6XTX


Conserved Protein Domain Family
CDC45

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pfam02724: CDC45 
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CDC45-like protein
CDC45 is an essential gene required for initiation of DNA replication in S. cerevisiae, forming a complex with MCM5/CDC46. homologs of CDC45 have been identified in human, mouse and smut fungus among others.
Statistics
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PSSM-Id: 460663
Aligned: 110 rows
Threshold Bit Score: 331.81
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XTX_E        19 VLLFVA-SDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAF---------LEHK-------EQFH-----YFILIN 76 
Q4Q3V5        25 INVLVA-PTADAAAASLSLTYLMKVFLFPFQLHPTSSYDELKWFIe-------qANFAqds-ereDDISlriddLFILVG 95  Leishmania major
XP_002009890  19 ILIIVN-YDVDAICASKILQSLFKYDHMLYTVVPIMGVTGLKRAYs-------eHQAD---------VK-----YVLLIN 76 
XP_001696501  27 VMCFAAcTDADSVCASQQLMNLFNREGIFFTLIPVDSYEEVKAHCe-------pLVQA-------EEVK-----TVVLIN 87 
XP_002989665  26 LHILPStVDADSVCALKIFRSILNADNVRHSVFPVSRMADVGSRAa-------aIQAE--------EPV-----VVLLIN 85 
XP_006663773  29 LLILPSaADADALCALKVLTHVLSADSIRFSIYPVASAAAAASLLa-------sFSAS--------QPL-----CLLLIN 88 
XP_020187916  32 LLILPSaADADSLCALRILAHVLSADSVRFSVYPVASTADAAELLa-------sFSGAtassplsPPPL-----CVLLIN 99 
EES07916      30 VLILPSaADADSLCTVRALAHVLAADSVRFSVYPVASAAAARALLa-------sFSASas----asSPL-----CLVLVN 93 
KRH46661      25 VLIFPStSDVDSLCALKIIFHILESDSIQYACYPVSSFHEIHKYTn-------sSSND--------EPL-----SVVLVN 84 
EFH59832      27 LLIFPStSDVDSLCALKVITHILESDSIQYSCFPVSSFLEIHKYAgpaglcstsSESP---------PV-----TILLIN 92 
6XTX_E        77 CGANVDLLDILQPDEDTIFFVCDTHRP-VNVVNVY-NDTQI-----------KLLIKQDD---DLEVPAYEDifrdeeed 140
Q4Q3V5        96 LGAPVLLEDYFDFT-RHIVIVLDAYRP-FHLGNLCredgdr-----ciiwgsDRIQVEVD---DFFRKQRAEeaqrrrrh 165 Leishmania major
XP_002009890  77 CGGCVDIVELLQPAEDVTFYICDSHRP-LDVCNVY-SDRQVcilg---------dpaLEEnipGFESIFYDSegedgddd 145
XP_001696501  88 CGATDDIRSLCELPDNVRIVIIDHHRPvWHGHNVe-DDTNTlvlvd------eddpvPKAsvpVYNPNEQEEdeedsgse 160
XP_002989665  86 WGGTQDLRRQLKLGPRVLVFVVDSHRP-IHLNNWSdHNQQVtvlytreeemeRDIVYDFD-------VGSLAdfsfmtaa 157
XP_006663773  89 WGAHRDL--RAVLPPAATAFVVDSHRP-IHLHNLSaANDRVvvlfttddehtADLSYDFD-------VSSLAdasdlsaq 158
XP_020187916 100 WGARSDLLRGI-LPRGSTAFVVDSHRP-VNLRNLAaGNDRVivlftadderaADLSYDFD-------ASSLAdasdltae 170
EES07916      94 WGAHWDLVRAAVLPDTATAFVVDSHRP-VHLHNLCaRNDRVvvlftaddeqaADLSYDFD-------LAALAdasdlaae 165
KRH46661      85 WGNHRDLSNTLNLPSNARVFVVDSHRP-IHLRNLSdQNDAVvvlftkedegqSDLAYDFD-------LTTLAnaattvds 156
