Conserved Protein Domain Family
EIF4E-T
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pfam10477: EIF4E-T 
Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E
EIF4E-T is the transporter protein for shuttling the mRNA cap-binding protein EIF4E protein, targeting it for nuclear import. EIF4E-T contains several key binding domains including two functional leucine-rich NESs (nuclear export signals) between residues 438-447 and 613-638 in the human protein. The other two binding domains are an EIF4E-binding site, between residues 27-42 in Q9EST3, and a bipartite NLS (nuclear localization signals) between 194-211, and these lie in family EIF4E-T_N. EIF4E is the eukaryotic translation initiation factor 4E that is the rate-limiting factor for cap-dependent translation initiation.
Links
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Statistics
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PSSM-Id: 371079
Aligned: 8 rows
Threshold Bit Score: 420.957
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ACY70537       10 YSRSDLLALRHEGSSRERPHCANRTELQTLNFWKinviqsnnns------nsygnktglsPERESSSLTIS--------- 74  
XP_015032358   10 YSRADLLALRYEGSARQRPSCSNQTELQTLGFWKngvlsvgsgssgcgisggtygnsclsPETDNSSLSSSn-------- 81  
Q8IH18         10 YSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKinlntaaltvss---aysnqnknrlsPEADNSSLICSn-------- 78   fruit fly
EDW25266       10 YSRADLLALRYEGSSRQRPQCANRNELQTLNFWKvnasanvpsn------yanpnkislsPETDNSSLSSSn-------- 75  
EFX87805       43 YSRDLLIKLKNHPSSKEKPAIFDDLDRVKNGMWD--------------------------PEHWHSRTAKEpkr------ 90  
PNI98010       30 YTKEELLDIKELPHSKQRPSCLSEKY-DSDGVWD--------------------------PEKWHASLYPAsg------- 75  
XP_005987194   28 YSKEELLEIKEGPHSNLRPLCLLGKY-DSDGVWD--------------------------PEKWHASLYPSsg------- 73  
XP_015785233   41 YSKEELIEISKQPYCGKRPKFLDPDYVNKSGLWD--------------------------PDLWMNYKNPSnkpipsslp 94  

ACY70537       75 -------------NGLLSSRRALRNRERAHNYYQRFSSSDQIGGedvqvslasatgnlcasykspkidhrsissshlmpa 141 
XP_015032358   82 -------------NGLNSSRRALRNRERANTYYQRFAPNDSQLGcddrerdrdrerdrdrererdtqsannittisfkss 148 
Q8IH18         79 -------------SSSISSRRAMRNRERANNYYQRFVPTDSLLIsgedkdkdalshgqpyklniidhrsiss-------- 137  fruit fly
EDW25266       76 -------------NGLISSRRAMRNRERANNYYQRFAPSDSHSMciedkdkdtqstqsvlggppfkssiidhrsissshl 142 
EFX87805       91 -----------snSGTVVGAGNKEDQQEKK-------------R------------------------------------ 110 
PNI98010       76 ------------rSSPVESLKKELDTDRPSLVRRIVDPRERV-------------------------------------- 105 
XP_005987194   74 ------------rSSPVEGFRKDQDSDRAILKRRIADPRERV-------------------------------------- 103 
XP_015785233   95 strdhdlsapgltNKNIRGPPKRVNGESESSLRNRKDPRDRVK------------------------------------- 137 

ACY70537      142 fakkrfviasgeridqnesqnektnasvnyedgkmnakentatpahanidlknHLRAINSSLGSPIRRGSpirraPAPge 221 
XP_015032358  149 sidhrsissshlmpafakrrfaaaaesseltsnnansddyisgvernvtptllNKESKRNSLVSPVPKGS-----GGC-- 221 
Q8IH18        138 -------------------------shlmpafakrrfviskgsnseesneginTCASKGKAASSPSRKGSeldtaETCln 192  fruit fly
EDW25266      143 mpafakr----rfavvncgngtenepintncddiavgenvtveldhthvstptHNQSQSKGMSSPIRKASew--gESCer 216 
EFX87805      111 -----------------------------------------------------GKEEGDEFCFTPQRRSFv----SGChv 133 
PNI98010      106 ------------------------------------------------------KEDDLDVVLSPQRRSFg----GGC-- 125 
XP_005987194  104 ------------------------------------------------------KEDDLDVVLSPQRRSFg----GGC-- 123 
XP_015785233  138 ------------------------------------------------------EESQDDIVLSPQRRSFg----TGChi 159 

