227 614 idEMDIYILEKQSPMFPFLKSSWNNCILKST-------LQSGKEISSSSSAKrfs--iiD-NSELLTLFNQLKTEILQ-S 682 starlet sea an... XP_002108932 234 qtVVDIYILSDTSKMPMYMHSTWENYMMRQTlem--daNYLRKLGTNKSSKH-------L-TEQQLQLFNQLKEEILT-S 302 Trichoplax adh... XP_002594428 289 --ELHLYMLSAESPMLMQLRSAWNAHLIHATnnltedsPQSTSTAAGTGS------------KQLELLFQQLKRELLGdD 354 Florida lancelet NP_796309 270 --ELHLYIISATSSIFLHLKSSWNNYIIRATllq--dpLCASEHNDVIGKPKp-----yR-SEEKIKHFCQLKSELFLkD 339 house mouse XP_002687699 272 --ELHLYVISTTSSIFLHLKSSWNNYIIKATllq--dpLYVSELSPATGSQKp-----yR-SEEKIKHFGQLKSELFLkD 341 cattle 6_pfamImport 262 --ELHFYAVSNASRLYLHLQSSWNSFIMRSTlsl--dpLHKR---ASSDSCPktr-lpaA-RERTAHLFGQLSCELLQeG 332 XP_004083337 229 --ELHLYAVSLTSRIYFHLQSIWSSFLIRSTlm---ldLRERRCAGSPDPLApp----lS-WERTAHLFGQLRSELLRdD 298 Japanese medaka XP_031586180 323 --ELHLYAVSETSRLYLHLQSLWNSFSIRSTlll--dpLYRRRNCASLSApa------iS-WERTAHLFGQLRSELLQdG 391 Oreochromis au... CAG04183 222 --ELHLYSVSGTSTLYLRLQSLWNSFIIRSTlll--dpLYGGRCRALSDSSPknp-ppvLsREKTAQVFARLSSALLQeG 296 spotted green ... XP_011611599 241 --ELHLYAVSRASRLYLHLQSSWNSFIIRSTlll--dpLYRGRCRALSDSSPgkqlpvvS-RERTAHLLAQLSCELLQeG 315 torafugu XP_002661405 248 --ELHLYAVSPSSRIFLHLQSSWSSYIIRSTlml--dpVYMKKCGLSSSSPKkpinhkiS-WERTCQLFSQLSGELLQeN 322 zebrafish XP_023374177 273 --ELHLYVISTTSSIFLLLKSSWKNYIIKATllq--dpLYASEFSSAAACQKp-----yR-SEEKIKHFSQLKSELFLkD 342 small-eared ga...
EDO38227 683 HHMEKNFVLINELLTAAQKSFSLKKLFWKSPELFNFIVDQIKM-YLPESPSTRSRQRgNNRADEFDyiv------vlLET 755 starlet sea an... XP_002108932 303 TKLEEIYVLLQELNTACIRNYSLKKLFWKTPDLFNYIATSLADvTCSSNREISHWRLpQSRADTLE-----------AQM 371 Trichoplax adh... XP_002594428 355 SGIELVFSLLQELNTAAQRYFTLKKLFWKSGDLFQFLIKQLQK-HLPGTTPVAHGQR-NNRADELElsi------qvAET 426 Florida lancelet NP_796309 340 NTLRKILCLITELRVAAQRNFILKRLFWKTSELFYFLVNKLHE-YLPESRDKHALQNkSQRADELMaci------eiIQT 412 house mouse XP_002687699 342 NTLRKILCLITELKVTAQKNFILKRLFWKTSDLFYFLVNKLHE-YLPESRDKNALHNtSQRADELVvci------eiIQT 414 cattle 6_pfamImport 333 ISVESLYLLLQELRTAAQRDVALRRLFWNSSELLDFLVLTLEE-ALHGRQSPSGVST----ADQLLdidsltlsaliAQT 407 XP_004083337 299 IGVESLYLQLQELRTAAHRSVTLRRLFWKSGEVCDFLVQTLEE-CLHGSQSIRGVLT----ADQLLlga------liVQT 367 Japanese medaka XP_031586180 392 ISVESMYLLLQELRTAAHRSVMLRRLFWRSSEVCTFLLCTLEG-CLHGRQSLGGLYT----ADQLLlss------liVDT 460 Oreochromis au... CAG04183 297 VGVERLHLLLQQLRRAAHRNLALSRLFWKSRDVCVFLVQTLEE-SLHGCRSAGGVHT----ADRLLlss------lvVQT 365 spotted green ... XP_011611599 316 VSVERLYLLLQELRTAAHRSAALCRLFWKSRDIFVFLVQTLEE-SLHGCQSKHGEYT----ADQLLlst------ltVQT 384 torafugu XP_002661405 323 ISLESLYLLLQELRTATYRNPTIKKLFWRspdlypFLVKT------LSESSQGEQGG---VHTADRlllc----tvvVQI 389 zebrafish XP_023374177 343 NTLKKMLHLITELKVAAQKNFILKRLFWKTSDLFSFLVNKLHE-YLPESRDRNALQSqGQRADELVaci------eiIQT 415 small-eared ga...
