Conserved Protein Domain Family
WDCP

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pfam15390: WDCP 
WD repeat and coiled-coil-containing protein family
This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC). WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients.
Statistics
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PSSM-Id: 464697
Aligned: 27 rows
Threshold Bit Score: 756.837
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002188893   2 DLGKAKLLRTGLNALYQAIHPVHGIAWTDGKQVILTTLYYQNGELKFGDSSILGQFEHVHGLSWGPYCSTDTPALLAVQH 81 
XP_001509635  16 ELGKGKLLRTGINALTEAVHPIYGLAWTDGKQVLLMPLQ--NGEPGLSGSSVIGQFEHVHGLSWCPVFQANWPALLAVQH 93 
Q5ZKI7         2 ELGKAKLLRTGLNALHQAIHPVHGIAWTDGKQVILTSLHLHNGEPKFGDSSVVGQFEHVHGLYWGP-GPPDAPALLAVQH 80  chicken
XP_003215426   2 ELGKGKLLRTGLNALYQAIHPVHGIAWTDGKQVILTSLYLHNGEPQFGNSNVVGQFEHVHGLHWGPSCASDLPALLAIQH 81 
NP_001072871   2 ELGKGKLLRSGLNALYQAIHPVHGLAWTDGRQVVLTALHHNNEEPKFGNSIVVGQFEHVHGLYWGPFLGNDTPALLAVQH 81 
XP_015207391   2 DLGKAKLLRTGLNALHQALHPVHGIAWTDGKQVALTALYWANGEPKFGDTNVIGQFDHVLGLFWGPVCCTGSPALLAVQH 81 
XP_005449831   2 DLGKAKLLRTGLNTLHQAIHPVHGIAWTDGKQVCLTSLYFINGDVKFGDTNVIGQFEHVFGLFWGPLCCSDSPALLAVQH 81 
XP_007229773   2 DLGKAKLLRTGLNTLLQAIHPVHGIAWTDGRQVCLTSCYFVNGDPKFGDTNVIGQFEHVLGLFWGPLCCSGSPALLAVQH 81 
Q5RFV8         2 ELGKAKLLRTGLNTLHQAIHPVHGIAWTDGKQVCLTSLFSVEGEPKFGDTNVIGQFEHVLGLFWGPLCCSGSPALLAVQH 81  zebrafish
XP_018551733  12 DLGKAKLLRTGLNTLHQAIHPVHGIAWTDGKQVCLTSLYFINGEVKFGDTNVIGQFEHVFGLFWGPLCCSDSPALLAVQH 91  barramundi perch
XP_002188893  82 KKHVSIWQLVYSSAEKKKPLISQTCEVGEPFPLLSQGCVWHPKKEVLAVLTKRDASVLHAVRTDNTRVKAEIKSSGVIHC 161
XP_001509635  94 KKHVTVWELCYSSPEKNKLLVSQSCEVREPFPVLPQGCIWHPKKEILTILTNQDASVIYSVRCDSIIVKADIKASGLIHC 173
Q5ZKI7        81 KKHITVWQLCFNAADRNKLLVSQICDISEPFPVLPQGCVWHPKKEILAVLTTRDASVLHSVHLNNCRIKADIKGSGLIHC 160 chicken
XP_003215426  82 KKHITMWQLCYSVSERNKLMVYQISEISELFPILPQGCVWHPNKEILAVLTTRDTSVLHSIRVNSSRIKADIKGTGLIHC 161
NP_001072871  82 KKHVTVWQLCYSSLDKNKLVVSQTCEIGDPFPVLPQGCTWHPSKDILVVLTKRDVSVLYAVRYENTSIKADVKSSGLIHC 161