ACY70537      222 wergekhsnpqENEQTLALSPTFSSGRqvgs---------lnvQ--------ERRIGSGRLLPRtdnwEYKNKD--ADIL 282 
XP_015032358  222 -----------DHEHSLASSPTYSSAR----------------H--------ERRIGSGRLLPRndnwEFKKQEtdTDSA 266 
Q8IH18        193 f-------vqpDHDQCMSSSPTFSTSR----------------Q--------ERRIGSGRLLPRsdnwDYKNEK--TVEA 239  fruit fly
EDW25266      217 rsn----nvqqDHDQSLASSPTFSTTR----------------Q--------ERRIGSGRLLPRadnwDYKGQQ--QSSS 266 
EFX87805      134 v--------rrQDAEPAVPPVVTESVRest--------------------lpARRVGSGRLTGR----DVEPAPvpAKEP 181 
PNI98010      126 ---------------HVTAAV--SSRRsgsplekd-sdglrllG--------GRRIGSGRII------------------ 161 
XP_005987194  124 ---------------HVIASAGPSSRRagspqenkenenlrglG--------GRRIGSGRLS------------------ 162 
XP_015785233  160 v--------pvRNEQPVATGTQAQRSSvgkadnhahqqdrreeQllhrndnvNRRIGSGRLL------------------ 213 

ACY70537      283 LNNHEKDRPENGSLA----------NQQRQRTSSGKHSERTSdyvgerDRDRDRRlnerkgidnRDQNDGKKMVQT---- 348 
XP_015032358  267 VVEREKDRERPHNGSmlq-----ssNQQNQRTYSGRQNDREF------GGDRDQR---------RSQYEGKRPLDRptgv 326 
Q8IH18        240 SIENEKETSPNGSGStssln-qhnqSQHRSRTFSGRLVERVPe-----VTDR------------RFQYDSKKSFDRqg-- 299  fruit fly
EDW25266      267 GIEKEKERSQNGSGSinqqnqsqnqNQQRPRTFSGRHGDRLTe----hIGDR------------RFQYDNKRSVDRqg-- 328 
EFX87805      182 RDRREPLRAPAPQRErtfdrepqrnERGNERNDRHDRNER----------NERSErngrtfqpsRADPRDKDPAEK---- 247 
PNI98010      162 --------------SartfekdhrlSDKDLRDLRDRDRER----------DFKDKrfrr--------------------- 196 
XP_005987194  163 --------------SsrgyerdgrpGDKDTRDARDR--ER----------DFKEKrfrr--------------------- 195 
XP_015785233  214 ---NQRDKSNLEWSKsrdreeeienRRSNLRYTNGNSNNSGRy-----DYDRRSSmnnr--------------------- 264 

ACY70537      349 -------------GRRTSNKDKFNFGdsniqSRGKRMNIYQTHD---RPEPEWFSAGPTSQHETIDLHGFDD-------- 404 
XP_015032358  327 gnttgsgavgglsGRRISNKDKFSFNd---vGRGKRGSSYHQMQdrhHKEPEWFSAGPTSQLETIDLHGFDDl------- 396 
Q8IH18        300 -----------inNRRISGKEPFSTQ-----SRSKRGNSYLIHE-----EPEWFSAGPKSQLETIDLHGFED-------- 350  fruit fly
EDW25266      329 -----------vsSRRSSNKDSGCIQ-----GRGKRTNMYHQHDr--HEEPEWFSAGPTSQLETIDLHGFDD-------- 382 
EFX87805      248 -------------DRRNFDRSGYDRDysgrgDRGDRYNSRRKNE---DDTPEWFFGGPSSQHDTIELRGFDE-------- 303 
PNI98010      197 ----------------------------efgDSKRVFGERRRNDsytEEEPEWFSAGPTSQSETIELTGFDDki------ 242 
XP_005987194  196 ----------------------------dfnDGKRGYGDRRRNDsytEEEPEWFSAGPTSQSETIELIGFDDkl------ 241 
XP_015785233  265 ---------------------------------rygHHDRRDSRnheEEEPEWFTGGPTSQHDTIELKGFEEempedevs 311 

