Conserved Protein Domain Family
Glyco_transf_17

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pfam04724: Glyco_transf_17 
Glycosyltransferase family 17
This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (EC:2.4.1.144). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, and tumour progression.
Statistics
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PSSM-Id: 428090
Aligned: 24 rows
Threshold Bit Score: 514.514
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007855798  10 RRRSITLIL-PLLFLASLSLFYIHnnlyQLRNLLSYSTRPIWDSADGPTEIIPHYYAEGL-ADAYTCQLHGWKRRENPQn 87 
Q9SKF0         8 KPPPVKLVFpTLIILFLTCLLCIL----TNFQTISYLFRPLWDKPPPPFKRIPHYYAENV-SMGHLCELHGWTPRLEPR- 81  thale cress
XP_006358295  22 RSHGKVIFI-VLLILVPILLFGIY----LHFHKISYFFRPLWDKPPPPFEHLPHYYAENV-SMDNLCRLHGWTLRPEPR- 94 
XP_002527177  12 RAPWKLFFL-ILLVLVPICVLGIF----VHIQKISYFFRPLWDNPPPPFKRLPHYYAENV-SMEHLCDLHGWSLRSEPR- 84 
XP_002324640  12 RVTFKVVFF-ILLILVPICVIGIL----THAQHVSYFLRPLWDNPPPPFKHLPHYYAENV-SMEHLCHLHGWSLRSEPR- 84 
XP_003549746  19 QKPPIFFCA-LLLLLLPICVVGIF----IHGQKITYFFRPLWDNPPAPFTSIPHYYAENV-SMEHLCRLHGWSLRSKPR- 91 
XP_002978663   7 RGRKILAAA-LVLVLI-LCLHAGY----SNFLSLSYFLRPVWDTPPKPFDFITHYFAHNL-SRSDLCELHNWEVRETPR- 78 
XP_001755575  18 KFKLLTLTI-FGFFSIVATLVYVY-----DYRTVTYFLRPIWDTPPKSFQIIPHYYADGM-NLSELCALHGWTHRPTPR- 89 
EDR09043       7 rtrSNVILL-FSFLFCTVILYLIVqnqyQLRNALSYATRPLWDSDSGPKDIIPHYHAEGLkADAHTCQLHGWEERRNn-- 83 
EKD01901       4 srQHRRFLF-LFLFVVVVSVLTFWsrlaLAWRDFGYLTRPLWDHPERPFTVVPHYPRSTL-SSSEWCSLHGWKPRTSTP- 80 
XP_007855798  88 vKVLDAVLMSSELDLLELRLNELDGVVDQFFIIESNTTFTGLPKETYYDSHKGR-FEKFESKILYQFLPGQLQTa---DH 163
Q9SKF0        82 -RVFDAIIFSNELDLLEVRWRELEPYVSKFVILESNTTFTGIPKPLFFDSNKER-FAFAEGKIVHGVFPGKKRStgqpYE 159 thale cress
XP_006358295  95 -RVFDGIIFSNELDLLEVRWRELYPYVTKFVVLEANTTFTGLPKPLYFSDHRER-FAFAEDKIVHGVFPGRIASle-lHE 171
XP_002527177  85 -RIFDGIIFSNELDILDIRWHELHPYVTKFVILESNTTFTGIPKPLFFASNRNR-FSFAEDKIVHGVFAGRTAIhg-lSE 161
XP_002324640  85 -RVFDAIIFSNELDVLEIRWHELYPYITKFVILESNTTFTGIPKPLFFDSNRSR-FAFAKEKIVHGVFSGRIAArg-kNE 161
XP_003549746  92 -RIFDAVIFSNELDMLEIRWHELSPYVSKFVILESNTTFTGIPKRLFFALNRER-FSFAKQKIVHDIYPGRIAVpg-sHE 168
