Conserved Protein Domain Family
Tmemb_161AB

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pfam10268: Tmemb_161AB 
Predicted transmembrane protein 161AB
Transmemb_161AB is a family of conserved proteins found from worms to humans. Members are putative transmembrane proteins but otherwise the function is not known.
Statistics
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PSSM-Id: 463037
Aligned: 24 rows
Threshold Bit Score: 455.56
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDS37277       2 AILGYQLVSTLIGISLLTKLSVHFSFTSVFVFGG-IYRSLLPTNREIL----GSAGLTKI------------KSKGrrsn 64 
XP_015785322   2 AILGIQLVVTMVMLSILHKFAIHYSFARWLLAHR-LIRYLQPTEQQIKrgvaALANERKAhqddknvkqsksKSNKqssf 80 
EFX86498      43 AVLGVQLIVTLLTISIMQKVTQRFSFGKWILCKTgLVYYLHPTDAELR----KLAGLPQPkpkpkp-kegdnKRGKh--- 114
XP_001942992   3 tLLGIQLIITMIAINLIHRLSHIYSFARWTLCSTgLVRYLHPTDKELR----QLSGLKKK------------DSKL---- 62 
EEB13811       2 ALLGTQLVLTLIMVSFIQKLGHHLSLGKWLLCSTgLIHYLHPTNEELR----SLAGIQKNn----------kNNKKn--- 64 
XP_006563429   2 ALLGAQLVITLIMVSVIQKLTPHFSLARWILCSTgLTRYLYPTDQQLR----ILAGVPKEks---------kKGK----- 63 
Q9VTF5         2 AVLGAQLVITLVMVSVIQKLSPHYSFAKWILCRTgLYRYLHPTDDELR----SRGGVPKEkp---------pKGGRn--- 65  fruit fly
2_pfamImport   1 AIFGFQLCFTLIMACFLQKLMPLFSFGRWLLCSGsLVRYKHPTDEELR----KLAKKPAE------------KVNGk--- 61 
XP_001629109   1 -lFGIQFVLSIIVATFLQKLSPYFSPARWILCNGwLVRYLHPTDEQLK----AMIGKPVNg----------tKGKGr--- 62 
ESO12572       2 ALFGVQVVFSMIVAFLLSKFTGQYSFGRWILCRK-LARYLHPTDDELR----KIAGSSGQ------------GSNKqhnk 64 
CDS37277      65 gaGAGGSYEGRNDpATFYFPRSTPFKLRKAEVRGHEIAVLPFYTDLVWLVDFSLCALLVLFANDfvsffrhvlpptlstn 144
XP_015785322  81 rgKRGRSDKNKAD-ENL-VPKKLALTLEAERVHSIDLIQLNFYKEYHWLIDFALYATIVYIISE---------------- 142
EFX86498     115 --KRKWAEEPVED-KTFTVPRNLDLQLETAKIFPKDVLQLKFFTEFVWLVDYSVFVLVVYLITE---------------- 175
XP_001942992  63 --SKRPIHAQNDNiDIFQIPKNLDIELESQPIQEHEIYQLRYFMEYQWLVNFSLYAALVYLSTE---------------- 124
EEB13811      65 --RYGKDNEQQVL-DTFHVPRDLDIQLKKSKVVPLDVMHLRFYSEYQWLIDFSVYAVVIYTLTE---------------- 125
XP_006563429  64 -----HTENGKVK-EVFHVPRNLDITLENTKITILDVVHLKYYTEYQWLLDFSIYATVVYVMTE---------------- 121
Q9VTF5        66 --KQANGSGGAAG-AQFHIPRSIEVELLTSPVLERDVVHLRYFTEYQWLLDFSVYTGIVYVVSE---------------- 126 fruit fly