ACY70537      405 --FEGESSANLKIVKEDASKELDLKTNQAATPTSRS-----SSIASLNVVESNSNNKKDSDSDITMSNVapsiqnh---- 473 
XP_015032358  397 --ENSNESRTSESKKDRACNALPVDTDKQIDHETMSk---nSSSVSLNLLETKTGDDVKDVDMNTLEAVnfrlsqkesd- 470 
Q8IH18        351 --LEKNEERSVTEDKNNQIQQLDKNLDAQASKDEASm---rNSNDSLNFREVIPSDEKKHTDENVVTSIqnstdlghpnk 425  fruit fly
EDW25266      383 --HDHNDERSEFEDKANRFPSKPSQLAEPIVVDGASt---sSSMSSLNVVDVKTKDDNKDTGESVIQPQleptqqsknhq 457 
EFX87805      304 --EKDRKQNSKAPIRKESNKERQQSSGAKKSEEPSTsssrpGSGLSGKVVKEDQPPKTEAPKRKSPVNQ----------- 370 
PNI98010      243 -lEEDHKGRKRTRRRTASVKEGIVECNGGVAEEDEV-----EVILAQEPAADQEVPRDAVLPEQSP-------------- 302 
XP_005987194  242 -iEEDRRRFKRSRKRTDSFKD--LECNGGVVEE-EV-----EVAISPDAVADQEVPQATVLPEPAP-------------- 298 
XP_015785233  312 kgRQNHHRPQNQHVEPESRGQGSLINNGDVKEHFEN-----HNHYKSNGVEEHESGSKEI-------------------- 366 

ACY70537      474 ----nvqaipkTDVEFNFDAFLNMDPMDHALMGNDSE-------------VQGDVKGTSRFSQWFAPK------------ 524 
XP_015032358  471 -qliklqhasnPEVEFNFDAFLNMDPLDNSLIGNDADmp----------gAEISGFGKSRFSRWFGPN------------ 527 
Q8IH18        426 nkpiqmqpsqnPESEFNFDAFLNMHPLDNSVLSNDET-------------GKSDSKGTSRFSRWFRQK------------ 480  fruit fly
EDW25266      458 -qsgrlpctsnSEGEFNFDAFLNMHPLDPTLMSNDGD-------------EQDETKGTSRFSRWFRPK------------ 511 
EFX87805      371 -----------DKMDFNIEDFLKMDGDLNGLGLGPTE--------------SEETSRGSKASRWFGK------------- 412 
PNI98010      303 -------------GDFDFNEFFNLDK-VPCLASMIEDv------------LGEGSVSASRFSRWFS-Npsrs-------- 347 
XP_005987194  299 -------------GEFDFNEFFNLDKSVPGLASMIEDv------------LGEASVSASRFSQWFSSNlsqs-------- 345 
XP_015785233  367 -------------QDFDINEMFKFEGWKNIVSMSPENvtsipgftdpnvsGQNQNGGTSRFAQWFNVSrtetespidrll 433 

