Conserved Protein Domain Family
Sarcoglycan_2

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pfam05510: Sarcoglycan_2 
Sarcoglycan alpha/epsilon
Sarcoglycans are a subcomplex of transmembrane proteins which are part of the dystrophin-glycoprotein complex. They are expressed in the skeletal, cardiac and smooth muscle. Although numerous studies have been conducted on the sarcoglycan subcomplex in skeletal and cardiac muscle, the manner of the distribution and localization of these proteins along the nonjunctional sarcolemma is not clear. This family contains alpha and epsilon members.
Statistics
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PSSM-Id: 461668
Aligned: 5 rows
Threshold Bit Score: 482.555
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VLQ0     2 KFLNLIVVVLA--LICNEVQGL--KLQANVGELFTYKIEPQLFNWTH-------QVISQQFRYRPSLKNYPDLPSWMRYM 70  fruit fly
EDW28835   2 QLLLLIVAALAclCLCNGAAGG--TLQANVGELFTYKIEPHLFNWTH-------QVISEQFSYRPTMRNYPDLPTWMRYE 72 
EDW04061   2 KIVLLIVGWLG--IACNGYKL---HLQANVGELFTYKIEPQLFNWTH-------QVISEQFRYRPSLENYPDLPSWMRYM 69 
ETN66251   6 lkLVLLAVVLV--PCCSGTETIyiTDDVSVSELFSLRIEPRMFNWSY-------EGLSEQFHYRSSLEGYPDLPSWIRYM 76 
O43556    32 TFLLTVYSIFS-------KVHSdrNVYPSAGVLFVHVLEREYFKGEFppypkpgEISNDPITFNTNLMGYPDRPGWLRYI 104 human
Q9VLQ0    71 YSHEYHAGFLYGTPPASSAGKDLSLDVVALNRQNYETRR--VVVTMFVAHKFPTPNVVQMKINNLNWVHLMDPGRRENLR 148 fruit fly
EDW28835  73 YSHEYHAGFLYGTPPETEAGKALSIEVIALNRQNFETRI--TDLAMSVCQKFPTPNVVQMKIDNLNWVHLMDPGRVENLR 150
EDW04061  70 YSHEYHAGFLYGTPPDSVAGKTLNLDLVALNRQNYETRQ--LIITMFVAHKFITPNVIQMKIDNLNWVHLMDPGRVENLR 147
ETN66251  77 YSTEYHSGFLYGTPPPRTADTRVPIEIIALNRMSYETKR--LVLMLAVHHKPVAKHVIQMKIDNLNWVHMMDPGRIENLK 154
O43556   105 QRTPYSDGVLYGSPTAENVGKPTIIEITAYNRRTFETARhnLIINIMSAEDFPLPYQAEFFIKNMNVEEML--AS-EVLG 181 human
Q9VLQ0   149 NIFR--NDLWPNSKEDLSVVFMESAVNMGGRLPLRPQQ-REGVIVHVGSFAQFSPRLQELQ---------EEVRPLYKLP 216 fruit fly
EDW28835 151 NIFR--KDLWPSSKEDLSVVFMESAVNMGGRLPLRPQQ-REGVIVHVGSVAQFSPRLKELQ---------EEVRPLYKLP 218
EDW04061 148 NIFR--KDLWPASKDDLSIVFMESAVNMGGRLPLRPQQ-REGVIVHVGSFAQFSARLKELQ---------EEVRPLYKLP 215
ETN66251 155 NIFR--NDLWPESRSDLHIIFMDSAVKLGARLPLRPQQ-REGVVVHLGSRAEFSGRMLDLQ---------EEVKPLYKIA 222
O43556   182 DFLGavKNVWQPER--LNAINITSALDRGGRVPLPINDlKEGVYVMVGADVPFSSCLREVEnpqnqlrcsQEMEP---VI 256 human
Q9VLQ0   217 SCTYK-RTSVQKIFENVGFKLDWCAFRMVGMESPTEILFHSGKQNEQQMPDDLNQRQ-------EDRWMGIAREDVPERN 288 fruit fly
EDW28835 219 SCTYK-RTSVQKIFENVGFKLDWCAFKMVGLESPTEILYHSGKQQNEQQPSGDEQLH-------NDRWMGITREDVPRRN 290
EDW04061 216 SCTYK-RTSVQKIFENVGFKLDWCAFKMVGIESPTEIHYHNNHQQQQQQPQQHFEEQ-------EERWIGIPREDVPVRN 287
ETN66251 223 SCTYK-RTSVQTTFENSGFKLDWCAFRLTSSDDDITALPHHPNESHKDG------DHtnlsgqhVERWDAPLKSEIPERN 295
O43556   257 TCDKKfRTQ---------FYIDWCKISLVD------------KTKQVSTYQEVIRGEgilpdggEYK---PPSDSLKSRD 312 human
Q9VLQ0   289 YIDEFAFAFAIPGMIFAILIGMLSAVLCFQHEKFYDPHSEFFFANIFHICEESCApqsassdsgaddGSESSSNSDYPMA 368 fruit fly
EDW28835 291 YIDEFAFAFAIPGMIFAILIGMLSAVLCFQHQKFSDPHSEFFFANIFHICEESCAqapsd--setdhESESSVFFESPIS 368
EDW04061 288 YIDEFAFAFAIPGMILAILVGILSAVLCFHHQKFYDPHSEYFFANIFHICEECCAktqsd----seadEDSSINLDYPMS 363
ETN66251 296 YSDEVAISFAIPGMIFALLLCGLTIILCFQHEKLQDDDSEYYFNYIFYICSDFLR------------MHKSSRHEYNMVP 363
O43556   313 YYTDFLITLAVPSAVALVLFLILAYIMCCRREG---------------------------------------VEKRNMQT 353 human
Q9VLQ0   369 STVQMVQCSDsksnQPITTLKSLKD----------------------PNFLLD-------------------NTSMRSQS 407 fruit fly
EDW28835 369 STVQMVKCAD----QPLTTLKSLKD----------------------PNFLLD-------------------NTSMRSQS 403
EDW04061 364 STVQMVQCSDtnpmQPVTTLKSLKD----------------------PNFLLD-------------------NISMRSQS 402
ETN66251 364 SNVQMVHYSPed-aHSTIKLKSLRD----------------------APFDVEpqrispsdsfyregsphisNMYMRPKP 420
O43556   354 PDIQLVHHSAi--qKSTKELRDMSKnreiawplstlpvfhpvtgeiiPPLHTDnyd--------------stNMPLMQTQ 417 human
Q9VLQ0   408 Pn---------------N 410 fruit fly
EDW28835 404 P----------------S 405
EDW04061 403 Pn---------------N 405
ETN66251 421 PpykltgnssgsptlnrN 438
O43556   418 Qnlphqtqipqqqttgkw 435 human
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