Conserved Protein Domain Family
DUF2075

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pfam09848: DUF2075 
Schlafen group 3, DNA/RNA helicase domain
This domain is found in at the C terminus of group 3 Schlafen proteins from mammals, and represents the DNA/RNA helicase domain. Schlafen proteins are involved in the control of cell proliferation, induction of immune responses, and in the regulation of viral replication. These proteins inhibit DNA replication and promote cell death in response to DNA damage. They play a role in genome surveillance to kill cells with defective replication. This domain is also found in various uncharacterized prokaryotic proteins fused to a DNA helicase, GIY-YIG or PD-(D/E)XK catalytic domain or HsdR-N(terminal) domain, which are similar to AAA DNA helicase, Type III restriction enzyme ATPase, RecD and RuvB helicase.
Statistics
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PSSM-Id: 430875
Aligned: 38 rows
Threshold Bit Score: 258.364
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAF39755         236 SRLIFVQGVAGTGKTVLLSHLFYRIatemdingrindedDEdiletdsslkiskEDRRKAYILVNHNQQMHVYNQIASKL 315
Q6MJU2           233 KTICLVTGVPGAGKTLVGLDLATSWn------------nPV-------------ANQHAVLLSGNGPLVEILQEALAKDE 287 Bdellovibri...
Q12HM1           237 KAICFVTGVPGAGKTLVGLNIATKHi------------dKD-------------SELYSVFLSGNGPLVDILREALARDR 291 Polaromonas...
Q21ED4           234 KSIVFVTGVPGAGKTLVGLNIATAHi------------dQD-------------DELYSVFLSGNGPLVAILQEALARDK 288 Saccharopha...
Q5FQ65           242 KVIVFVSGIPGAGKTLCGLKAAFAD--------------GD-------------DGTGATFLTGNPTLVSVLREALTRDT 294 Gluconobact...
WP_012040429     238 RVVVFVTGIPGAGKTLCGLNTVFR------------------------------SAAPAAFLTGNLPLVHVLREALARDA 287 Acidiphiliu...
jgi:Veis_1178    245 RCVCFVTGVPGAGKTLTGLNVVHDPsl-----------rVE-------------GGPSGIFLSGNGPLVKVVREALVLSQ 300
mpitm:STAUR_1260 250 rTVCFVTGVPGAGKTLAGLAAVHDPsv-----------sDG-------------TEGQAAFMSGNGPLVRILREAIVRNR 305
jgi:Mboo_0351    238 LHLALVTGVPGAGKTLVGIQLVYENhl----------egSD-------------LQNTAVFLSGNGPLVKVLQHAL---- 290
WP_012064100     228 RVLILATGVPGAGKTLLGLKFVYECf------------kDD-------------SKKQSIFLSGNGPLVDVLQHAL---- 278 Alkaliphilu...
BAF39755         316 g-------lQKHFGEVALKPSQFINRFSekttsnraiadKPRGKADVVLVDEAHLLLT-----------QGDQ--GYSGK 375
Q6MJU2           288 anrs-kassPVKLSAARAKAKSFIQNIHhfrde--glrtDAPPPEKVVIFDEAQRAWNktqttkfmktkKGVAdfDHSEP 364 Bdellovibri...
Q12HM1           292 vsrevatgrKMKKGTAVSEVKAFIQNVHhfrdd-clqdmARPPVEHVAIFDEAQRAWNleqtaafmsrkKGRAdfKLSEP 370 Polaromonas...
Q21ED4           289 varakqngeKIKIGAARSEVKAFIQNVHhfrdd-gladlNKAPAEHVVIFDEAQRAWNkqqtvdfmrmkKGQLnfDQSEP 367 Saccharopha...
Q5FQ65           295 vs------rGQKRLLVEQRMESTIQSLTkfrdh-yvgrpAECPPEHVMVIDEAQRCWKqaqav--rksaSRHVklTESEP 365 Gluconobact...
WP_012040429     288 kg------pGMSLRAANHRLDSAIQPLLgflrd--nvprAAAPHERVIVFDEAQRAWDaa-------fgQRKFqlDDSEA 352 Acidiphiliu...
jgi:Veis_1178    301 qr------aGRRRQDSAHEVSTFIQNVHqflry-hrehpAALPHEHVVVFDEAQRAWDre-------qmQRKQgvDRSEA 366
mpitm:STAUR_1260 306 lq------rGGRRGELERQSELLIQNVHefieeygvqrrDGFPHEHVIVFDEAQRAWHadk------vrTRHKevQKSEP 373
jgi:Mboo_0351    291 ------------------KYKIFVQDVHgflke-yggetAKIPHEHIWVYDEAQRAWDae-------rvSEKRghATSEP 344
WP_012064100     279 ------------------DSKVFVQPLRhyvkh-ygiqkREVPKEHIIVFDEAQRAWDle-------hvRKKHniDLSEP 332 Alkaliphilu...
