Conserved Protein Domain Family
SARG

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pfam15385: SARG 
Specifically androgen-regulated gene protein
This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.
Statistics
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PSSM-Id: 464692
Aligned: 21 rows
Threshold Bit Score: 396.081
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_023103630  33 SGSSDCSYDFLSAEEKECLLFLEETIGSL-DTEADSGLSTDESEQDTAP---RGPRALPV-TQPAPQgypgekiipqgpE 107
ELW47758     292 SGSSDNSYDFLSAEEKECLLFLEETIGSL-DTEADSGLSTDESEPATTP---RSFRALPI-TQLAPE------------E 354
EGW00962       9 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSP---RSFRALPI-TQQAPQgnpevtdiqqvpS 83 
Q8BI29        33 SGSSDSSYDFLSAEEKECLLFLEKTIGSL-EAEADSGLSTDESEPATSP---RSFRALPTaTQQAPQgkpeatdiqqvpV 108 house mouse
XP_003474708  33 SGSSDNSYDFLSAEEKECLLFLEETIGSL-DAEADSVLSTDESEPATTP---RSFRAPPF-TPLAPHgnpeetvtqqrpE 107
XP_001372705  33 SGFSDSSYDFLSAEEKECLLFLEETIGSLeDKEADSGLSTDESQPAT-P---QGPR-----TQPVLQgyqeerltqgrpE 103
XP_008113876  36 SEMNDSGYDYLSVEEKECLMFLEETLDSL-DAEADSGLSTDGAETS------KHPRTWP--TRDVPKgldren--linhr 104
XP_003438845  15 SGYSEDSMDHLSAEERACLTYLEETIEAL-ETQEDSGVSNDESHHESLTekaDQMRVNDI-STLMPNgsk-------sdq 85 
XP_012662086  33 SGSSDSSYDFLSAEEKECLLFLEETIGAL-DTEADSGLSTDESESATTP---QGSLTLPI-TQLTPWgnpegttthqepE 107 small-eared galago
XP_017203315  23 dsmSDSSYDFLSAEEKACLLFLEETIGSL-DTEGDSGLSTDESELVPTP---RGFRAPPK-TQPAPKgnpkeaiaeqrpE 97  rabbit
XP_023103630 108 PRTGTQSSSPHLPEPEGLGLRSGSHSLPRNIHIGRKRNPREST----TQTNSHIPG-EPEGLVPEPKREQAGQSG--EPS 180
ELW47758     355 PRKVSGSSSFHPSEPQRLGLRSGSYSLPRSIHIGRSQNLRKST----TQTNGHGPG-ESVGPVAKPEKEQVGQSS--EPS 427
EGW00962      84 PKRVPQSSG--PPESPSLGLRSGSYSLPRNLHLGRSQNLRESA----TQTNSHGSQ-TPGVYLAEPEKAQTSQTT--KPF 154
Q8BI29       109 PKRVAQPSC--PPESHSLGLRAGSYSLPRNLHLGRSQNLRESA----TQANSPVSE-ASEVFLEEPEKGQTSQGAkaKTI 181 house mouse
XP_003474708 108 PKRVNETSSSSPPEAQGLGLRSGSYSLPRNIHIGGNQSLRQST----TQTNSHFPArESEGPLAEPTKAEASQSS--EPH 181
XP_001372705 104 QKRDIQSTTTRL--RQDLSVKSGSHSLPRNIHINRDQSLREGSacrpSQSEGHIPR----GLVLAPLGHRTSRVV----- 172
XP_008113876 105 KNEINGIKSVSDPVDI---PSPGHRSLPRNII-------VKSVpktaNISLVEATSfKTENQKDLPQIYLTSWGSpkNET 174
XP_003438845  86 KSFLSDEVPTAPPASTALATE-GKTQL--NQI---SEPQDSPL----IPESSTHTKiLSSAMQTEMSSSATNEDA--DPE 153
XP_012662086 108 PRRVTQSHSSRPPEPQGLGLRSGSYSLPRNIHIGQNQNLRKST----TQANSHIPG-DAEELVAEPE--QVNQRS--VPS 178 small-eared galago
XP_017203315  98 PRTVTQASSFHPPEPQGLGLRSGSYSLPRNIHIGRNQNLGEST----SQTNSHAPG-EPAGL---PAVKQPGSRLngEPR 169 rabbit
