Conserved Protein Domain Family
b_cpa1

?
TIGR00840: b_cpa1 
sodium/hydrogen exchanger 3
The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Statistics
?
PSSM-Id: 273294
Aligned: 5 rows
Threshold Bit Score: 665.712
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
P26433    45 KWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADh---IASFTLTPTLFFFYLLPPIV 121 Norway rat
P19634    95 DYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVG----ETPPFLQSDVFFLFLLPPII 170 human
P26434    63 DYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGSIIFGTHh---KSPPVMDSSIYFLYLLPPIV 139 Norway rat
AAA68274  29 DFEHTHKPLAFVFLIILVTLAKPTLHWP--VLRKLPESVVLMLYGVLMATAVKALMr---IDPGQLDTFMFFMILLPAIV 103 Caenorhabditis elegans
Q04121    55 TEEMFSSWALFIMLLLLISALWSSYYLTQKRIRAVHETVLSIFYGMVIGLIIRMSPghyiQDTVTFNSSYFFNVLLPPII 134 Saccharomyces cerev...
P26433   122 LDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVH 201 Norway rat
P19634   171 LDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIH 250 human
P26434   140 LESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLQNLLFGSLISAVDPVAVLAVFEEAR 219 Norway rat
AAA68274 104 NDAGLSMQKKEFTIALPKILLFAVVGTVVHALLLAATMYGIEPIFSFKP---GFLHLFVFATLISAVDPVSVLSTFAELD 180 Caenorhabditis elegans
Q04121   135 LNSGYELNQVNFFNNMLSILIFAIPGTFISAVVIGIILY-IWTFLGLESIDISFADAMSVGATLSATDPVTILSIFNAYK 213 Saccharomyces cerev...
P26433   202 VNEVLFIIVFGESLLNDAVTVVLYNVFESFVTl---gGDAVTGVDCVKGIVSFFVVSLG-GTLVGVIFAFLLSLVTRFTK 277 Norway rat
P19634   251 INELLHILVFGESLLNDAVTVVLYHLFEEFAN-----YEHVGIVDIFLGFLSFFVVALG-GVLVGVVYGVIAAFTSRFTS 324 human
P26434   220 VNEQLYMMIFGEALLNDGISVVLYNILIAFTKmh--kFEDIEAVDILAGCARFVIVGCG-GVFFGIIFGFISAFITRFTQ 296 Norway rat
AAA68274 181 VKKSLFILIFGESLCNDAVTIVLYRTSINVIKtsdasDEMLTITSVVGSCVVQFMIVCGfGLLCGAVVGFAGVFIMKNMV 260 Caenorhabditis elegans
Q04121   214 VDPKLYTIIFGESLLNDAISIVMFETCQKFHG------QPATFSSVFEG-AGLFLMTFSvSLLIGVLIGILVALLLKHTH 286 Saccharomyces cerev...
P26433   278 HVR--IIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISA 355 Norway rat
P19634   325 HIR--VIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVST 402 human
P26434   297 NIS--AIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVST 374 Norway rat
AAA68274 261 GHQ--MNQPIFQLFCPYLAYLLAETGHYSGILASILCAAIMSYYMAANMCVEMEFAAFTFSKTGSSLSESCIFFYLGVSL 338 Caenorhabditis elegans
Q04121   287 IRRypQIESCLILLIAYESYFFSNGCHMSGIVSLLFCGITLKHYAYYNMSRRSQITIKYIFQLLARLSENFIFIYLGLEL 366 Saccharomyces cerev...
P26433   356 VDP-VIWTWntAFVLLTLVFIS---------------VYRAIGVVLQTWILNRYR--MVQLETIDQVVMSYGGLRGAVAY 417 Norway rat
P19634   403 VAGsHHWNW--TFVISTLLFCL---------------IARVLGVLGLTWFINKFR--IVKLTPKDQFIIAYGGLRGAIAF 463 human
P26434   375 VGKnHEWNW--AFVCFTLAFCQ---------------IWRAISVFTLFYVSNQFR--TFPFSIKDQLIIFYSGVRGAGSF 435 Norway rat
AAA68274 339 VSYnHEFDF--YFIAVTVFCCT---------------LYRFLVTCTLSAFYNLFAseKNRIPFTDQLVVTHAGIRGAVCF 401 Caenorhabditis elegans
Q04121   367 FTEvELVYKplLIIVAAISICVarwcavfplsqfvnwIYRVKTIRSMSGITGENIsvPDEIPYNYQMMTFWAGLRGAVGV 446 Saccharomyces cerev...
P26433   418 ALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGH 497 Norway rat
P19634   464 SLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGH 543 human
P26434   436 SLAFLLPLTLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNK-KESINEELHIRLMDHLKAGIEDVCGQWSH 514 Norway rat
AAA68274 402 GLVQIIDERIIPAKPYFVTTTLAMIFVTSILQGCTIKFVMKCLKIPGDDG--TKQKDPKALRWLTHLN------------ 467 Caenorhabditis elegans
Q04121   447 ALALGIQG---EYKFTLLATVLVVVVLTVIIFGGTTAGMLEVLNIKTGCIS----EEDTSDDEFDIEAP----------- 508 Saccharomyces cerev...
P26433   498 NYLRDKWSNFDRKFLSKVLMRRSAQKSRdRILNVFHELNLKDAISYVAEGerrgSLAFIRSPstdnmvnvdfstPRPSTV 577 Norway rat
P19634   544 HHWKDKLNRFNKKYVKKCLIAGERSKEP-QLIAFYHKMEMKQAIELVESGgmgkIPSAVSTVsmq------nihPKSLPS 616 human
P26434   515 YQVRDKFKKFDHRYLRKILIRRNQPKS--SIVSLYKKLEMKQAIEMAETG----LLSSVAS-------------PTPYQS 575 Norway rat
AAA68274 468 DKYIKKFLVSENTYLPTDETFRNLGLP--KAVSTALRIGERSHTDLQRHG------EVSHT-------------PAPSVG 526 Caenorhabditis elegans
Q04121   509 -RAINLLNGSSIQTDLGPYSDNNSPDISiDQFAVSSNKNLPNNISTTGGN------TFGGLN-------------ETENT 568 Saccharomyces cerev...
P26433   578 EASvsyflrenvsavcLDMQSLEQRRrSIRDtedmvthhTLQQYLYKPRQEYKHlYSRHELTPNEDE 644 Norway rat
P19634   617 ERI-------------LPALSKDKEE-EIRK--------ILRNNLQKTRQRLRS-YNRHTLVADPYE 660 human
P26434   576 ERIq-----------gIKRLSPEDVE-SMRD--------ILTRNMYQVRQRTLS-YNKYNLKPQTSE 621 Norway rat
AAA68274 527 RPT-------------IAPFDFGNMEeENNR--------LPSTGRRTPVARSQTrYSRHFIYAIPNE 572 Caenorhabditis elegans
Q04121   569 SPN--------------PARSSMDKR-NLRD--------KLGTIFNSDSQWFQN-FDEQVLKPVFLD 611 Saccharomyces cerevisiae S288c
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap