Conserved Protein Domain Family
TMX2
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cd02962: TMX2 
TMX2 family; composed of proteins similar to human TMX2, a 372-amino acid TRX-related transmembrane protein, identified and characterized through the cloning of its cDNA from a human fetal library. It contains a TRX domain but the redox active CXXC motif is replaced with SXXC. Sequence analysis predicts that TMX2 may be a Type I membrane protein, with its C-terminal half protruding on the luminal side of the endoplasmic reticulum (ER). In addition to the TRX domain, transmembrane region and ER-retention signal, TMX2 also contains a Myb DNA-binding domain repeat signature and a dileucine motif in the tail.
Links
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Statistics
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PSSM-Id: 239260
Aligned: 11 rows
Threshold Bit Score: 203.382
Created: 8-Feb-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_057043    109 DIRMGLLYITLCIVFLMTCKPPLYMGPEYIKYFND-KTIDEELERDk------RVTWIVEFFANWSNDCQSFAPIYADLS 181 human
XP_426410    154 DIRMGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSD-KTIDEELERDk------RVTWIVEFFANWSSECQSFAPIFADLS 226 chicken
NP_001002113 109 DIRLGLLYLTLCIVFLMTCKPPLYMGPEYIKYFSD-KTIDEELEKDh------RVTWIVEFFANWSPECQSFASVYADLS 181 zebrafish
AAF57540     100 DFRYGLGFLLLCVLVGMVLPEPSYRGPEHITYFRNaQVFEEELARDk------RTSWLICFYTVWNPSCVNFAPVFAELS 173 fruit fly
NP_498012     98 DILPGIIYILACLIVTVLFPEPVYNGPEQVTYFQG-EQLFEELTRNr------NTIWVIQFFTTWSPECRHTSPVFAELS 170 nematode
BAD73205     106 DYWLTVSYLLGFVVIYAVAQQPPYDGLGHSNHLTP-LQLEGLLTEEp-----tTRFWLVEFRTSFSGTCIEASSVLPELS 179 Japanese rice
CAB87682      94 DYRVAVWFSIIFSVIYLLAQQPAFSKLGTAKKLTP-MQLEDLLSDGn-----tTKYWLIEFFACSSSKCVRSSRCFPELS 167 thale cress
AAH92100     109 DLRMGLLYITLCIVFLMTCKPPLYLGPEHIKYFSD-KTLEEEMQSDg------RVSWIVEFFANWSSECQSFAPIYAELS 181 African clawed ...
XP_790165     50 DPRLAILFAAACIGCMVVFPEPAYIGPQDIVYFKG-DALEDELKNNp------RTTWIVEFMATWSASCHNIAPTFAELS 122 purple urchin
XP_319140    101 DIRLGMIYFVFFILVALLLPEPTYTGPENVLYFRTeNGLEEELEKDk------RVTWLVTFYTVWNPACVNFAPIFSELS 174 Anopheles gambi...
XP_637728    179 GLYYVLVYLFVCMLVYLYKSQPEPKQSNFVHFFNQ-ITFKNSLAFSaqskelkDKYLLVEFFTTWSPPCTYLASTFADLS 257 Dictyostelium d...

NP_057043    182 LKYNCTGLNFGKVDVGRYTDVSTRYKVStspltKQLPTLILFQGGKEAMRRP---------QIDKKGRav----sWTFSE 248 human
XP_426410    227 LKYNCSGLHFGKVDVGRYTDVSTRYKVStspltKQLPTLILFQGGTEIMRRP---------QIDKKGRav----sWTFSE 293 chicken
NP_001002113 182 LKYNCAGLKFGKVDIGRYGEVSKKYRVStsplsKQLPSLVLFQGGKEVMRRP---------QVDKKGRav----sWTFTE 248 zebrafish
AAF57540     174 AEYNTDHLKFGKIDIGRFPDVAQKYRISdssfsRQLPTVILFQQGKETDRRP---------CVDSKGKlq----kFFFSS 240 fruit fly
NP_498012    171 QKFTLPNMKFGKLDIGRWAKEGERFRVNahpmsRQLPTICVFKDAKEIARRPl--------VNDSRRAv-----pFVFSE 237 nematode
BAD73205     180 NIYSNKNISFGIIDLGHFPNAAAKFGISm---wDHLPTYILFDKATEVARFPe-------iMNESKVFv------PKITK 243 Japanese rice
CAB87682     168 ITYSNNLLSFGTVDLGLFPNTAAKFGISlaggmSQLPTYILFEKGVEVSRFPd-------fYVDAAPS-------LPITK 233 thale cress
AAH92100     182 LKYNCAGLKFGKVDIGRYPEVSCRYSISpsplsKQLPTLILFQGGREVFRRP---------QVDKKGRav----sWSFTQ 248 African clawed ...
XP_790165    123 TTYAHNHLKFGKLDVGRYPEIAEIFQVDsssltKQLPTMVLFQGGKEVMRKPgr------nKNGQTVR-------YEFKK 189 purple urchin
XP_319140    175 NEYALSNLKFGKLDIGRFPKIGEKYHVSdssfsRQLPTVILFRQGKEVARRP---------YADSKGKlv----kFFFSA 241 Anopheles gambi...
XP_637728    258 YIYQGINFGKIDIGRWKSIAYEYDIADSvs--sKQIPSIILFKNGVEVSRMPyrknefkmpYDKKTPKddklfepCNLSY 335 Dictyostelium d...

NP_057043    249 ENVIREFNLNE 259 human
XP_426410    294 ENVIREFNLNE 304 chicken
NP_001002113 249 ENIIREFNLNE 259 zebrafish
AAF57540     241 DNVRATFGLNQ 251 fruit fly
NP_498012    238 ENCVLAFDLLN 248 nematode
BAD73205     244 KLLCQHFDLDR 254 Japanese rice
CAB87682     234 KLLCQHFELDR 244 thale cress
AAH92100     249 ENVIREFNLNE 259 African clawed frog
XP_790165    190 ADIIRDFDLDR 200 purple urchin
XP_319140    242 DNVKAAFDLNN 252 Anopheles gambiae str. PEST
XP_637728    336 DNIRLYFNLDT 346 Dictyostelium discoideum AX4
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