XP_023103630 181 ------QAPAGPPTP-----ALGLDTVPIPPPEAFQDSQPEQ----------------------------RGEGGLGVpR 221
ELW47758     428 ------QPPARHREV-----ALDLDVAVIPPPEAFRDTQPAQ----------------------------PGENSLPK-G 467
EGW00962     155 ------QSPAPSQET-----TLDLNTVLIPPPEAFQDIRPKQ----------------------------SREESPLK-E 194
Q8BI29       182 ------QPPAPSQKG-----TLDLSTVLIPPPEAFQDIRPKE----------------------------SGEESPPK-K 221 house mouse
XP_003474708 182 ------KAPASPRRA-----SLHLDTELIPPPKAFQDGWLQQ----------------------------GGEDSLLK-G 221
XP_001372705 173 -------PPVSPGTP-------ELEEVLLPPPEAFRDTYQEQdtrrsqf---------------lkektrSGQDSLPL-- 221
XP_008113876 175 ldisndQFKTTTQSK-----VSDLESVVILPPEPFQDHKQSYskrdqepqflnkvsqtveivlpphfevrKSFDHVERyE 249
XP_003438845 154 ------SVKSTIVCPgsstnTSETDLSVIPPPLNFRDEPD---------------------------------------S 188
XP_012662086 179 ------QAPASPQGA-----APDLDVVLIPPPEAFRDTQPEQ----------------------------CREDSLPK-G 218 small-eared galago
XP_017203315 170 ------PGPAGPREA-----APDLDVAPIPPPEAFRDAQPEQ----------------------------REEDHLPK-R 209 rabbit
XP_023103630 222 PGLQSHTPRlhs---slSPQERKETPSAAMSQKA--SE--KGSTGGPGQPQPPPAAssqsaRAGDAPIPSGGDPSARPAP 294
ELW47758     468 LGEQKHPPP--------NSQQRKETSSETMSHKA--NE--KGITGGPSQPQPPPAT-----STENAPRPLSGEPSAQLPP 530
EGW00962     195 LGEKRYTPQahs---lvSLQKKE--PSETMSHKA--TE--KGWTEGPQQPQLPPTQssqntRAEEALLPSGVKPNTQQAP 265
Q8BI29       222 PGEQTHTPQvhslerspHSQKKVEMSSETVSHKA--TE--KGWTEGLQQPQQPPAQssqptKAEELSLPSGVKPSIQQTP 297 house mouse
XP_003474708 222 PGEQSHAPPk---------------rVEVMSLTD--SK--KGTPEGPGQPQPTPTRlsqdaRAEDTSLLLGDDTNGRLAP 282
XP_001372705 222 -------PRaa-----pVTQEKKEVFLETMSQGT--KEvlEGLPRQPGLPLPLsse---nlGSENLTIPLGDEKSPKFAP 284
XP_008113876 250 ATQQEPSPEk------aDLAREKEVTLKSVSPKG--NKksfeqm-----------lgvqenDQKPTQEETSLDFSPKQGP 310
XP_003438845 189 PSQPVKVKDltpsvgisRKKPGPTFDLEQIRQRAsvKKnlTSPVTKEPQIKPPPDEslsllTSSQIVAPSSPESAEPKSP 268
XP_012662086 219 PGQQSHTLQphm---pvSSQKREQISSETMSQKA--KE--KESEGNARRPQPQPAMlsqnaRAEDTPLPSGEDPNARLGP 291 small-eared galago
XP_017203315 210 PGEQSQAPHa---------rKTEETSSEAMSHKA--NE--RGSVGHP------------------QPLASASDPGAQPAS 258 rabbit
XP_023103630 295 FT-APKPRKLPPNIVLKSSRS---SLHSEPHHWL------SRHSEATAGDSGL-----ASSSLQEQKKARREALEKLGLP 359
ELW47758     531 LT-APKPRKLPPNIVLKSSRS---SFHSDPQSWL------VRHTEATPGDSGL-----VSSSLQEQRKARREALEKLGLP 595
EGW00962     266 LT-ASKARRLPPNIVLKSSRS---SFHSHPQNWL------SNHTEAT--DSGP-----VPSSLQEQKKARREALEKLGLP 328
