Conserved Protein Domain Family
MTP18

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pfam10558: MTP18 
Mitochondrial 18 KDa protein (MTP18)
This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.
Statistics
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PSSM-Id: 431357
Aligned: 76 rows
Threshold Bit Score: 170.112
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016292124  81 ERYAAYFMRLKTVIIASSRYVAYTSDIGEAFRPLTKPAVVKAAYGISWTYILGDVFYAGYKAAKQYEALASttfTSSSGP 160
EFC35371      38 LRYLGYLGRLKTAIVAGARYLAYTSDVGEAFRPIVHPLIVRAGYGISWAYVLGDVGIQTYREKEKGSSTNT--------- 108
EDP43569      25 gRYSAYTMRLKTLVTSVSRYIAYTSDVGEAFRPLTRPIVVTSAYAISWAYIFTDVGWTCWQAAKLQDR------------ 92 
GAC75419      83 SRYAAYAMRLKTVIVASSRYVAYSSDIGEAFRPLTSPAFVRGAYAVSWTYILGDVVYAGYKAAQQYEALASttfSKSGPV 162
XP_012191542  85 gRYAAYAARLKTAVGSSLRMSAYTSEMGEALRPLTKPWVVRGAYAVSWTYIIVDVAYAGFKAAKQYESLASttfSATGPV 164
EGF76981      10 LRILGYAGRLRNFVTAGSRYLAYTSDMGEAFRPVVPRSVVNAAYGVSFAYVGIDVAYEGYKSSLRGDSPME--------- 80 
EFP75483      24 ARYLGLVARIRPLLIPASRYLAYTSDVGEAFRPVVNPKVVTSAYGISIGYVVGDVAYEGWKGHLQAQGDPD--------- 94 
KDE03011      31 ARYLAYLARIRPVLQPMTRYLAYTSDVGESVRPIVNPKMVTGAYGVSWAYLVGDVAYEGYKARLRANENCP--------- 101
Q5KIX6        45 IRYAAYLRRARDVVRAGSRYTAYTSDVGEAFRPVVPPWLVTAAYGVSWAYLIGDVSFTTYKSSQLGPSPIEaanMSERTR 124 Cryptococcus ne...
EKC99431      41 VRYAAYLRRIRDVARAGSRYTAYTSDIGEAFRPVVPPGVVTAAYAISWAYLIGDVSFTTYKAKEQGPTPWEaanFSEPTR 120
XP_016292124 161 LQELEteaaryadkalssvkqnlpleklldhktlstlsptekvelrkrhtqrlaeaGQHAGVDPNQISEVTHVGL-T--- 236
EFC35371     109 ----------------------------------------------------------------------------Vlrt 112
EDP43569      93 ----------------------------------------------------------------DSPTLASDIAW-I--- 104
GAC75419     163 QELESeaaqladkaltsarenlplekllda-ktlnalsptekvelrkrhverlaeqGDHAGVDPNQVSEATHVGV-V--- 237
XP_012191542 165 QELETeaaklanqtlssvrenlpleevlds-ktlsalspsekvelrkrhtqrlaehGRHAGVDPSKVSEVTHVGM-T--- 239
EGF76981      81 ----------------------------------------------------------------------------Vtrt 84 
EFP75483      95 -----------------------------------------------------------------------DNLV-Ialk 102
KDE03011     102 ----------------------------------------------------------------------EAVSTvVgln 111
Q5KIX6       125 -------------------------------------------------------------LAM------------V--- 128 Cryptococcus ne...
EKC99431     121 -------------------------------------------------------------LGL------------V--- 124
XP_016292124 237 MARQAVFQSIASMALPAFTIHSIVRYSAP-LFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 303
EFC35371     113 ATKTAIFQSTASMILPMITIHQTVHVVSA-ILKKVgyKSKVI----PTISGLAVIPALPFMFDHPVEHFV 177
EDP43569     105 AARRGAFQSLASLVLPAVTIHSVVKHSAH-LFAKF--KSSRVRVAGPTAAGLLVVPLLPIVFDDPVETVV 171
GAC75419     238 MARRAVFQSIASMALPAFTIHSIVRYSAP-VFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 304
XP_012191542 240 VARQAVFQSIASMALPAFTIHSIVKYTAP-VFAKA--KNHRIRAFGPTAAGLMFIPALPFLFDEPVEHVV 306
EGF76981      85 VVERTIFQGLASLLLPAITIHSVVDLTTK-ALKNT--SINALKRWGPTAAGLAVLPVLPILLDRPVEYVM 151
EFP75483     103 VARRAAFQGTASMLLPALTIHSAVRYSKKmIFSKM--ANPRIHSIGPTAVGLGIIPFLPTLFDEPVEHLV 170
KDE03011     112 VAKRAIFQCVASMLFPSLTIHAIVRYTAI-AVKKAnvKSIAVRRWLPSALGLGFIPALPFIFDEPVEHVV 180
Q5KIX6       129 AVKRSVFQGVASMALPAFTIHTAVRYAGR-AFAKS--QNAILRRWGPTAVGIGIVPALPYMFDHPVEQAt 195 Cryptococcus neoformans
EKC99431     125 ATKRSVFQAVASMGLPALTIHTAVKQASK-LFANS--ANASLKRWGPTAVGISIVPALPYLFDHPVEVVt 191
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