6XP5


Conserved Protein Domain Family
Med11
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pfam10280: Med11 
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Mediator complex protein
Mediator is a large, modular protein complex that is conserved from yeast to human and conveys regulatory signals from DNA-binding transcription factors to RNA polymerase II. Not only are the polypeptides conserved but the structural organization is also largely conserved. One or two subunits are either fungal or vertebral specific but Med11 is one of the subunits that is conserved from fungi to humans. Med11 appears to be necessary for the full and successful assembly of the core head sub-region.
Links
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Statistics
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PSSM-Id: 463042
Aligned: 84 rows
Threshold Bit Score: 67.2725
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6XP5_K        28 AERIQQLGEIDNDIASLLQHLSAALKALATppgkrifqeqdsesnspsasdtsnpndTPPSSCGIDPVTAFKTAQNDFFR 107 Chaetomium ther...
EFA79080       1 mnSLTVLNNIEDRVVESINTAGKALNILSK---------------------------SLDIKQTTPSIQEFKQLSDRYFN 53 
XP_001640033   5 RDRLKQLEEIEKDIVKVMQSAGETIAELSN---------------------------------ENPSEDMVNMKATEFVK 51 
OWR51048       5 iERIQVLDEIEKDIITCLQCAAQALLELGK---------------------------------EKSSQKQAESNTSQFLR 51 
OXU28919       5 mERIQILEAIEKDIITCLQSAGQAFMELSK---------------------------------DKPNSKQAEGQTHQFIK 51 
BAH71487       5 mERIQALELIEKDIITCLQSAGQALLELSK---------------------------------EKSSLKQVENQSHQFLK 51 
XP_974541      5 mERIQVLDSIEKDIITCLHSAGQVFVELSK---------------------------------EKSSLKQAENHTQTFLK 51 
XP_007236272   3 NDRLRALEDVEKEIAVVLQCAGTIILELSK---------------------------------EKHNASLLDRQLNQFQT 49 
Q6P255         8 NERLRALEEIEREIAAILLNAGNVILELSK---------------------------------EKPNERVLDKQATQFTA 54  tropical clawed...
XP_007625140   8 NERLRALEDIEREIGAILQNAGTAILELSK---------------------------------EKTNERLLDRQASAFTT 54 

6XP5_K       108 TIDR-IDKHLTRQIYALEEAGIitlksgtgsgagtvgagateeqaqqlpqpqmipgqpqaagitadasvapvpKARLEPD 186 Chaetomium ther...
EFA79080      54 IVEKdVYKGLMEFVDSMTD------------------------------------------------------VAPFDHS 79 
XP_001640033  52 SLEG-VEKGLTEQINYLTQVAT---------------------------------------------------GQPHEGS 79 
OWR51048      52 TLSQ-VESKLSDQINYLTQVST---------------------------------------------------GQPHEGS 79 
OXU28919      52 TLGL-VESKLSDQINYLTQVST---------------------------------------------------GQPHEGS 79 
BAH71487      52 SLGN-VESKLTEQINYLTQVST---------------------------------------------------GQPYENS 79 
XP_974541     52 TLGA-VESKLTEQINYLTQVST---------------------------------------------------GQPHEGS 79 
XP_007236272  50 SLNR-VESELSSQIRYLTQVAT---------------------------------------------------GQPHEGS 77 
Q6P255        55 SVQR-VESELSGQIRYLTQVAT---------------------------------------------------GQPHEGS 82  tropical clawed...
XP_007625140  55 SVQH-VEAELSAQIRYLTQVAT---------------------------------------------------GQPHEGS 82 

6XP5_K       187 GMGRYGKLDVGR-----LNMASSIVEREMEGELwrK-AREHL 222 Chaetomium thermophilum var. thermophilum DSM 1495
EFA79080      80 SYSNKCELDVSHnfteiILLHL-------------EeMEEIL 108
XP_001640033  80 TYGVDKDFELATsrtaiVKGQLQEVQKILKNptvakt----- 116
OWR51048      80 GYASQKVLQMAWhrlehVRSWVNELERLKASHMaassrsnsn 121
OXU28919      80 GYESQKVLQMAWhrlqhVRSRVDELERLKNKhmhsrslaalg 121
BAH71487      80 GYASQKVLQMAWhrlehARSRVKELERSKNKYLqdqeqlkgn 121
XP_974541     80 GYASQKVLQMAWhrlehARSRVNELDRLKLKHmqgrrvqppn 121
XP_007236272  78 TYSARKDCQMALnraeyARVKLGELGRT---------CELML 110
Q6P255        83 SYSARKDGTMALnridyARVKLAELSRT---------CDQML 115 tropical clawed frog
XP_007625140  83 SYSSRKDCQMALkrvdyARLKISDVVRT---------CEQML 115
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