Q8BI29       298 LT-ASKARKLPPNIVLKSSRS---SFHSHPQNWL------SNHTEAT--DSGP-----V-SSLQEQRKARREALEKLGLP 359 house mouse
XP_003474708 283 LT-APKPRKLPPNIVLKSSRS---SFHSEPQSWL------SRHAEA--GDASA-----ASSSLQVQRKARREALKKLGLP 345
XP_001372705 285 PT-APKSRKLPPNIILKTSRS---NFPSDPQNRF------SHRSQATSRDSTPdhassASSGLQEQRRARREALEKLGLP 354
XP_008113876 311 PT-APKPRKLPPNIILKTSRSnvvSYNIDPNHKLkvlspaNGRPRAATGDFSMe---kVHSLQKEQERARREALEKLGLP 386
XP_003438845 269 PVvAPKPKKLPPNIILKSHKM-------TNSDGN------SVHPALNSSEQRP---------FLDPHKVRMEALRKLGLL 326
XP_012662086 292 IT-APKPRKLPPNIVLKSSRR---SFHSDPQNWL------SRHTEAASGDSSV-----VSSSVQEQRKARREALEKLGLP 356 small-eared galago
XP_017203315 259 LA-APKPRKLPPNIVLKSSRS---SFHSQPQNWL------SRHTEAASGESGL-----GPSSLQEQRKARREALEKLGLP 323 rabbit
XP_023103630 360 QDQ-DEPGPHLSKRTSSTRFKEthaqa--sfqaLAPAPAPAQPTRPaqGT--------------AAAPaggkapap-apt 421
ELW47758     596 QDQ-DEPGLHLSKPTTSIRLKD-----------PVQAPPQASAAAP--TG--------------KAPTltpa-------- 639
EGW00962     329 QDQ-DDPSLLVNKHTSTLKVKEaqa------qsPSQALATVQQASPalAP--------------EAASa----------- 376
Q8BI29       360 QDQ-DDPSLLVNKHTSTLKVREaqp------qtPSQARAPARPASPalVS--------------GTASa----------- 407 house mouse
XP_003474708 346 QDQ-EEPSLSLSHSASFIRHKKtqd------qgPATFPAPAQPAALpaTG--------------QAPA------------ 392
XP_001372705 355 QDQsDEPSLQRAKSGSILRSRQsppqastsapaPVRAPAPAPAPAPvrAP--------------APAPapa--------- 411
XP_008113876 387 LDNeKDPEDHVAKTSAYSKSREm--------------------------------------------------------- 409
XP_003438845 327 KSS-EEESIPNQSSKLPLKARVsw-------aaPSSSSPPISPAAPn--------------------------------- 365
XP_012662086 357 QDQ-EEPGLHLSKPRSSIRFKEprdq----rpsPAPAPAPAQPA----GAaqisaavpaagkppGPARgp---------- 417 small-eared galago
XP_017203315 324 QDQ-EAPGLHLSKPASSFRLREpraq----gpaPGAAPGPAQPAAPvqVS--------------AAAGkapapapvpals 384 rabbit
XP_023103630 422 rgpsPAKPPAPTPAQGSSPDKGLIPAREPTAGKV-PAAKSMPIPI------PKAPGA----GGPLAQAKADSGL---TLP 487
ELW47758     640 lgvsPKKTPALTVAQGSSSGKVLLPTQEPSPGKV-AAAKSTPIPI------PKAPRV----NSPLSRPQPDTGL---TLQ 705
EGW00962     377 ---aGKTSPV---KAVTSSGKSWIHAQETPPGKV-AAAKSMPIPV------PKTSKA----NSSLTQPKPDPLL---TLQ 436
Q8BI29       408 ---aGKVSPKKAVAPMDSLSKGWIPTQETPPGKV-AEAKSMPIPI------PKTLKE----NSSRTQPKPDPRL---TLQ 470 house mouse
XP_003474708 393 ----PAPAPAPAPAPTSSPGKVCTTAQEAPPGPA-TAHKSMPIAI------PKTSKA----NSPPTKPKPDSGL---TLQ 454
XP_001372705 412 --pvRAPAPAPAPAPVRAPAPVSQVLASGPSARA-QGPPSTPIPI------PKPTRVssvdNSPPAQSSPGSRL---ALK 479
XP_008113876 410 ---------------sQIYSRENVQTENITHNRN-PDQKHAQIDE------EENYAG----------------------- 444