EFH59832      93 WGCHRDLKLVLKLGPAARVFVVDSHRP-IHLHNLSdYNEQVvvlhtddderqADLAYDFD-------VLKLAnesfqlhv 164
6XTX_E       141 eehsgndsdgsepsekrtr-----------------------------------------leeeiveqtmrrrqrrewea 179
Q4Q3V5       166 rrrldmkrhegharrqrtegggaqdddvysdessistsseeeesadsdgdeaadlfdgedddatpsqsqdrvdwrsapge 245 Leishmania major
XP_002009890 146 ddededgdengdsgagesddgngdgdss-----------------------ervrapklsrmqkheqrilrqrarrqwes 202
XP_001696501 161 aseaekddeedqeagvsgdgdededdlgvrpg---------------rkrrrrstgadqeerpakrspearaqaraerrk 225
XP_002989665 158 sdgeededeeesddeeeldgggggdk----------------------------hdnmrkrgrgrgrddssdhadnlrrd 209
XP_006663773 159 gdaddhlrvaeededsddsdsdsd--------------------------------aeggrrkrrrlsddadadgdperl 206
XP_020187916 171 gdadddhlraseeeesdtsdydsg-------------------------------aeggrrkrrwasddaeadgddpvrl 219
EES07916     166 gdadadplraasgsdasdyedsdadede-----------------------dvsggggrrkrrrlsddadadadsdpvrl 222
KRH46661     157 dsdsesesesdsdsdsgsertg-----------------------------------srkrrkknpqddddgddedpikl 201
EFH59832     165 eeggesdeeeeeeedeeeeded-----------------------------------dddddgdgdrpskrrkmgdgvkv 209
6XTX_E       180 rrrdilfDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQ------RHVSRHN 253
Q4Q3V5       246 vpayleaLYYACSCAGRSSAVEVYDLSVILHRFNDTILWHAAVGVCDLYLRRLVDYATYLVEMGPLEeavslqQSVRRgi 325 Leishmania major
XP_002009890 203 erdrimfDYTQFSYYGRSTALYIFELAWKLSKDNMDLLWWAIVGISEQLLLGKIESAAYTLELENIQ------SHVSRLT 276
XP_001696501 226 laelidaYYSDCNGYGKPSSLLLFALVNTAQHDDNFHLWCAIVGLTEQLLFHQISKQQYNTWREGLE------QKTHVqa 299
XP_002989665 210 mrrrkkdYYSTGTFHGRAAGRQVYDISHALHINTHELLWLACVSLTDQFVHERLTMERYQSGVMELD------TYVKT-- 281
XP_006663773 207 fgklrreYYRLGTFHGKPSGCLMYDLAHAMRKNTNELLWLACVSLTDQFVHERITNERYQAAVMELE------QHING-- 278
XP_020187916 220 fgrlrreYYRLGTFHGKPSGCLMYDLAHALRRNTNELLWLACVSLTDQFVHERITNERYQDAGMELE------QHING-- 291
EES07916     223 fgrlrreYYRVGTFHGKPSGCLMYELAHALRRNTSELLWLACVALTDQFVHDRITNERYQAAVMELE------QHVNG-- 294
KRH46661     202 yrklkkgYYKLGTFHGKPSGCLMYELADKLRKNTNELLWIACISLTDQFVHERLSDERYHDGVMELE------QHINS-- 273
EFH59832     210 fkklkrdYYKMGTFHGKPSGCLLFELSHMLRKNTNELLWLACVALTDQFVHERLTDERYQAAVMELE------QHINS-- 281
6XTX_E       254 HR-------------NEDEENTLSVDCT------------RISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWS-VHG 307
Q4Q3V5       326 l--------------------rdRTDEAvnsyhrastnsmQLSNREEEQLYLLRHSTLWDAIWYDSQVASALDLHHvEDG 385 Leishmania major
XP_002009890 277 Nk---------------------TNDQNtms-------asKINFENDLHLVLYRHWTVTESMRYSRYSACKLKLWT-LRG 327
XP_001696501 300 dp------------------qeeLDNEAangllhiprqkvHVEPFDDLRLTLLRYWTIEDSLRYTGYVAARLQTWR-QKG 360
