4RG1


Conserved Protein Domain Family
Methyltrn_RNA_3

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pfam02598: Methyltrn_RNA_3 
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Putative RNA methyltransferase
This family has a TIM barrel-like fold with a deep C-terminal trefoil knot. The arrangement of its hydrophilic and hydrophobic surfaces are opposite to that of the classic TIM barrel proteins. It is likely to bind RNA, and may function as a methyltransferase.
Statistics
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PSSM-Id: 460611
Aligned: 151 rows
Threshold Bit Score: 172.766
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4RG1_A        11 TLSVALPGSILDNAQSPELRTYLAGQIARACAIFCVDEIVVFDEEGQDA--KtvEGEFTG-------------------- 68 
EJT42732      39 QYSICIPTSAIDNCFNLEQTTFTAYQIAKTAVLFNIQEIIVLDLSKDRR-----HGKRPR-------------------- 93 
P53336        39 KYSICIPTTVIDNCNNLEQVTFTAYQIARTAVLFNVQEIIVLDQSKDKK-----HEKKSR-------------------- 93  Saccharomyces c...
Q751R3        60 NYTLCIPTSILDNCANLEQVTHALYQIAKAATLFNVGEIVVLDLGTDTDaaAphLAASELeprkrkikfedvtektetsn 139 Eremothecium go...
XP_003684072  54 NYSICIPTSITDDCKNLEQTTNVIYHIAKTATIFNVGEVIILDLGKETP-----IEVTEDikgt---------------k 113
XP_002495714  38 NYSLCIPTTLLSHCKNLEQVTYTVYQVAKAATMFNVGEIVVLDLGTTSG-----TTKE---------------------- 90 
CCD26827      58 NYSLCIPTSVISNCTNLEQITYTIYQIAKAATFFNAGEIIILDLTSPPN-----TDDTQLktk----------------- 115
XP_004357789 182 TRSIAIPNDILDDFASEEMKTYLVEMIARTLVLFSIDEVIVYRSTKSTNs------------------------------ 231
Q54LQ0       161 TVSIAIPSNALSGIQSEEMKTYIIEMISRQVTMNKIDEIIVFKTDDYNEedSqqQ------------------------- 215 Dictyostelium d...
O13641        17 TISLALPISSLNVAYNLQLKTSFVWKISRIVSLYGIDEIILLEDPEYVQntQvhTLSSD--------------------- 75  Schizosaccharom...
4RG1_A        69 --VGKKGQACVQLARILQYLECPQYLRKAFFP--KHQDLQFAGLLNPLDSPHHM-----RQDE-ESEFREGIVVDRpTr- 137
EJT42732      94 --SKETISDCLLLATLLQYFVTPSNLLDITFKrkNMLYLKHAFAFPKLHQLAFM------NESaEHIYREGLSIAQdNa- 164
P53336        94 --SKETISDCLLLATLLQYFVTPPNLLDTTFKkkNKLYLKCASTFPPLNQLPFM------NASaEQHYKEGLSIARdSs- 164 Saccharomyces c...
Q751R3       140 kkSASRLSGAMLIATLLQYFVTPRYLVSSVFKkkYSSYFNCAAKLPRLSALPFMrh----lqTdQGRYREGLSVNMaKp- 214 Eremothecium go...
XP_003684072 114 geTKKRLSRPMLIATLLQYFVTPPYLVNTVFKkdYHKYFKYACKLPRLSVLPFMry----yeEdKGRFREGLAVRMsKpe 189
XP_002495714  91 ----KKLSDSMLIASLLQYFVTPPYLVNTVFKqkYLSYFREACKLPRLPSLPFMry----lqAdEGRYREGLAIRMsKpg 162
CCD26827     116 kkSTTKLSDSMLIASLLQYFVTPPYLVNSVFKkqYRQYFHEASKLPRLSALPFMryldhGEGNdNHRYREGLAIRMtKpg 195
XP_004357789 232 --------TTDKLCKLLEFIDLPKNIRHHLYDl-NDIDYQFVDKLKRVESGQHA-----TSNR-WTKYREGIVLDKlSg- 295
Q54LQ0       216 -------SDLNLLLKVLEYIETPSYLRDELFNt-LEKDYFNVDKLNSINSCQQ------QQPNdEQLYREGVVTNQhWk- 280 Dictyostelium d...
O13641        76 ---AYLKDPTKFLTDLLCYFETPFFMRKELFP--LNPHLKYTSCFPLLP----LrndkaSTVNiEFPYREGIVTHPsPq- 145 Schizosaccharom...
4RG1_A       138 --------pGHg------SFVNCGm--KKEVkIDK---NL-EPGLRVTVRLnqqqhp---------------dcktyHGK 182
EJT42732     165 --------eKEier-dqtNLVYIG---KGEI-IELsnqNI-PRTVRVTVDLq-------------------------RKE 205
P53336       165 ---------KGksddaltNLVYIG---KNQI-ITLsnqNI-PNTARVTVDTe-------------------------RKE 205 Saccharomyces c...
Q751R3       215 --------aAAkkpstrtKYINIG---KDTM-LELrsqQV-PVNVRVTVDTv-------------------------NKN 256 Eremothecium go...