XP_015207391  82 KKHVSVWQLQLSTLEQNKLLCTQTCEMSEPFPVLSQGCVWHPKKDVLAILTKRDASVLFSVRVDNRRVKADIKGSGLIHC 161
XP_005449831  82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILAVLTKRDTSVLFSVRVDNRRIKADIKGSGLIHC 161
XP_007229773  82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILAVLTKRDASVLFSVRVDNRRVKADIRGSGLIHC 161
Q5RFV8        82 KKHVTVWQLQLSALEQNKLLCTQTCEMSEPFPLLSQGCVWHPKMDVLAILTKRDASVLFSVRVDNRRVKADIKGSGLIHC 161 zebrafish
XP_018551733  92 KKHVTVWQLQLSTLEQNKLLCTQTCEMSEPFPLLSQGCVWHPKLDILAVLTKRDTSVLFSVRVDNRRIKADIKGSGLIHC 171 barramundi perch
XP_002188893 162 ACWTKDGNRLVVAIGSTLHSYIWDNAQKTLNICSFCPVFDVGGYICAIEATLDFQIAVATELPLDNICGFNAGIAFDVPS 241
XP_001509635 174 ACWTEEGNRLVLAIGSALHSYIWDSTRKTLLPCSFCPIFDVGGYICATEATVGLQIAVATELPLDKICGLNAGMAFDIPA 253
Q5ZKI7       161 ACWTKEGNRLVVGVGSALHSYIWDDTQKTLNACTFCPIFDVGGYICAVEATLNFQIAVATELPLDKICGLNAGVAFEVPA 240 chicken
XP_003215426 162 ACWTEEGNRLVVGIGSALHSYIWDDDQKTLNACSFCPIFDVGGYICAIEATLNSQVAVATELPLDKICTLNAGISFEMPA 241
NP_001072871 162 ACWTKDGSRLVVAIGSALHSYIWDSKQKSLNACAFCPVFDIGGYICAIESTVDSQVAVSTELPLDRICALNAGIAFDVPA 241
XP_015207391 162 ACWTKDGTRLVVAIGSALHSYIWNDIQKSLNACSFCPIFDVGGYICAIESTEDAQVAVATELPLDKICGLNAGMAFDVSS 241
XP_005449831 162 ACWTKDGTRLVVAIGSALHSYIWNDIQKSLVACSFCPIFDVGGYICAIEATGEAQVAVATELPLDKLCGLNAGIAFDLPT 241
XP_007229773 162 ACWTKDGTRFVVAIGSALHSYIWNDIQKSLVACSFCPIFDVGGYICAIESTDEAQVAVTTELPLDKICGLNAGIAFDLPN 241
Q5RFV8       162 ACWTKDGTRLVVAIGSALHSYTWNDIQKSLVPCSFCPIFDVGGYICAIESTDEAQVAVATELPLDKICGLNAGMAFDLPN 241 zebrafish
XP_018551733 172 ACWTKDGTRLVVAIGSALHSYIWNDIQKSLVACSFCPIFDVGGYICAIEATGEAQVAVATELPLDKICGLNAGIAFDMPS 251 barramundi perch
XP_002188893 242 GTEGvslISQAALVLGDEeysmdtrrKSIDSDRSGVd-sVASSSSGPVDLTHILANHRRSDPSPLITLKRKDSAATNGQD 320
XP_001509635 254 DGESnsfPSQSTLLVADEelpkapgkAAQDPEKSTS-----SLSPDMVDLTHVHSNNPRPRPSPLLNLKPKDYLTGSGHD 328
Q5ZKI7       241 SIETesfPSQSS-LCGEEeysmdggkKVLDAEKPMS------AVTSPVDLTHILSSKPGADSSPLLHLRPKDYLTGSGQD 313 chicken
XP_003215426 242 EVVGnsvPSQTTSLSCEEehtvdvgkKLPDQEKSGSl---VTSASSPVDLTHLSSNKHRSENSPLINLKPKDYLTGSGQD 318
NP_001072871 242 SSEIt-iSSQPGLLLMEEefsmdvvqKSADSGSLTTd--SLATSPATLDLTHI-VNHSKADLNSLLNMKKKDYLTGSGQD 317