XP_002989665 282 -Sgnsem---vtkvtMKDGTVVKAPDRS------------RITNDEEPRLMLLREWTLYDSMLCSSYVATKLKTWS-DGG 344
XP_006663773 279 -SgnldpsgvgsvvtLKDGTKIRAPEAS------------RIAYEDEPRLMLLREWSLFDSMLCSSYVATKLKTWS-DNG 344
XP_020187916 292 -SgnldpsgvgsvvtLKDGTRIRAPETS------------RIAYEDEPRLMLLREWTLFDSMVCSSYVATRLKTWS-DNG 357
EES07916     295 -SgaldpsgagavvtLKDGTKVRAPEAS------------RIAYEDEPRLMLLREWSLFDSMLCSSYVATKLRTWT-DNG 360
KRH46661     274 -Sgnlda---vtsvtLKDGTKIRAPNSL------------RITYEDQPRLMLLQEWSLFDSMMCSSYIATKLKTWS-ENG 336
EFH59832     282 -Sgnidk---itsvtLKDGTKVRAPDCS------------RISYEEEPRLMLLREWTLFDSMLCSSYIATKLKTWS-DNG 344
6XTX_E       308 QKRLQEFLA-DMGLPLKQVKQKFQAMDISLKENLREMIEQSANKFGM--KDMRVQ---------------TFSIHFGFKH 369
Q4Q3V5       386 RPRLSQLLAsRCGVSIAMAQRPWCEVPTDVGSEALRRVQ----------VELQNWvnaqgnfiayrnrirCISRKVGYST 455 Leishmania major
XP_002009890 328 EKRLHELLV-EMGLPLVHARQTYSAMDLILRKEFYSMVEQLAEKYGI--PDIVYG---------------TFTLSYGYRS 389
XP_001696501 361 LDNLRSLLT-YMCIPLKHATTAYKGLREVYNSQLRAQLPRFAPQHMLawDSLHLS---------------SFRLLYKHE- 423
XP_002989665 345 LKRLKLLLA-TMGIALVEGQQKYEYMSGETRRRMKEEFQRSSPQFGL--TDLYYR---------------SFQKLHGYSS 406
XP_006663773 345 LKKLKLLLA-RMGFPLADCQKRFQYMSMEVKRKMRDEFDRFLPEYGL--TEFYYR---------------SFLRVHGYRS 406
XP_020187916 358 LKKLKLLLA-RMGFPLADCQKGFQYMSMEVKRKMRDEFDRFLPEYGL--TEFYYR---------------SFLRVHGYKS 419
EES07916     361 LKKLKLLLA-RMGFPLADCQKSFQYMSMEVKRKMRDEFDRLLPEYGL--TEFYYR---------------SFLRVHGYRS 422
KRH46661     337 IKKLKLLFG-TMGFALGDCQQKFQHMNLEVKRKMKKEFERFLPEYGL--TDFYYR---------------SFIRTLKYSS 398
EFH59832     345 IKKLKLLLA-RMGFALIECQQKFPYMSHEVKRKMKQEFDRFLPEYGL--NDFYYR---------------SFLRLHGYSS 406
6XTX_E       370 KFLASDVVFATMSLMESP----------------------------EKDGSGTDHFIQALDSLSr-sNLDKLYHGLELAK 420
Q4Q3V5       456 EVSTFDVCKLFTAEMAAVppasvyvierspanaslspeevaalaqrKLVEFQRGQFWRASAVLDidpNEKLFHEALAGAL 535 Leishmania major
XP_002009890 390 RYAAADYVYALLAILQSv----------------------------KKHKTPEDCFMEASDALSr-qHKQLLNVGIDNAK 440
XP_001696501 424 EISASDMVFALLGLLTDAk--------------------------pKEKSWHRAAFNDASNALHvqrNLNVVEKGIELAK 477
XP_002989665 407 EVSAADVVYGLTALLEASc------------------------------DDHGGQFMRAYSALAp-kKWHELQQGMELAI 455
XP_006663773 407 KVSAADVVYGATALLESLnae----------------------skdSKGSSAAEQFWVAYSALSl-sNVDQLRKGMQSAI 463
XP_020187916 420 KVCAADVVYGVTALLECMsae----------------------sndSKECSAAEQFWVAYSALSp-sNVDQLQKGMQSAI 476
EES07916     423 KVSAADVVYGVTALLESLnae----------------------skgSKESSAAEQFWAAYSALSl-sNVDQLQKGMQSAI 479
KRH46661     399 KISAADVVYGVTALLESFv--------------------------rSDGSCASKQFGVAYDALSl-nNIDNLRTGMHHAI 451