BAF39755         376 NMLHDLLRR-AK--VVIAVFDPNQILQTSQRWSEED-----QDMLFPQQAESDvqkTaagysgqlerfvp---lnmwgdh 444
Q6MJU2           365 EYLIKLMDRhADwaVIICLVGGGQEINTGE-AGISEwl-daIHNKFPHWQVCLpstTssadipniekfvq----afssrh 438 Bdellovibri...
Q12HM1           371 EFLISCLDRhQDwaVVVCLVGGGQEINTGE-AGIGEwi-qsLQRSFPEWRIHIspqLhdeeygagavmre---iadrpgv 445 Polaromonas...
Q21ED4           368 EFLISCMDRhKDwaVVICLVGGGQEINKGE-AGIHGws-haIKESFPKWKIYAsdqLkdseyggaatise---lrsiqgs 442 Saccharopha...
Q5FQ65           366 AHLLDIMGRhDGfaAILCLIGHGQEINDGE-GGLACwgealLSH--PAWRVEAapdVigtgdlthlpt--------tlea 434 Gluconobact...
WP_012040429     353 GLFLDIMARhEGgaAIVALVGNGQEINTGE-AGLASwgealARR--PGWRIVGpegVighpdparrlad-----aapagm 424 Acidiphiliu...
jgi:Veis_1178    367 AELFDVMDRlDGwaVIIALVGGGQEIFLGE-AGLEEwgravAVR--PDWRVVAspeVvsggasvsghrlftdgvpsgief 443
mpitm:STAUR_1260 374 AMVLESMARvPNwcVVIALVGGGQEIHSGE-AGLEEwg-raLQESPIPWRVVVspeVlsggtavaqrflfdaapsphlhv 451
jgi:Mboo_0351    345 EDFLRIAERmNSwgLMVALIGEGQEIHLGEESGLPQwn-daLAKMQKPWIVHCpkkIagtftaak-------------kl 410
WP_012064100     333 DLMIRITDRiPSwaALLGLIGEGQEIHNGEEAGIKQwk-eaVKKSKMKWKVICpskIahifedvv-------------ev 398 Alkaliphilu...
BAF39755         445 yllsriCLHRQFRIAADDATIRWIDDFADGKRIGRIPQdigekdrktgeyvREPFEIRVFDSPVGLFKAIKEKaylkaSG 524
Q6MJU2           439 hvdknlHLTASVRSFRSERVSDFMSALLDKDIDKAKALys---------eiKEKYPIKLTRSLEEAKLWLKEK-----SR 504 Bdellovibri...
Q12HM1           446 hlnehlHLAVSMRSFRAEHVSALVKHLLDRDADAARAMla---------rvQDRYPIVVTRSLQKAKSWLKQQ-----AR 511 Polaromonas...
Q21ED4           443 nflpelHLQTSMRSFRSEKVSLFVKQLLDMELAEAQQTys---------qlFQNYPITLTRNLDSARKWLKSQ-----AR 508 Saccharopha...
Q5FQ65           435 grqrflHLGVAIRSLREETAPRWVNAVLNGDVETAQRLa-----------gQTDLPFRLTRSLDDLRAGLRHR-----SR 498 Gluconobact...
WP_012040429     425 eidpalHLDVSVRQVRSAAAAAWIDAVLDGRAEMAAGIas----------aAGGVPFRITRSLDAMRAALRGA-----SR 489 Acidiphiliu...
jgi:Veis_1178    444 rpeplaHLSVGVRSFRAQRLAEWVDAVLLLDTEHARSLvp----------dRREFPLHFTRDLEVAKAWLRAR-----SE 508
mpitm:STAUR_1260 452 vpapsmHLSVSVRSPRALHIAEWVNAVLALDEKRARDAiq----------eISGFRVALTRDLSIARAWLRDS-----SR 516
jgi:Mboo_0351    411 atsdvlDLSVSLRSHLAEDVAQWISALLEGDLIHAKTLses--------vtSQGFDVYLTQDINVATNYVKER-----YK 477
WP_012064100     399 vaidklDLNTTLRSHLSEDVTTWANKLLRGSILEAKELslk--------inLEGFNMYVTRDLDKAKRYCQKR-----YE 465 Alkaliphilu...
BAF39755         525 VDG--CglSRVVATYDWEYKggki-ndsSPDGLWNVEMhrdaqgvwrmgaapgmqrgydafnpdgradyfchPWNYEIKv 601
Q6MJU2           505 GNE--R--YGILASSGAGRLkahgldvkSRIEPV--------------------------------------NWFLNDK- 541 Bdellovibri...