XP_015207391 242 ASETgslPSQSSVLVVDEdcfldsrrRSIDSERSLAlnsIASSTSGPLDLTHILANHRKSDPSPLIHLKRRDHITGSGQD 321
XP_005449831 242 ETETl-hSHGSH--MSDDdsllesrrRSFESERSYI------PSSGPLDLTHLLARHRRSDPSPLIHLRRRDTVTGSGQD 312
XP_007229773 242 ESDQs--SQQSPVVMLDQdvsldsrrRSFDSERSLPl--GFISSSSPIDLTNILAKHRKSDPSPLIHLRRRDNLTGTGQD 317
Q5RFV8       242 ESEGl--CRPSAALTVDTdyyl-drrRSCDSERSGH------ASSGPIDLTNLLAKHRKSDPSPLIHLRKRDNLTGTGQD 312 zebrafish
XP_018551733 252 ETVSl-qGQGSHVVVSDDdslldsrrRSFDSDRSYI------PSSGPLDLTHLLARHRRSDPSPLIHLRRRDTLTGSGQD 324 barramundi perch
XP_002188893 321 SSHLILVTFERKVTTTRKVTIPGILVPDIMAFDLRAQIVAVASNTSNIVLVYSVTSSSMPHIQQIQLEKNERPKGLCFLT 400
XP_001509635 329 SSHLILVSFEPKATTTRKVNIPGILVPDIMAFDPKAQVVAIASNTCNVILVYSLTPSSMPNIQQIQLAACERPKGVCFLF 408
Q5ZKI7       314 SSHLILVTFEKKVTSTKKVSIPGILVPDIMAFDIKTQTVSVASNTCNVILVYSLTSSNLPNIQQIQLEKNEKPKGLCFLT 393 chicken
XP_003215426 319 ASHLILVTFERKVTATKKVSIPGILVPDIMTFDSKAQTVAVASNTCNLILVYSLTSSHLPNIQQIQLEKSERPKGLCFLT 398
NP_001072871 318 SSHLILVNFEKKVTTTRRVSIPGILVPDILAFDPTAHIVAVASNTCSAVLVYSLTSSSVPNIQQILLEKNERPKGLCFLT 397
XP_015207391 322 SSHLILVTYERKVTTTRKVSIPGILVPDVIAFDPRGRTVAVASNTCNMILVYCVTASAMPNIQQIQLQKTERPKGLCFLN 401
XP_005449831 313 SSHLILVTYERKVTTTRKVSIPGILVPDIVAFDPHCSTVAVASNTCNMVLVYCITASTMPNIQQISLQQNERPKGVCFLN 392
XP_007229773 318 SSHLILVKYERKVTTTRKVSIPGILVPDIVAFDPRGSTVAVASNTCNMVLIYSIMASSMPNVQQIHLQKNERPKGVCFIN 397
Q5RFV8       313 SSHLILVTYERKVTTTRKVSIPGILVPDIIAFDPNGHTVAVASNTCNMILVYCITDSSMPNVQQIQLQKNERPKGVCFFT 392 zebrafish
XP_018551733 325 SSHLILVTYERKVTTTRKVSIPGILVPDIVAFDPRGSTVAVASNTCNMVLVYCITASAMPNIQQISLQTNERPKGVCFLN 404 barramundi perch
XP_002188893 401 DKLLLILIGKQRFPDPNLIPSSSSDRYVIRLMVKELMLEENS------SAFPETKQKMFYNFES--SVNIPGKRKFFENL 472
XP_001509635 409 NSLLLILVGKQKSTEPAFLPSSKSDKFSLHLMVKEILLEEED------SSVSSGSSPSDSPSAGddVLDVAGPGKSPENL 482
Q5ZKI7       394 NKLLLILVGKQKFTDPAFLPSSRSDKYMIRLMIKELIFEVAP------STSASVNGSCASVNGSlnLSNIP------HDV 461 chicken
XP_003215426 399 DKLLLILVGKQKLTDPAFLPSSRSDKYILRLMIKEVVGKEGS------SALSGVTQVC--------FTNVPVKRETIETH 464