EDO38227 756 LVCMFRE--TEILQSRLNVLKAHK-------------------GQTLRDLLEHviatpcvgrkssesk----ispaaqll 810 starlet sea an... XP_002108932 372 LLKLINGavTSTSSNSMNSILNLQ-------------------RPHFSRLLEY--------------------------- 405 Trichoplax adh... XP_002594428 427 LCTMFRG--TTVLPSRVIVLNATR-------------------GKHVRNLLEMlvcspggirar------------sprt 473 Florida lancelet NP_796309 413 LGLMFRE--TEIESSRLNTLAAKK-------------------GTLF-NLLVIliskpkvpksc-----------sksda 459 house mouse XP_002687699 415 LGRMFRE--TETESLRLNILAAKK-------------------GTLF-NLLVIlisepqipksg-----------pvfdi 461 cattle 6_pfamImport 408 LAVMFRE--TEVEPARLNLLSAKKaagcsrcsssplsssspprGALASRMLRAlmcdaedq------------------- 466 XP_004083337 368 LAIMFRE--TEVEEARVNVLSVGK-------------------GALTSRMLLAlicdpqtkn------------------ 408 Japanese medaka XP_031586180 461 LAIMFRE--TEVEAARLSLLSAKK-------------------GALASRMLLAlicdpqpqthsggslmdsevscsllts 519 Oreochromis au... CAG04183 366 LATLCRE--ADGDPARLDLLSAEN-------------------AALASRLLLVlcdpatq-------------------- 404 spotted green ... XP_011611599 385 LAIMFRG--TEGEPARHDLLSAEK-------------------GALASRLLLVlicdpeiqnqerd--------cevsyl 435 torafugu XP_002661405 390 LSLMFRE--TEIEPKRLSMLTAKK-------------------GDTTANMLLAlvcdpdlqlp----------------- 431 zebrafish XP_023374177 416 LGLMFRE--TESESSRLNTLAAKK-------------------GTLF-NLLAIlisepqipksy-----------pvfdm 462 small-eared ga...
EDO38227 811 lygpngDVRQAAEEDETAKLLNEVLDCVTSVIYEILTAVHQSSVFKIEN---------------NTINISWLIKIIDTHR 875 starlet sea an... XP_002108932 406 ------EKWHSAEDNENMILEKNITDAAAAVIFEIVLVTQQMLVCCNVKfskyfsqmkywgdviPLMNIWWLINFLESKQ 479 Trichoplax adh... XP_002594428 474 qalrtsLNIQHPEDPEVQSLIRHYSEVATSVLFEIILIAHEAGSGDSDS---------------NVLTLTWVLLVLENMQ 538 Florida lancelet NP_796309 460 qpvadpTSAEVFFDSQLQKLTLEYTDTATALLYEILLIFQQGNLGLGS----------------TKFAISWMMSFLQSCP 523 house mouse XP_002687699 462 qlvadsTLVEMSLDDELQKLILEYTDTATALLYEILLVFQQGNIGLES----------------TKFAISWIMSFLQSCP 525 cattle 6_pfamImport 467 ---------rsptdceRQALLAEYLDAACSLLFELLLLGHDASRCSSAD---------------HFLSIGWILGVLQPHP 522 XP_004083337 409 --------qeppldskLPSLREEYLDAAGSLLFELLLLGHQTSRCLSAG---------------TFLSVGWMLKVLHPHP 465 Japanese medaka XP_031586180 520 svfhvpsmhxtlcflqLQALLAEYLDTAASLLFELLLVGHVTSRCVSAD---------------NFLSVGWILRVLQPHP 584 Oreochromis au... CAG04183 405 -----------tqggdceAWLQEYLDASCSLLFELLLLGHEASRCSPAD---------------SLLSVGWILRVLQPHP 458 spotted green ... XP_011611599 436 lfisvvFLTPFLIFFLLQALLQEYLDASCSLLFELLLLGQEASTYSFAD---------------NFLSVGWILRVVQPHP 500 torafugu XP_002661405 432 ----dttndtkssINKLQSLQADYLDAASALLFEVVVLCQEASRTPALG---------------HFLTIGWVFRLLKPHP 492 zebrafish XP_023374177 463 qlaadsTLVEMSFDAKLQKLILEYTDTATALVYEILLVSQQGNLGLGS----------------TEFAISWVMSFLQSCP 526 small-eared ga...
