Conserved Protein Domain Family
Perilipin

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pfam03036: Perilipin 
Perilipin family
The perilipin family includes lipid droplet-associated protein (perilipin), adipose differentiation-related protein (adipophilin) and TIP47, also known as perilin-3, altogether form the PAT family of proteins. They predominantly localize to the surface of intracellular neutral lipid droplets. Perilipin is a modulator of adipocyte lipid metabolism and adipophilinis and are involved in the development and maintenance of adipose tissue. This family appears to share some similarity with pfam08618.
Statistics
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PSSM-Id: 460784
Aligned: 35 rows
Threshold Bit Score: 305.366
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006640158  21 GSREQQS---VVTRVASLPLVSSACGALSSAYSSAKESAPYLRGVMDAAESGARTLGAAAASGSRPLLDRLEPQLTVVNE 97 
9_pfamImport   1 TFITNDN---ALNRVASLPIVASTWNAMQSYYATVKKTYPNVSPYLEAAENLTVSAANLALETSRPVVDRFG---NTVNS 74 
XP_012397830  13 NHPEQEN---VLQRVFQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFSAANE 89 
Q8CGN5        13 DLPEQEN---VLQRVLQLPVVSGTCECFQKTYNSTKEAHPLVASVCNAYEKGVQGASNLAAWSMEPVVRRLSTQFTAANE 89  house mouse
XP_008120454  16 TRDDRLC---VIKKVAELPLVSSTYEMVSATYTSAKKSHPAIQAVCDMAEVGVKAIATTAASGAQPFLDKLEPQIAAVDT 92 
XP_012397482  17 EQQPQAQdrdLVSRVINLPLVSTTFARASAAYSSVKENHPYLNSLCGLAERSLQGLTTRAAQGAQPLLNLLEPQITSVNK 96 
M0R7Z9        30 GELDQHN---VVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVND 106 Norway rat
NP_001107246  15 SEQDQQS---AVQRVAALPLIRATCTAVSEAYSAAKDRHPLLGSACRLAEHCVCDLTTRALDHAQPLLSHLQPQLATVND 91  sheep
XP_023604391  13 DCPEQEN---VLQRVLQLPVVSGTCECVQKTYTSTKEAHPLVASVCNAYEKGVQGASSLAAWSMEPVVRRLSTQFTAANE 89  little brown bat
XP_003788855  13 DFPEQES---VLQRVLQLPVVSGTCECVQKTYTSTKEVHPLVASMCNAYERGVQGASSFAAWSMEPVVRRLSTQFTAANE 89  small-eared galago
XP_006640158  98 YACKGLDRLEEKLPILQQPTEKVVADTRELVSsvqqsvsQSVSGARQAVTGAVTGAVGVAKGAVQGSVDVTRAAVSGGVS 177
9_pfamImport  75 YANKGLDTLESKVPIITKEPEEVLFQF------------DVISHLCNKIVVYINAKVSI--GSCLNECERHVLHCYKSLN 140
XP_012397830  90 LACRGLDHLEEKIPALQYPPEKIASELKDTIS-------TRIRSARNSFSVPIASTSDKILGAALAGAELAWGMAQDTAD 162
Q8CGN5        90 LACRGLDHLEEKIPALQYPPEKIASELKGTIS-------TRLRSARNSISVPIASTSDKVLGATLAGCELALGMAKETAE 162 house mouse
XP_008120454  93 LACKSLDVLQERFPVVQQTVEKVVSNAKGL------------------LTESLAPVYTKVTEAAQESIEMASSTVRNGVH 154