NP_001072871 398 DKMLLVLVGRQKTSDPAFLPSSSSDKYLIRLMVKEVMFDEDS------SASSGGNTSVQASFDS--SMSIQDKKKLVESL 469
XP_015207391 402 EKMLLLLVGKQKSNDPAFLPSSNTDKYIIRLMTKELIYNEES------SSMTAFSQNSSNADSG---VSIPGMKKYFENL 472
XP_005449831 393 DKILLLMVGRQKSNDPAFLPSANTDKYILHLIAKELIYDGESpmssiiPSPSAQSHESTSNFCT-------GIRRHSEHL 465
XP_007229773 398 SKMMLLMVGRQRSNDPAFLPSSNTDKFVLRLMAKELLFDEDT------TSPVVQKPESPSNFHG--------VRRHSENV 463
Q5RFV8       393 NKMLLFMIGRQKSNDPAFLPSSNTDKYILRLTAKELVFDEES----------TTKSESPSQHHG--------IRRHSENF 454 zebrafish
XP_018551733 405 DKMLLLMVGRQKSNDPAFLPSSNTDKYILRLIAKELMYNAETpi---tPPPSAYNHESTSNFCA-------GIRRHSEHL 474 barramundi perch
XP_002188893 473 ATEDQ--PQSRELLIPRSTVIQSPSGRRRLIEEVKspsyeqSSSSSVSDldekr----lpgdSLVALETLDAEPMNRSVS 546
XP_001509635 483 PPASF--LKGEKLLIPGSDTP--FLGGKPLIEEVKspaceqNQPPRVSKrskte----isseRLMDLETLEVEPVSRSAA 554
Q5ZKI7       462 STDVH--PLSRGLLIPDRAALQSPTSRRKLIEEIKspgyeqSCLLNMSDlkekk----vslnFPPAVESLNAEPLNQSAS 535 chicken
XP_003215426 465 SSDTH--PLKDGLLLPGCNVPQSPKNRRKLIEEIKststdqSLSMNRVDskekk----lpkdFPQALEALDMEPANRSLV 538
NP_001072871 470 YKEGQ--SAHREILLPGGVAPPTYLRKKKLIEEIRsydgdqSPTSSANEfdd--------krSKLRVESLDTEPKNRSIT 539
XP_015207391 473 SKEERv-QGVKELLLPAGTVIQSPSGRRKLIEEVKsc--eqSPVASVTDfsdra----tsseSSIAIENFDNEPINRSAG 545
XP_005449831 466 SKDDRerPGIKDLILPGRGVVCSPGNRRRLVEEVRss--ehSPITSSVDlsdra----pssaSSVTVENFDMDHVSRMAS 539
XP_007229773 464 SKD----LAVRDLVLPGGSVIHSPNSRRKLIEELRss--epSPVPSSVDysdra----tsstSSITLENYDMDHISRMAT 533
Q5RFV8       455 TKEDR--LSIKDLILPGGSVIVSPSSRRKLIEEVRss--dlSPVASSADfsdr-----assaSSVTLENYDMDHITRMAS 525 zebrafish
XP_018551733 475 SKDDRerQGIKDLVLPGGGVIRSPGNRRRLVEEVRsg--epSPVTSSVDfsdrasdrapssaSSITVENFDMDHVNRMSS 552 barramundi perch
XP_002188893 547 LRGCGSPSRISSRPTSPKVQfnviqeasn----ypknsnlpSERGMSHISRNLERLCGSFNELQLSLSEISDLARNGRR- 621
XP_001509635 555 T---RRSLKESNTPAFPKVQvntqesl--------rppksnLPKKASRLLKDLERLYGSFSELQQRLAQLPDLKQNGKT- 622
Q5ZKI7       536 LST--TSLAFSNKPTSPKRQietaskipn-----syknnllsEKEASYFSKNVEKLSGNFTQLQHHVCELTELLKAGKR- 607 chicken
XP_003215426 539 LQGPESSSGVSNVPISQNKPlhspheisn----asktnllrNDKEASYISKNLERLCSSFAELQHQLFEVTELLKSGKK- 613