ACY70537      525 -----EPA--NTNDQLYFGH-----ASTPDTQEI-----------------------P---------------------- 547 
XP_015032358  528 -----ESTknNNEESPKRRE-----ANTPDIHGI-----------------------P---------------------- 552 
Q8IH18        481 -----EAA--NNNEFPGFRE-----SHAQEKRGI-----------------------P---------------------- 503  fruit fly
EDW25266      512 -----EAA--NNNEPSGLRE-----SGAQETHDI-----------------------P---------------------- 534 
EFX87805      413 -----TSDlpEASKPPATENvkpdhSTNQDAAR----------------------------------------------- 440 
PNI98010      348 --gsrSSSlgSTPHEELERL-----AGLEQAILS-----------------------Pgqnsgnyfapi----------- 386 
XP_005987194  346 --gsrSSSlrSTPHEELERL-----AGLEQGISS-----------------------Pgqscgnffapiq---------- 385 
XP_015785233  434 qnvtfSSSynAAPHDSRR-------SSVQEIERTlfnhnhlgngshridptvlglrnPetynghhhhngghintngteng 506 

ACY70537      548 -------------SVKDLeAQMRKVDLRpendiinaTANAHPTI-------HTEQRDKAV-------------------- 587 
XP_015032358  553 -------------SVKDLeAQMTKVDLN--------TAMAMPPQ-------AVSDVEKPV-------------------- 584 
Q8IH18        504 -------------SVKDLeAQMIKVDMR--------TDLINPIAgs---lcQTVQMEKPI-------------------- 539  fruit fly
EDW25266      535 -------------SVKDLeAQMTKVNLR--------SEYTNPIAvay--ggQQAQVEKPV-------------------- 571 
EFX87805      441 -------------SLLEM-LQKGSQQQQ---------------SvehkkivTAEELERssgkys---------------- 475 
PNI98010      387 ---pledhaenkvDILEM-LQKAKVDLKpllsslsaNKEKLKESshsgvvlSVEEVEAGLkglkvdqqvknstpfmae-h 461 
XP_005987194  386 --sesteksenkvNILEM-LQNAKVDLKpllsnltaNKEKLRESthsgvvlSVEEVEAGLkglkveserkiatpfmaeql 462 
XP_015785233  507 ahghndspvnkgkDLLNL-LQKANININdl----mqQQSSLPTLpkfeharSVEEIEAGLrsfpisgsn----------- 570 

ACY70537      588 ----------------TKDTEAFKRLL-QQLGSQNISHPGTESSNPMNAVVRSGQSSNtqdrqqhiirvqenqike---- 646 
XP_015032358  585 ----------------TRDTEAFKKLL-QQLGAQNMQQGHEQEAATDLFQMMRGPNAIpqnahqlnhphlmdgqqnfavr 647 
Q8IH18        540 ----------------ARDTEAFKKLL-QQLGSQARQHHPCNDDCRTINLSNIANHVH---------------------- 580  fruit fly
EDW25266      572 ----------------ARDTEAFRKLL-QQLGSQSNQHQLGNDVYHMINTSNAHQCANqnthrphlidpqqnilrdh--- 631 
EFX87805      476 ----------nnerssDDGMTVFNKLL-AQVQESTTKPHSVMNSAPTEQDILANLLGKqmkie----------------- 527 
PNI98010      462 leetlsavtnnrqlkkDGDMTAFNKLV-STMKASGTL------------------------------------------- 497 
XP_005987194  463 eealtsvagskpvrkrDGDMSAFNKLV-NSMKESGTL------------------------------------------- 498 
XP_015785233  571 -------qhdgnqqdkNVEHSDFNRLLlKAMSRRGTQ------------------------------------------- 600 

ACY70537      647 -----delqlyqqqhskkidtaPQRHIEMISQNQMHPVLTPGVHDSNIsgllplQAHKRME------------------- 702 
XP_015032358  648 tdvevqpflqqqhqqqrlklleNLPPHRIVESLAPQQPNSVHGPTPNIh----vQTQKRME------------------- 704 
Q8IH18        581 ----------------------LESKLHQKINDGHLQQPELSVNVPTMptsshvFLQKRLE------------------- 619  fruit fly
EDW25266      632 ---spqikeedtelfqqrfkhsDCMPKRINEAMVQQQHTIQGVHTPNIa-----LAQKRME------------------- 684 
EFX87805      528 ------------------aqppQPVQYHAQQNHQDALAKFLQQQQNNQ------MHHPNTQ------------------- 564 
PNI98010      498 ------------------------------------------------------PSQPKVS------------------- 504 
XP_005987194  499 ------------------------------------------------------PMQPNVHrnseprllppnevraqplp 524 
XP_015785233  601 ------------------------------------------------------FVNPNSK------------------- 607 

