Conserved Protein Domain Family
SmAKAP
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pfam15127: SmAKAP (this model, PSSM-Id:405762 is obsolete and has been replaced by 464517)
Small membrane A-kinase anchor protein
SmAKAP is a small membrane-bound PKA-RI-specific protein kinase A-anchoring protein, referred to as small membrane-AKAP. It is probably tethered to the plasma membrane most through a dual acylation of its N-terminal Met-Gly-Cys- motif (myristoylation and palmitoylation, respectively). It specifically targets PKA-RI isoforms to the plasma membrane. It localizes to plasma membranes, is enriched at cell-cell junctions and associates with filopodia.
Links
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Statistics
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PSSM-Id: 405762
Aligned: 13 rows
Threshold Bit Score: 108.751
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_008765367   1 MGCMKSKETFPF-PTTLDIDKLHESEEAFMPGDTCqYRTPSTDeq--------------qqVQEEVK------------- 52  Norway rat
XP_010601016   1 MGCMKSKQTFPF-PTTLENEKRHSSEENFMPEERFlPRMPSPV------------------VEENVK------------- 48  African savanna...
XP_019649252   1 MGCMKSKQTFPF-PTTFESEKRHASEESFMSEERFlPRMPSPVn-----------------V-EEVK------------- 48  giant panda
XP_003339078   1 MGCMKSKQTFPF-PTIYEGEKQHESEEPFMPEERClPRMASPVn-----------------VKEEVK------------- 49  chimpanzee
XP_003801094   1 MGCMKSKQTFPF-PTPLEAEKQRDNEVGIRPEERS--KMVSSAg-----------------VKQEVK------------- 47  small-eared galago
P0C8Y7         1 MGCIKSKQECNL-HKTIRLKRNKENDEMHNKEKVCl-------------------------VQANQE------------- 41  tropical clawed...
XP_015214771   1 MGCIKSKQNNLT-QNASSMEKADGKPKKYLDENAAl-------------------------VNSETR------------- 41  spotted gar
P0C8S0         1 MGCMKSKRRDPT-QNSDSSEKVDGKPGKH-GEKAVl-------------------------VFSEIG------------- 40  zebrafish
XP_006807689   1 MGCVKSKRSDSVaQNANSTEKVEGKSKGTRGEKAYl-------------------------VHSEMG------------- 42  Neolamprologus ...
1_pfamImport   1 MGCVKSKRSHSAsQTANSTDRNDGKGKKMKGEKAYl-------------------------VQSETG------------- 42 
EGW14480       1 MGCMKSKQTFPF-PNTL--DKLHESEETFMPDDSCqHRTPSPGkp---------------gDQEEAK------------- 49  Chinese hamster
EHB08423       1 MGCMKSKQTSPF-PTNFEMERQCGSEERFMPEDRL-CRLSSPCn-----------------AQGDMK------------- 48  naked mole-rat
XP_023617913   1 MGCMKSKQTFPF-PTTI---------------ERCePRvptpvtrdgedvedvegveeveaVEEEVQaveeakveevqav 64  little brown bat

XP_008765367  53 ---KPPVPgaviGSVILEFADRLANEIVEDALQQWACENIQYYNIPYIESES 101 Norway rat
XP_010601016  49 ---TPPEP----SVVVLEYAHRLSQEILNDALQQWACNNIKYCDIPYIESEG 93  African savanna elephant
XP_019649252  49 ---EPPGP----ETVVFEFAHRLSQEILSDALQQWAGNNIKYYDIPYIESEG 93  giant panda
XP_003339078  50 ---EPPGT----NIVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEG 94  chimpanzee
XP_003801094  48 ---GSSGT----STVILEYAHHLSQEILRDALKQWAFANVQYSDVPYIESEE 92  small-eared galago
P0C8Y7        42 ---DSKFCsctaSPLLLEYAHRLSEDIVNKAVRQWAEVDSKYSDIPYIESDA 90  tropical clawed frog
XP_015214771  42 ---QGEEGslrvNPGLLDYAQRLSEEIVAKAVQQWAEVDSRYSDIPYIESDV 90  spotted gar
P0C8S0        41 ----SMEDsvriNPVLLDYAQRLSEEIVARAVQQWAEVDSRYSDIPYIECDV 88  zebrafish
XP_006807689  43 ----SPESspqvNPVLLEYAQKLSEEIVARAVQQWVEVDRRYSDIPYIECDV 90  Neolamprologus brichardi
1_pfamImport  43 ----SVENsapaNPVLLEYAQRLSEEIVARAVQQWVEIDSRYSDIPYIECDV 90 
EGW14480      50 ---KLPEA----SPVVLEFAERLAKEIVQDALQQWACENIKYYNIPYIESEG 94  Chinese hamster
EHB08423      49 ---AEPR--------VTEYADCLSREILRDALQQWARNSIKYQDIPYIESEG 89  naked mole-rat
XP_023617913  65 eeaEEPAQpaepKVVVSQFAHRLSQEILSGALQQWADSNAKYADIPFIESDG 116 little brown bat
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