NP_001072871 540 L-GLDMDKKPNSRPTSPKSEcqkssppn-----fikhgemsPQQEILSISRNVERLCCNFAHLQQHLSELTDITRNGKRp 613
XP_015207391 546 LTVTGPTSRESSRPSSPRSEslerihsap---alpknnslpKEKTVDQLSQNLERLFARFSEVQQCLSEITDFTRNGKK- 621
XP_005449831 540 LAVAGQVSRDSSRASSPRFEpsdkihteptlpmpektpgkaKERALEQLVHNMERLFTRFAEVQQCLTEIRDYTQNGKK- 618
XP_007229773 534 LAVAGQASRESSRPCSPRYEpsekllsdp---pmlqnscssKEKNLEQLAHNMERIFARFDEVRQCLTEIKDYAQNGRK- 609
Q5RFV8       526 LAVAGQASRDSSRPCSPRYEtseklysd------atppknsKEKNLEQLTQNMERIFTRFAEVQQCLSEIREFTQNGKK- 598 zebrafish
XP_018551733 553 LAVAGQASRDSSRASSPRFElsdklhteptlpmpekapgpsRERALEQLVHNMERLFTRFADVQQCLTEIRDYSQNGKK- 631 barramundi perch
XP_002188893 622 ISLAYPCSQEPPVVHVTYQKSFSNGSiTEETKDVLLCDGKIHLSLVQQLFDLPVIEMKHG-SSWIVLTADKDGFVPLIFK 700
XP_001509635 623 SSALYPLSQEPSFVHVIYQKPHVGGS-VVERRTFLLCDGRLRLSVIQRTFGLSLVEMQHE-SLWIILAADSEGFIPLTFT 700
Q5ZKI7       608 NLPMYPSSQEPSFINITCQKQLSRND-SDERRSVILCEGKLRLSVVQQIFNLSLVEMQHG-SSWIVLTADSEGFVPLTFT 685 chicken
XP_003215426 614 TVPRYPSSRDPSFVNIIYQKESSGTV-TPEKRAVILCDGKLRLSVIQQIFNLVLIEMQHG-LSWIVLTADQEDFIPLTFD 691
NP_001072871 614 LSASYLPCRQAPYVTVVCQDAYHPEG-PAMKRSILLCDNKLRLGTIQELFGLSLIEMQLGpSLWIILTGDSEGFIPLTFL 692
XP_015207391 622 SMGAYPSSSDPPFVNISCQKQLSENVfIDERRPVLLCEGKLCLRVIQELFSLSIVEMLHG-PLWIVLVADGEGFVPLTFK 700
XP_005449831 619 APSVYPNASEPPYVNVTCQKQLSENVfIDERRPVLLCDGKLCLRALQDLFNLTIVEMMYG-PLWVVLVADADGFVPLTFK 697
XP_007229773 610 PFISYPAASEPQYIHVTCQKQLSENVyTDERRPVLLYDGRLSLRVVQELFSLTVVEMMHG-PMWIILVA----DADGFVP 684
Q5RFV8       599 IACSYPSAYEPQYVHITCQKQLSENVyTDERRPLLLCGGRICLRVVQELFGLTVVEMMHG-PMWITLVADADGFVPLTFK 677 zebrafish
XP_018551733 632 SLSVYPNASEPPYVNVTCQKQLSENVfIDERRPVLLCDGKLCLRALQDLFNLTTVEMMYG-PLWIVLVADVDGFVPLTFK 710 barramundi perch
XP_002188893 701 ATQEIII 707
XP_001509635 701 ATQEIII 707
Q5ZKI7       686 SMQEVVV 692 chicken
XP_003215426 692 TQQEVVI 698
NP_001072871 693 ANQEITI 699
XP_015207391 701 HRDEITI 707
XP_005449831 698 PKEELTV 704
XP_007229773 685 LTFKHKE 691
Q5RFV8       678 HKDELTI 684 zebrafish
XP_018551733 711 PKEELTV 717 barramundi perch
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