Q12HM1           512 GSE--R--FGMVVSSQAQRLrphaidvrSPMDPI--------------------------------------HWFLDGK- 548 Polaromonas...
Q21ED4           509 GSE--R--YGIVVSSQAERLrplgvhvkAPVNPV--------------------------------------NWFLDGK- 545 Saccharopha...
Q5FQ65           499 LTY--R--CGLVASSKAKRLraeglgceVPHMDDKAVS----------------------------------QWFLNRW- 539 Gluconobact...
WP_012040429     490 GTR--R--AGLVCSAGAKRLraeglsadFPHMDRQAVA----------------------------------SWFLNAW- 530 Acidiphiliu...
jgi:Veis_1178    509 PGCgqR--AGLIATSEDQRLrayglersSAFRLDYSFE----------------------------------KWFLMPP- 551
mpitm:STAUR_1260 517 DER--R--PGLLASSGSLRHraygleltPAFLDAYPVE----------------------------------NWFLDDA- 557
jgi:Mboo_0351    478 DQEdkR--YGLLASSKAKNLptwgihneYNYTKNMREG----------------------------------PWYTDPP- 520
WP_012064100     466 GNKekR--YGLLASSKAKILpeyqvdnsYDTTKQLEVG----------------------------------PWYNYGL- 508 Alkaliphilu...
BAF39755         602 gdkglsLDAVWAESPHTLNEVGSTFSIQGFDLNYVGVIIGPSVTYR------EGKIVFNEKASCNKRAVSKRngsISYAQ 675
Q6MJU2           542 ---------KDVRSSFFMEDVATEFHVQGLELDWTCVAWDIDFILSlk--keTKFRSFAGTKWNNIKSSTDQ-------- 602 Bdellovibri...
Q12HM1           549 ---------HDVRSSFYLEDVATEFHVQGLELDWACVVWDADFRYGhd--gwLHR-SFVGSKWNKINLPHRQ-------- 608 Polaromonas...
Q21ED4           546 ---------DDVRSSYYLEDVATEFHVQGLELDWTCLVWDADFRYTae--gwNNF-SFRGNKWQKINKSERK-------- 605 Saccharopha...
Q5FQ65           540 ------VPDKDIRASDALETCATEFAIQGLELDFVGLCWDGDLIRApsgdrwQPR-RFSGTKWANVSTAEAT-------- 604 Gluconobact...
WP_012040429     531 ---------PDVRASDALEAPATQYACQGLEIDNVGLCWGGDLIRPragdgwLAR-RFRGTRWEEIRHKEAA-------- 592 Acidiphiliu...
jgi:Veis_1178    552 ---------ADVRSSHALEVAASEFECQGLELDWVGLCWGGDLTPSasg-swEYR-KFRGSSWNQVRSDSER-------- 612
mpitm:STAUR_1260 558 ---------KDIRSSHCLEVAMTEFKCQGLELDFVGLCWGDDLTLQeshmgwDMR-AFQGNGWKQVKKEISR-------- 619
jgi:Mboo_0351    521 ---------SSFNSCCAFRDVATEFSCQGLELDFPIVCWGDDFVWDg--------------IWKSPPAKRSK---AKDPH 574
WP_012064100     509 ---------DNELSCCKMNKVATEFACQGLELDMPIVCWGEDMLW-------------QGTSWKKFEQGGAK---AKDPN 563 Alkaliphilu...
BAF39755         676 SNLRNELNVLLKRGVHGLYLFAVD 699
Q6MJU2           603 SYLKNKYRVLLTRARQGLVLFVPK 626 Bdellovibrio bacteriovorus
Q12HM1           609 TFLKNAYRVLLTRARQGMVIVVPE 632 Polaromonas sp. JS666
Q21ED4           606 MYQKNAYRVLLTRARQGMVIVVPE 629 Saccharophagus degradans 2-40
Q5FQ65           605 LWRLNTYRVLLTRARYETLIWVPQ 628 Gluconobacter oxydans
WP_012040429     593 SWQVNTYRVLLSRARYETVIFVPP 616 Acidiphilium cryptum
jgi:Veis_1178    613 TYVRNRYRVLLTRARLGMVIWIPP 636
mpitm:STAUR_1260 620 QYLLNKYRVLLTRAREGLVIWVPp 643
jgi:Mboo_0351    575 QLRVNSYRVVLTRGRDGFIVFVPP 598
WP_012064100     564 QLRLNSYRVLLTRGRDGFIVFVPD 587 Alkaliphilus metalliredigens
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