XP_012397482  97 YACKGLDKLEEKLPFLRQPSQEVVTSAKDA------------------VTSSVTGVVGLAQKGRRWSVDLTRSVVTSGVD 158
M0R7Z9       107 LACRGLDKLEEKLPFLQQPSDTVVTSAKDA------------------VAKSVTGVVDLAQRGRRWSGELRRSVS----- 163 Norway rat
NP_001107246  92 LACRGLDKLEEKLPFLQQPSETVVTSAKGV------------------VASSVTGMVGLARQGRRWSVELKRS------- 146 sheep
XP_023604391  90 LACRGLDHLEEKIPALQYPPEKIASELKGTIS-------TRLRSARNSISVPITSTSDKVLGAALTSCELALGVAKDTVE 162 little brown bat
XP_003788855  90 LACRGLDHLEEKIPALQYPPEKIASDLKDTIS-------TRLRSARNSISVPITSTSDRVLGAALSSCELAWEVAKGTAE 162 small-eared galago
XP_006640158 178 -------------TMMGSRVGQMLSSGVDLALSRSEEWVEQLLPLSHRELAALSEP--VSGGEAGP---PAAQQSYFVRL 239
9_pfamImport 141 qieflynyfkwmyNITKSTATSLINNKVEGALEVTERYVEYYLPKDEDEEEDEEGE--ENDPEA------KKQPS--DRI 210
XP_012397830 163 -------------YASSTRVGQLAAGGADLALSNVEKVVNYLMPAPKENP---APV--LEHPSPSQvqqKLPKPSFLQRI 224
Q8CGN5       163 -------------YAANTRVGRLASGGADLALGSIEKVVEFLLPPDKE-----SAP--SSGRQRTQk-aPKAKPSLVRRV 221 house mouse
XP_008120454 155 -------------TVMETSMGQMVSNGVSEMINKSDIWIDKYLPITDSELAALAASaaLEVSDMPPliiQTKDQKYYVRL 221
XP_012397482 159 -------------TVMGTRMGQMVTNGVDVMLDKSEELMDHFLPMTDEELDELAAA--AEGGTLAPg-dDQHETSYFVRL 222
M0R7Z9       164 -------------QAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATE--SQGPEVGSveeQRQKQGYFVRL 228 Norway rat
NP_001107246 147 -----------------------VSHAMDVVLEKSEELVDHFLPMTEEELAALAAE--AEGPEVGSveeQRKHQGYFVRL 201 sheep
XP_023604391 163 -------------YAAKTRVGRLASGGAELAVGGMEKVVEFLIPPAKDE----SAP--VPGRQQAQk-pPKTNRSLMSRV 222 little brown bat
XP_003788855 163 -------------YATNTRVGRLASGGADLALGGIEKVVEFLLPPAEEDS----AP--AVGCQPAQk-pSKAKLSLMSRV 222 small-eared galago
XP_006640158 240 GTLSAKVRQRALELSLGRARRAHESALSTLASLTTTLDLIERTKAALSsatDRLGGAQEQLLQHWAEWK----EGQP--G 313
9_pfamImport 211 REISNKVRQRSYKRAMRKLHGVQTRSKEALSKLSFTVDLIQYAQSGLNstsAGIMDSANRANESVQNGM----NVAK--- 283
XP_012397830 225 GTLTNNISQHTFHTTIQTLRWG----HALAKWIPGVAPLSSMAQWGVSaalEVVSRPRSTSRGNWQYNQ------AQdeE 294
Q8CGN5       222 STLANTLSRHTMQTTAWALKQG----HSLAMWIPGVAPLSSLAQWGASaamQVVSRRQSEVRVPWLHNL----AASQdeS 293 house mouse
XP_008120454 222 GSLSAKLRSRAYHHSLEKVQRVKQTFDMALFHLEQFMHLLRFTKQTWE---YKIQQGQEKLRQMWLEWI----RGQP--G 292
XP_012397482 223 GSLSSRLRQRAYQHSLGKLRQKKHQAQESFSQLHDTLEMIHYMKHGSN---HNFQGGEGRLQKLWQEWS----------- 288
M0R7Z9       229 GSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRAS---PTPTFHHPKVQELCGDWS-------PclE 298 Norway rat