EDO38227 876 E-AEAFVKRMMdRQMSVVLSDRK--PLSTKSAVLVYRQLYILHNLLEYSHPMASAIPRSYSEEFRYYI---KRH-IEKKL 948 starlet sea an... XP_002108932 480 EkSENFIKRIT-DAALEKLSNTGneFLSPLEIAQLYQKFTILSTLIQNSKKFAEYIKCNYAEEFKYFV---QTPlLQQKL 555 Trichoplax adh... XP_002594428 539 Q-SVSFINSLV-ASAMRLLSPSTplPLSPSQAILVFQQFYLLSTFIQYGSSLANHIRDNFTEEFRYFI---TWPvVQEKL 613 Florida lancelet NP_796309 524 P-IMAFVARIV-EGVVRGLSASFq-LLTPCQAVLLYQQFYILRSCLQHSKALAEYIRNDHREEFRYFI---HMPaLEQRL 597 house mouse XP_002687699 526 P-IITFVASIV-KQVVKGLSASFq-LLSPGRAVLLYQQFYILKSCLQYSKTLAEYIRNNYREEFRYFI---HMPaLEKRL 599 cattle 6_pfamImport 523 Q-MLSFMGYQV-QQVVQVLSDPQesFLSPLQSVLLFQRCRLLLACLQYNEQLAQHLRSHFREEFRYSV---KLScAEEKL 597 XP_004083337 466 H-LASFISYQT-QQLVLAMVGLQdsLPSAADSVLLFQRCRLLLACLQHSSQLAQHLQSHFREEFRYIV---KPLcAEKLL 540 Japanese medaka XP_031586180 585 H-LLSFIGYQV-QQVVLILTGLQgsVLSPVQSVLLFQRLHLLLACLQYNSQLAQHLRSHFREEFRYSV---MPSgSEVKL 659 Oreochromis au... CAG04183 459 H-LPSFLGYQV-KQVVLVLSDLQggPLSPAQAVLLYQRCGLLLACLQHNNQLSQHLRSHFREEFRYFV---KPScAEEKL 533 spotted green ... XP_011611599 501 H-LLSFLGYQV-KQMVLVLSDLEdsSPSPAESVLLYQRCRLLLACLQSNNQLSQHLRSKFREEFRYFL---KPScAEEKL 575 torafugu XP_002661405 493 F-LLPFVGYQA-QQTVLVLSGPQf-PISPSQAVLLYQRCCVLLACLQHSPCLSKYIRTGFKEEFRYYVktaDLE---DKL 566 zebrafish XP_023374177 527 P-TITFVANIV-RQVVKGLSAPEq-QLSPRQAVLLYQQLSILRSCLQHSWTLGEHIRTDHREEFRYFI---HMPaLEKRL 600 small-eared ga...
EDO38227 949 PIQFPLTMPTLSLLSHVSD 967 starlet sea anemone XP_002108932 556 LGKYPLSVPTYKLINTIME 574 Trichoplax adhaerens XP_002594428 614 PMYYPISRPAQKLIRQVTI 632 Florida lancelet NP_796309 598 PGCYPITEPTTQLCHEVLQ 616 house mouse XP_002687699 600 PLCYPITQPTTQLFHEVLK 618 cattle 6_pfamImport 598 PPHYPISQPTLHLLGQILT 616 XP_004083337 541 PP-YPISPPTQQLIEQILT 558 Japanese medaka XP_031586180 660 PPHYPISRPTLRLVEHIRT 678 Oreochromis aureus CAG04183 534 PPHYPIRRPTVRLVEELLR 552 spotted green pufferfish XP_011611599 576 PPHYPISQPTVRLIEELIS 594 torafugu XP_002661405 567 PDHYPISQPAQRllsqlls 585 zebrafish XP_023374177 601 PACYPITQSTTQLFREVLK 619 small-eared galago
Jiyao W et al.(2023). "The conserved domain database in 2023.",