2_pfamImport  62 -aRFRKNQQ-SEE-KSFKVPRNLEISLDMEPVRPMNVIVLRSYPDYEWLVDYSVFVLFVYLGTE---------------- 122
XP_001629109  63 --KSVNTESRYNK-NTFTIPCSLEIHLDKAKVEEIDVLPQFLYTEYKWLIDFAVSAAFLNLLIE---------------- 123
ESO12572      65 syKKLDPSKKAKD-ESFTIPKSADIQLEAVPIKPIDLLPLQYYGEYLWIVDVAVCGVIIFTLTD---------------- 127
CDS37277     145 kttsfflsMHSFFTPS----TINLNLVWSLFIVWFAMGSLFSVLRVYLGRssdneakvkeravsSSEWPLLMVTGFSSFI 220
XP_015785322 143 --------IQFYLIPEs--kEMNLSLIWCILVIGFTTKLLLTITGIYFRGnd----------daIGERSMCLVSGGLFFL 202
EFX86498     176 --------VYCGVFPKgn-qEVNLSMLWCLLLIGFALKSLCSVTSLYFWNte-----------aAAERSLVLVGGSFCFV 235
XP_001942992 125 --------IYSYYSPId--nEINLSMLWCSIVIVFAFKILMSLTLEYFRGgf----------esSGERSTVIVAACVHLV 184
EEB13811     126 --------TYQLIFQAq--dEVNLSMLWCFLVVGFAMKVLLSLTGQYFQSed------------sGERSTVIVTGFVYFV 183
XP_006563429 122 --------IYNYLYPIk--dEINLSMLWCSLVLGFAFKVLLSLWIQYFKGee-----------sIGERSTCIVTGFAYLL 180
Q9VTF5       127 --------LFHFYYPLr--hEVNLSMVWCLLVIFFALKLLSSLTVLYFQSee-----------sIGERSMVIVACLVYLL 185 fruit fly
2_pfamImport 123 --------LYYELWSPe--rEFNISMVWIALSVWFAVKNMISILWLYAKSn------------aGGEISMSISFGMMSFL 180
XP_001629109 124 --------VVAFFLPAvhkqEFNLGLFWNLMVVLFALKTMYSLTAAYWRGd------------dGGERSMCITFGLFFFV 183
ESO12572     128 --------IYYFFLHPs--rEVNLSIFWCLIIAMYSLKTLISLTSVYFKTe------------qSGERVLCLLFGFFFLV 185
CDS37277     221 AAMLCLSLDVSFLDLRISPAYGNLTFSLSPEASGSSAmSWG-------MFQACLAFYAAMVGVLFAFPSLQYGRIYVQTL 293
XP_015785322 203 FSMIVLIADENFLEFGLNPAYSTFNSNAIQFFEAHGLhESTkgvtsklLFKFWLAVWSGLIGALFIFPGIRFAQMHKDSL 282
EFX86498     236 LALGLLLIDESNLEIGLDAAYSSFNKSASVFLERQSM-DSEgpa-sklILKLCFAVWCGITGALFIFPGLRVSRMHLDAL 313
XP_001942992 185 IAMIILVIDESKLDVRLDTAYRSFNETSTAFLNNHGL-SSQgpa-sklIVKFFLALWCAVTGAMFVFPGIRTAKMHWDCL 262
EEB13811     184 LAMIILIIDENSLELGLETAYKVFNKNAIAFLERQGI-DSSgpa-skiVLKFFLALWCGIIGALFTFPGLRMARMHWDAL 261
XP_006563429 181 IAMTIFIVDENNLEIGLDKAYASFNHSASLFLNNQGL-SSTgpa-skiIVKFFLALWCGLLGSLFTFPGLRMSKMHWDIL 258
Q9VTF5       186 VAMVVLIVDERILETGLEDAYASFNASASKFLTEQGL-PSSgpa-skiVVKFFLAMGCGLLGSLFTFPGLRMAKMHWDSL 263 fruit fly
2_pfamImport 181 SGLAVLMVREDILEFGVDSVHNVTQHNSTMITQQFSLs----------GLKLLLAGFSAIYGTLIAFPAIRMAQMYTHAL 250
XP_001629109 184 VAMAVLVIDESLIDFGLDAGYEKFSTKAAEFLKKQGF-STRets-pvwVFKLMIAVMSAVLGMFMGFPGMRLANMYLDSL 261