XP_003684072 190 atnsnqsnsKKakefkqtKYINIG---KSEC-LELksqLV-PVNVRVTVDTv-------------------------EKR 239
XP_002495714 163 t------qgKKtkefkqtKYVNVG---KSEA-LELkaqLV-PANVRVTVDVv-------------------------ERK 206
CCD26827     196 k-----istSNkkefkqtKFINIG---KDIN-LELksqLV-PINVRVTVDTi-------------------------EKR 240
XP_004357789 296 --------kFS--------LVDVGlgdGKEIkIDK---EL-QAGIRVTLEMeeehgkqi-----------nnanqhrKGK 344
Q54LQ0       281 --------nQS--------IVNVGl--EKLVlIPK---RL-NPGTRLTIDIknssngdddgtggggdgnretndkyiNGK 338 Dictyostelium d...
O13641       146 --------aKNk------yIINAGl--SHNViVSSp--SVlAPRTRVTVRLkaqspn---------------eegqlQGD 192 Schizosaccharom...
4RG1_A       183 VVSSQDPR---TKAGLYWGYTVRLASCLSAVFAEAPFQD--GYDLTIG-TSer----------gsDVASAQLPNf----- 241
EJT42732     206 VVSPRDVY-----KNQTLGYHVRVASTLDEV------SE--GYARTLWvNSgdyhyde-elskyrKVETKLPYImkikkg 271
P53336       206 VVSPIDAY-----KGKPLGYHVRMASTLNEV------SE--GYTKIVWvNSgdfhyde-elskyhKVETKLPYIaklkks 271 Saccharomyces c...
Q751R3       257 VVSPAEAYgdySGANAAYGYSVRVARTFADIFLGAGFAG--GYTQSLWvNSadfffdp-aaqssvRLDSKIPHVqkiikp 333 Eremothecium go...
XP_003684072 240 VVAPQEAYgdyVGAQSSFGYHVRVCKKFGSVFTESAFPE--GYSQAIWcNSgdyyyne-klkkndSIENELPRIqsivks 316
XP_002495714 207 VVSPKEAYgdfVGAQSSYGYQVRIAKNFGDVFMESAFAD--GYSQALWvNCddyy------yneeKQRKLLPFVdrivrp 278
CCD26827     241 VVSPEEAYgdfVGAQASYGYHVRIAKSFGDIFTHCAFRN--GYSQSVWiNSgdyyyne-slkkymKIDSKIPTIskiitg 317
XP_004357789 345 VVSPAEVR----HDGHYWGYQVRSVDSIDNVFQDSSFn---AYDYKILfTCnshdnqevqdlkqqRLKEKQDIFdnnl-- 415
Q54LQ0       339 IISPSDIK----KEGYYWGHHIRLVDSLAKVASTCQYEDtqNYDYIIM-HSqygeqfpsyt------------------- 394 Dictyostelium d...
O13641       193 IVSFSAPR---EKGGHYWGYKVRSCLS-SQLCKSSPYKG--GYDFVVQiNSqts---------aiTSKELEASLps---- 253 Schizosaccharom...
4RG1_A       242 ----------------RHALVVFGG-LQGLEAGA----------------------DADPNL-----E-VAEPSVLFD-- 274
EJT42732     272 ----------svsetpCNILLIFGK-WDHLKRCF----------------------KRSDLE-------CSALHRYFS-- 309
P53336       272 ----------stsekpCNILLIFGK-WGHLKRCF----------------------RRSDLE-------SSSLHHYFS-- 309 Saccharomyces c...
Q751R3       334 slee---lheqpsvqpANLLLVFGK-WKHLSDKF----------------------QQTkd----qfDgASGAHDLFD-- 381 Eremothecium go...
XP_003684072 317 ekktsengdetpaaqmSNLLVLYGK-WKHILESF----------------------EASke----mfEgCSGPHEFFD-- 367
XP_002495714 279 e---------tasqnvSNVLLVFGK-WRDVQKSF----------------------TASkd----qfEgVEGAHQFFD-- 320
CCD26827     318 sat----edatkkvdaANLLMVYGK-WDHIKQSF----------------------NASkd----qfEgCEGAQDFFD-- 364
XP_004357789 416 -------------esqQHVLIIFAErEQQILDLLkqlpiekedekeedenedkeeeKKED---------GEKKEKKLDks 473
Q54LQ0       395 ------dvvinnakkyNHLLVIFAD--ANASSTV----------------------NPEFKLgsevlVpDTHINTLVD-- 442 Dictyostelium d...
O13641       254 --------------sfRHAVLVLQDnVVQKELVD-----------------------------------STAKSISFNpf 284 Schizosaccharom...
4RG1_A       275 --LYVNTcpg--qgSRTIRTEEAILISLAAL 301
EJT42732     310 --GQLHFpgt--vpQGKLAIQDGLQIALTML 336
P53336       310 --GQLQFpas--vpQGNIPIQDSLPIALTMF 336 Saccharomyces cerevisiae S288C
Q751R3       382 --GRLDLpg---apEGYICIEDSCMVALATL 407 Eremothecium gossypii
XP_003684072 368 --GQLELpga--apRGMIPISDCCTISLTLL 394
XP_002495714 321 --GQVGLpg---glEGCIPIQDACMVSLAVA 346
CCD26827     365 --GQFELpgm--vpQGNVPIQDACMISLSSI 391
XP_004357789 474 ldKIIDLqsdntlkSKRVRFEETLLIGLSSL 504
Q54LQ0       443 ----FNI--------KKLRFEETLSITLSKL 461 Dictyostelium discoideum AX4
O13641       285 pvSFLNDpi----------pEEILLAAMTRL 305 Schizosaccharomyces pombe 972h-
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