XP_003438845 366 ---------ePPSSQSYNLPPASVTVQPLNPGAIlPSNTSTALTVldpdilPAPADF----SDPIELSPSENHPsavKDA 432
XP_012662086 418 ---sPKQPPAPTLAQGSSPSKVLIPAQETSHGNV-TSAKSMPISI------PKAPRA----NSPLTQ--PDSGL---TLQ 478 small-eared galago
XP_017203315 385 rgpvPAKAPTPAPAQGSSPSKAWTPAQETPPGKV-AAAKSMPIPI------PKASRA----NSPLTQPKPDSGL---TLQ 450 rabbit
XP_023103630 488 ESN-VPGL-------RQMSFKSNTLERSGVGLSSYLSAE--KDPSPQTSTSLGKGSFLDKMSPSVLRNSRPRPASLGTGK 557
ELW47758     706 EGN-VPGL-------RQMNFKSNTLERSGVGLSSYLSAE--KDPRPKTSTSLGKGSFLDKISPSVLRNSRPRPASLGTGK 775
EGW00962     437 ESS-IPGL-------RQINFKSNTLERSGVGLSSYLLAAe-EDTKCQTSTSLGKSPTLDKVSPSVLRNSRPRPASLGMAK 507
Q8BI29       471 ESS-IPGL-------RQMNFKSNTLERSGVGLSSYLSAAekKDPSCQTSTSLGKSPFLDKVSPSAFRNSRPRPASLGMGK 542 house mouse
XP_003474708 455 ESS-IRGL-------KQMNFKFNTLERSGVGLSSYLSAE--KDPSPKTSTSLGKDSVLEKASPSVLRNSRPRPASLGTGR 524
XP_001372705 480 EGS-IPGL-------RQMNFKSNTLERSGVGLSSYLLAA--KDNAPQTSTSLGKVPILEKTSPNVLRNTRPRPASLGGGK 549
XP_008113876 445 VNN-IPGT-------KQTIFKSNTLERSGVGLSSYICPGt-EDQNIKNSSSSGKMSFFEKITSNFIRNTRPRPASLGMGK 515
XP_003438845 433 TSFtYPGLvkqltppKG---KSASLGRSEVGVSRYTAGQdfSEASQGTSI---------NQNLNQLRNHRPRPASLGSRK 500
XP_012662086 479 KSS-IPGL-------RQMNFKSNTLERSGVGLSSYLSAE--KDTSPKTSTSLEKASFLDKVSPSILRNSRPRPASLGTGK 548 small-eared galago
XP_017203315 451 DSS-IPGL-------RQMNFKSNTLERSGVGLSSYLSAE--KDPSPQTSTSLGKGSLMDKISPSVLRNSRPRPASLGTGR 520 rabbit
XP_023103630 558 DFAGIQVGKLA---DLEQEQSTKRLS------FQGQSRDKLPRPPCVSVKISPKGVPDEHRREALRKLGLLKE 621
ELW47758     776 DFAGIQVGKLA---DLEQERSSKHLS------YQGQSRDKLPRPPCVSVKISPKGVPDEHRREALKKLGLLKE 839
EGW00962     508 DFTEIQGGKLV---GLGQGQHSQQLS------FKGQSHDKLPRPACVSVKITPKGIPDGHRREALKKLGLLKE 571
Q8BI29       543 DFAGIQGGKLV---GLEQDQCSQQPS------FKGQSYDKLPRPPCISVKISPKGIPDGHRREALKKLGLLKE 606 house mouse
XP_003474708 525 DFAGIQVGRLA---DLEQGQNSKHLS------YQGQSRDKLPRPLCVSVKISPKGVPDEHRREALRKLGLLKD 588
XP_001372705 550 DFASIQVGKLA---DLEQERNSQRFS------YPGQSRDKLPRPACVSVKITPKGIPDEHRREALKKLGLLKE 613
XP_008113876 516 DFVDLKENKAH---NDELEKSDKRRS------YPYQPASMLPRPPCTSVKFTPKGVAEEHRREALKKLGLLKE 579
XP_003438845 501 EFSSAQAEGLEagpSITKEPASQKALpahtpfHHSRDTQKLPRSQGISVLICPRSENEEDRRGALKKLGLLRD 573
XP_012662086 549 DFAGIQVGKLA---DLEQEQSSKRLS------YQGQSRDKLPRPLCVSVKISPKGVPGEHRREALKKLGLLKE 612 small-eared galago
XP_017203315 521 DFAGIQVGKLA---DLEQEQSARHLS------YQGQSRDKLPRPPCISVKISPKGLQDEHRREALKKLGLLKE 584 rabbit
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