NP_001107246 202 GSLSTRLRHLAYEHSLGKLRQKKHHAQDTLAQLQETLELIHRMQCGVT---PITPARPGKVHELWEDWS-----QRPleN 273 sheep
XP_023604391 223 GNLANTVSQHTFQTTKQVLKQG----HALAMWIPGVAPLSSLAQWGASaasQVVIRRPSEVRVPWLHNLaaaaAAAReaD 298 little brown bat
XP_003788855 223 GALTHTLSQHTVQTTAWALKQG----HALAMWIPGVAPLSGLAQWGVSvamQVVSQQKNEVQAPWLHKL----TTAQe-D 293 small-eared galago
XP_006640158 314 GKEAEedkgqmqSDDHVEL--EGRA-LSMARGLSAQLRAACSG------VVSTAQGLPV--SVQEQVAA-ALRAAEELQA 381
9_pfamImport 284 -SNLQvv----tDSINKQV--EENV-LNRARILSRQLSDTCQW------SIRYIQNSPQlqPLLKKANQ-VKDASDDLYQ 348
XP_012397830 295 EDEEE-------EEEEEEE--EDEE-NLEMRKEENKLNETMPSnq--slLGSVVHTLQS--AYLTTVST-VKWAPFAIWN 359
Q8CGN5       294 HDDQT-------DTEGEET--DDEEeEEESEAEENVLREVTALpnprglLGGVVHTVQN--TLRNTISA-VTWAPAAVLG 361 house mouse
XP_008120454 293 QSAIS-------EPSQAEM--ESQA-LQVSQTITRQMQANCLK------LLTDMEGLPD--ALKEKVQE-AYSSLEEVQS 353
XP_012397482 289 -HQDK-------ESYQSQV--ESQT-LDLSRDLTQELQATCET------LAASVQGLPP--AVQAKVLE-VQQSVEELHR 348
M0R7Z9       299 N-----------GYRHSQV--ELET-LALSRSLTLELQSAVDA------LAGCVRGLPP--SAQAKVAE-VQRSVDALQA 355 Norway rat
NP_001107246 274 G-----------RRRHSQA--ELET-LVLSRNLMRELQSTVDA------LETSVRGLPp---SAQEKVAeVRRSVDALQA 330 sheep
XP_023604391 299 HDDQT-------DSEGDEAkeKEKEkEDSDSETEEQLSEAADLarpqglLGSAVHTLQK--AVQGTISA-MLWVPTTVLG 368 little brown bat
XP_003788855 294 HDDQT-------DTEEEET--EEEE----LKAEENKFSEVALPspr-glLGSVAHTLQK--TLQSTISA-VTWAPVAVLG 356 small-eared galago
XP_006640158 382 SLGGATSFSNP---LLAQSRAR--MAQVRQSVDATMEYLLNNTPLNWLVG-----PFSPQI 432
9_pfamImport 349 MFANKTSLSQLpttLMVSARPK--IQFVEESLLQILQKMSDQPPIAWLTPrvdfdPFAELS 407
XP_012397830 360 NTAGRLLHLTSgqeTFAKGRAMslSDALKGVTDNVVDTVVHYVPLPRLS------LMEPES 414
Q8CGN5       362 TVGRILHLTPAqavSSTKGRAMslSDALKGVTDNVVDTVVHYVPLPRLS------LMEPES 416 house mouse
XP_008120454 354 ALSNAQTFQDIpsgILSQSPEK--IGKAQHAVHEVMEYVTRTPPVTWVAG-----PLSAGV 407
XP_012397482 349 AFSTARSFHDLppaVLAKGRGH--MMQAHTTVDELLEFVIQSIPLPWLVG-----PFSPLI 402
M0R7Z9       356 TFADAHCLGDVaptALAEGQDS--VAQAHACVDEFLDLVLRAMPLAWLVG-----PFAPIL 409 Norway rat
NP_001107246 331 AFADARRFGDLpaaVLAEGRGS--MARAHACVDELLELVVQAMPLPWLVG-----PFAPIL 384 sheep
XP_023604391 369 TAGRMLHLTSApaaTSTKSRAMslSDALKGVTDNVVDTVVHYVPLPRLS------LMEPES 423 little brown bat
XP_003788855 357 TAGRVLHLTPAravPSTKGRAMslSDALKGVADNVVDKVVHYVPLPRLS------LMEPES 411 small-eared galago
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