ACY70537      703 IQQLLQGVVRGDVSIEFLNKELNN--------PNTTHQ-------------SREVI-----------------AAVLHEC 744 
XP_015032358  705 IQHLIQSIFRGDISLEFLEKELSN--------PNTTAH-------------TKDVI-----------------AAVFREC 746 
Q8IH18        620 IQHLIQRLHCGDVSHDFLEKELDN--------PSTPAA-------------TKDVI-----------------ATVLNEY 661  fruit fly
EDW25266      685 VHHLIQGIARGDVSVEFLEKELSN--------PSTVPH-------------TKDVI-----------------ATVLREY 726 
EFX87805      565 QHNTHQMLQQPQINHLHQQQQQSHlfsmhgeqPHSDVH------------------------------------SLMRDL 608 
PNI98010      505 ------ELLGQPVQRPASSNLLSGlmgsleptTSLLGQrapspplsqvfqtRAASAdylrpripspigftpgpQQLLGDP 578 
XP_005987194  525 QKNLLQEILGPQIPRSISPNILSSlmgnadhtAALLGHrglsppvsqlfqhQPRSPdyltgrip-spigfvpgHPVLADQ 603 
XP_015785233  608 APVVIPLNVRPPIHLPGKPQFVN--------------------------------------------------------- 630 

ACY70537      745 SNSGRNTVQHLPytndihPHNLVKNHQLFNKNIGP----------EDVFTQN-----------TPSQGINQHQR------ 797 
XP_015032358  747 SNARRNSMPPKQt----yQNDVIGGHSNLNAGLPPyhqtlgpnisEELFTPNl----------PSNPNMNHHIR------ 806 
Q8IH18        662 SHSKRNPVVt-------gDPNIFTQQSFLQPqsvh------qhysQELHSQN-----------TANHTINQLIS------ 711  fruit fly
EDW25266      727 SSSRRNSLAYKPaypnemDHHSLAHLSFHQAqpqh------qnysDDLFPQN-----------SSNHGISQHIR------ 783 
EFX87805      609 ANGHPQTLN---------QLHMMTMQKQHQQQQQHlqqqqqqqlqQYQQQQQ--------------QQRQAFVGspqqsv 665 
PNI98010      579 FQGMRKPMSPIT--------AQMSQLELQQAALEGlalphdlavqAANFYQPgfgkpqvdrtrDGFRNRQQRVTkspapv 650 
XP_005987194  604 FHGMPKAMSPVP------PQQVLSPLEMQQAVLEGlsfpqelalhSGNFYHPgfskyyldkgrDGYRNRQLRMNrspgpv 677 
XP_015785233  631 -------------------QNFVGPQFVNQNFVQPvv------------------------------------------- 648 

ACY70537      798 ---HSNSPTP---------LAFTPTSVLRKMTADKES 822 
XP_015032358  807 ---HSNSPTP---------LAFTPTSVLRKMTADKDT 831 
Q8IH18        712 ---HGNSPTP---------LAFTPTSVLRKMTADKDT 736  fruit fly
EDW25266      784 ---HSNSPTP---------LAFTPTSVLRKMTADKDT 808 
EFX87805      666 akqSASSSSP---------LSFTPTAVMRKMGAEKDK 693 
PNI98010      651 hrgNSSSPAPaasitsmlsPSFTPTSVIRKMYESKEK 687 
XP_005987194  678 hrgNVPSPAPasit-smlsPSFTPTSVIRKMYESKEK 713 
XP_015785233  649 -----------------ipLNFTPTSVIRKF-AEKDK 667
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