ESO12572     186 FAMAILIVDEGTLDLGLESSYLNFSKATIAFMESQGL-EPHcpi-smtMVRIVIAISCAIIGTTLTFPGIRLAKMHVDAL 263
CDS37277     294 RDp-----------eSSWLTRLLFNLNLIAPQLTLLLWVVPLTARLPAlllqhagvalggaqmSTtwlsfvvicARALSS 362
XP_015785322 283 DYa-----------aGKPFQQFLFHTAFISPLLIILSWIKPIGRVYFS---------------EKvwp----nrgVLMAP 332
EFX86498     314 RYc-----------sERKVLKIFMYINLVSPFLLSLLWVRPLARHYFS---------------VRifg---nmeAPLMND 364
XP_001942992 263 RYyecnevhgkyfsySSTFIKGFMNFSLITHFLLVLLWVKPIAVDLLT---------------AKnls---glnKPLMTL 324
EEB13811     262 NYc-----------tDKKALKILLNVNFAMPFFITILWIKPISRDYLT---------------NRifh---gmsHPLMSS 312
XP_006563429 259 RYy-----------kDQKLLLLIANISYASPLLLISLWIKPISRDYLT---------------IRifs---gmsGPLMTT 309
Q9VTF5       264 KYc-----------rGNRLLQVLLNLSFVLPFILVILWIRPISRDYLT---------------VRvfq---gmqQPLLKP 314 fruit fly
2_pfamImport 251 KYs-----------rDNHLFNLVLHFNFFAPLIITLLWVKPLARDVIM---------------HPs-------lTPILTN 297
XP_001629109 262 YYh-----------kETPYMVLLLHLNFVMPVLIFATWIIPIVKEPLV---------------TGswhgkegpaTPLLTE 315
ESO12572     264 RYa-----------kESPGTSAMLYMNFIFTLLLSLLWVKPLFRDYFV---------------VKklk----nnqPLMTD 313
CDS37277     363 ERICSLRLLFTLFTVILRVAMTKRHMQAFLDTAQTRLDRLNREPGCITNREVQRIVASVFHCFNFAALQYLAPAMLLIGL 442
XP_015785322 333 VSFDTLRIVIILAIMIFRIILMPKYLQAYLNLAPRKLSKLTRESGKVKTEVIQRTVSGVFYYLCVVCLQYVCPLLLILFT 412
EFX86498     365 ATFDSMRLWLCVVFSIVRIVSAPSCFQAYLNLAQEKIENMKKEAGRISNVDLQRKIAIIFYYLCVVGLQFVAPVILCVGF 444
XP_001942992 325 EQFESLRCWLVVLVVFQRLYLMPTFMQAYLNMAHERLEQQKKEAGRITNKDLQKQVSVIFYYTCVVVLQYVIPLVMMLFF 404
EEB13811     313 TSFESLRLVIVLLAVTLHFCFMPLYLQCYLNMANSRIERIKKEAGRITNTDLQKRIAAVFYYLCVVALQYTAPILICLFL 392
XP_006563429 310 STFESMRLIAIIVAVLLKFLLMPIYLQSYLNLAMQRLENQKKEAGRITNIDLQKKIAAIFYYLCVVALQFIVPIIICLFF 389
Q9VTF5       315 HVFETLRLLLVIFVVVVRFALMPIYLQSYLNLAHDKIMDLRKEAGRITNVEFKQKISSIFYYLCVVTLQFAAPLILCLYL 394 fruit fly
2_pfamImport 298 YQFDISRIVFVVLVCILRLVLMRSHLQAYLNLAYEKLNKIKKESGMITNFELQRTVSHVFYYLGVVAMQYLSPIVFLLCS 377
XP_001629109 316 MAFKNLRSTLVLTFCALRLVLTWRHLQSYLHMAQDRMEKLRRETGRITNIELQRKVAGVFYYLSAASLQYLAPTVLLLFI 395
ESO12572     314 YQFEALRLLIILIFCVFRFLLVWVHLQAHLNMACDKVAELKKEVGRISSVELKKLVTRIYFYLCIVALHYLTPLILILFC 393
CDS37277     443 AFSYKASTGTG------------------------------WLP-----------------------------LAPQINV 463