EFH59832     407 RVSAADVVYGITALLESFl--------------------------gSGGSSASKQFGEAYDALSl-nNLDKLRSGMQQAI 459
6XTX_E       421 KQLRATQQT-IASCLCTNL-VISQGPFLYCSLME--Gt-PDVM--LFSRPASLSLLSKHLLKSFVCSTKNRRc---KLLP 490
Q4Q3V5       536 SLQQAVADA-TGSMMQPGN-VQSSTGIHYALPSDpsKtsPTLE--SFCTMRRLSVLAERLFFTLSMSRRRDRraltALRP 611 Leishmania major
XP_002009890 441 LLHAAIFRQ-VQSCLEAHQ-VHSTGSFFYYVLQE------EHA--FFSYPYALALLAKFVLHGHVATTRVRQa---pDLP 507
XP_001696501 478 RMCSDVVHEcGLMITSGKVkGGRNADYRWVNVAE--S--NGLAnpRFTHPAVLKYMALFLRDATSHRYSSNDa----RRP 549
XP_002989665 456 KVQRAILRQ-GSLAVTKQGfVKNTKMFRWFKLED--G--HDVE--LLARPMALTKLCYFVMDALREQGAR-------SKP 521
XP_006663773 464 EIQRAILRQ-GSSAITKTGfIRSAKKFRWVKLDD--P--VDTD--KLCHPQALTKFCFFLMDALKERGAR-------MKP 529
XP_020187916 477 EIQRAILRQ-GSSAITKSGfIRSAKKFRWVKLDD--P--VDTS--KLCHPQALTKFCFFLMDALKERGAR-------TKP 542
EES07916     480 EIQRAILRQ-GSSAITKTGfIRSAKKFRWVKLDD--P--VDTS--KLCHPQALTKFCFFLMDALKERGAR-------MKP 545
KRH46661     452 KIQRAILRQ-GSAAITKNGcIRSGRSFRWLKLED--S--NDAT--LLGYPQALTKFCYFIMDALREKGAK-------MKP 517
EFH59832     460 KVQRAILRQ-GSAAITKTGcIRSGRKFRWVKIED--S--MDAK--YLGYPQALTKFCYFLMDALREKGAR-------MKP 525
6XTX_E       491 LVM-AApLSMEHGTVTVVGIPPETd------SS--------DRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRS 555
Q4Q3V5       612 LILsCV-LPQAR-----LAAPPTAssgsgsgLPcgpgtdalVPAVHWSRASGGVPSASAATAAGGVFMGGGAQV--EDTA 683 Leishmania major
XP_002009890 508 LIAtCP-LDASQGMCLLVGIAPv-------rED--------SPKNFFGKAFDQAAQKSKTNLLQDFFEPSIVQLRQSDLT 571
XP_001696501 550 MVV-AG-PPDEGGMCCVVAVHAKHisgn------------klqKNPFARPFIETASALHIFQQKSAFENTTFHLRKEEVG 615
XP_002989665 522 LVC-AI-RCPQSDKALVVGVSHRLrlg-------------aqmGNRFGSVFKTVAANLGVDFQQDGFDAAWIQTDAASVG 586
XP_006663773 530 LIC-AC-LSREPEKVLVVGVCGKPrlg-------------avkGNAFGNAFRSAAEEIGADYFHDMFESSWIVLDVVAVS 594
XP_020187916 543 LVC-AC-LGREPEKVLVVGVWGKPrlg-------------avqGNSFGNAFRSAAGEIGADYFHDMFESSWIVLDVVAVS 607
EES07916     546 LIC-AC-LAKEPEKVLVVGVCGKPrlg-------------aaqGNAFGNAFRSAAEEIGADYFHDMFESSWIVLDVVAVS 610
KRH46661     518 LIC-AC-VSQEPGKVLIVGVCGRPrlg-------------gaqGNAFGIAFRTAAEEIGTEFFHELFESSWIVLDASAVN 582
EFH59832     526 MLC-AC-ASQQPGKLLVVGVCGKPrlg-------------avrGNAFGNAFRKAAQESRADYFHELFESSWIVLDASAVN 590
6XTX_E       556 KFLDAL 561
Q4Q3V5       684 EYVVVL 689 Leishmania major
XP_002009890 572 RFLDAL 577
XP_001696501 616 PFLDRL 621
XP_002989665 587 AFMTQL 592
XP_006663773 595 SFMIRL 600
XP_020187916 608 SFMIRL 613
EES07916     611 SFMIRL 616
KRH46661     583 SFMVRL 588
EFH59832     591 SFMIRL 596
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