XP_015785322 413 CILMKNLGDYQ------------------------------WLSlftgq-------------------stgvsEAYIFGS 443
EFX86498     445 TLMNKTLGGYG------------------------------WFGqhhynpdecdpqq---epkatlstllpndETTLVDA 491
XP_001942992 405 IFFYKTLGNFS------------------------------WVEvivnss-----------------ptidnsNQHSLLE 437
EEB13811     393 TFMYKTLGGFT------------------------------WTGdilkseyecpsdt----yksakenkflydnFSIKAS 438
XP_006563429 390 TFMYKTLGGYT------------------------------WEGllkapspeecpadq-lpkfisdvindydnEKTVVQT 438
Q9VTF5       395 TLMYKSLGGFS------------------------------WSGifresvvlqhecaasetegagvavsqgdgDFNIIES 444 fruit fly
2_pfamImport 378 ALCLKSLGGFS------------------------------WKEfspsfvansti-------tmaanstmltrESTFVEM 420
XP_001629109 396 SLILRTLELTD------------------------------WDSvadlgp------------------srieySHLISNT 427
ESO12572     394 TLLLKTLGNFSiphlllgtalyepaskslqsnqlfnitkhlWDSes--------------------------tGDLIVNT 447
CDS37277     464 ASSPSTSLASLietfagqdwDLIFTASWFsalqhtreafgelweslrcqagyvcQGVLGFALFWCLAAWQAVAVTGVAYH 543
XP_015785322 444 SEQFS--LKEL---------RAVFNPVFF-------------------------RGVLGYMSWWLSVVWFTTSVIGFIYH 487
EFX86498     492 REQWLAALSTF---------HQIFSYEVF-------------------------RGIFGFANWWMQFLSFFTIGCGLAYQ 537
XP_001942992 438 ANQAYFSIQSL---------KQVLTADVY-------------------------RGIFGFATWWICFSWFLSLSVGIFYQ 483
EEB13811     439 AHQFTLALESL---------KQVFTVEVF-------------------------RGLFGLTTWWTYFAWFATTSVGMVYQ 484
XP_006563429 439 AQDFQLTLSSL---------KQIFTVDVY-------------------------RGLLGLATWWSCFSLFATTAMGMFYQ 484
Q9VTF5       445 AQSLQASFSSL---------KNVFSTEVY-------------------------KGFLGFATWWSYFTLFATSSLGIVYQ 490 fruit fly
2_pfamImport 421 VASFNNGLHDI---------TDILTPQLL-------------------------RGVYSYVTWWGATNWFGASCMGLLYH 466
XP_001629109 428 TREAAL---DL---------RAVLTPELF-------------------------QGVFSYITWWLCTTWFVTSVFGVVYL 470
ESO12572     448 ATQFSSIVAQI---------KMLFPTSCY-------------------------YNLISFYCWWVCVAWFTTTSFGVLYH 493
CDS37277     544 RFV 546
XP_015785322 488 SYF 490
EFX86498     538 SYF 540
XP_001942992 484 SYL 486
EEB13811     485 SYF 487
XP_006563429 485 SYF 487
Q9VTF5       491 SYF 493 fruit fly
2_pfamImport 467 HYL 469
XP_001629109 471 KMi 473
ESO12572     494 TYF 496
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