XP_002978663  79 -RVFDAIIFSNELDLLEIRWRELYPFVTKFVLLEANGTFTGLAKPLFFAKNSYR-FLFAASKLFYREIWTRPLLe---NE 153
XP_001755575  90 -RVFDAVIFSNEVDLLEIRMRELMPFVTKFLVLESNATFTGKPKPLYFADQKDSrFKFIHPQLLYSNIPSRPQIp---NR 165
EDR09043      84 vRVLDAVLMSSELDLLEIRMNELDAVVDYFLIVESNATFTGLPKETYFAKNRAR-YAKFERKIIYRFLPGYPLQp---GQ 159
EKD01901      81 -KVFDAVIFSVEIDLLQLRLRELYDVVDGFVILESDRTFTGLPKNTTFADNKHL-FDWASDKIHYAFHEGHELKa---GE 155
XP_007855798 164 DAWKVEAETRTAMSSFLRgyTKTLPSDTtfIVIMSDLDELPSAHTIKLLRDCD-FGETIHLQLRNYLYSFEWLLGLNSWR 242
Q9SKF0       160 DPFLLEGQQRVAMNWLLR--EAGVSDGD--AVIMSDADEIPSPHTVKFLQWCDgIPDVMHLEMREYMYSFEFPVDYSSWR 235 thale cress
XP_006358295 172 DPFKLEGQQRIAMNRLLH--AAGIFEDD--LLIMSDTDEIPSHHTIKLLQWCDgMPPVMHLELRHYMYSFEFPVDYSSWR 247
XP_002527177 162 DPFVLESEQRAAMNSLII--RSGISHGD--LLIMSDTDEIPSPHTLKLLQWCDgIPPVLHLELRHYMYSFEFPVDYSSWR 237
XP_002324640 162 DPFVLEFEQRKAMSGLLR--SSGISYGD--LIIMSDADEIPSPHTLKLLQWCDeIPHAMHLELKHYMYSFEFPVDYSSWR 237
XP_003549746 169 DPFVLESKQRGAMNALLR--RAGISNGD--ILLMSDTDEIPSPHTLKLLQWCDgIPPIMHLELRNYMYSFEFPVDYSSWR 244
XP_002978663 154 SPFTTEVFQRQQMDRALV--AAGIEEGD--IVIMSDADEIPSWHTLELLRWCDgFPSPMHLQMRNYLYSFEFLVDEKAWR 229
XP_001755575 166 DPFDNEKHHRIAMGNFLR--TAGIQDGD--LLITADADEIPSAHTIHLLQNCDgYPSPMHLQLRNYLYSFEFLVDSNSWR 241
EDR09043     160 SAWDSEAHTRNTMTTLLRshIGGFPSGTqsVVLMSDIDEIPSQHTVELLKACD-FGTSIHLQLRNFLYSFEWYLGLSSWR 238
EKD01901     156 HPFDQEAQMRTSMNAALE--RAGVRQGN--LVLMSDVDELPRASTLELLKTCD-YGDVIHLQLANYVYSFEFLLGHDSWR 230
XP_007855798 243 ASVVKWNA-GGYYSHIKRSEQALADSGWHCSYCFRALSEFVTKMQGFSHSDRIgGNMDLLKSE---KIQEKICRGDDIFG 318
Q9SKF0       236 ASVHIYSRkWTQYRHSRQTDLILSDAGWHCSFCFRRLNEFVFKMKGYSHADRV-KRKEFLDYQ---RIQKHICKGYDLFD 311 thale cress
XP_006358295 248 ASVHIYNR-WTKYRHSRQTDVILSDAGWHCSFCFRNLQDFVFKMTGYSHADRV-RRTNFLKYS---RIQKLICEGADLYD 322
XP_002527177 238 ASVNVYGP-WTRYRHSRQTDLIFSDAGWHCSFCFRRLKEIVFKMTAYSHADRV-RRKDFLDYS---RIQKLICNGDDLFD 312
XP_002324640 238 ATIQIFGP-RTGYRHSRQTDLILSDSGWHCSFCFRRLQEFVFKMTAYSHADRV-RRNEFLNYS---RIQKIICSGDDLFD 312
XP_003549746 245 ATAHVYGP-RSQYRHSRQTDVIFSDAGWHCSFCFQYISEFVFKMTAYSHADRV-KRKYFLSHS---RIQDIICKGDDLCD 319
XP_002978663 230 PCVHLYQPgATKYGHFRRSDFILADAGWHCSFCFRHVSEILFKIRAYSHADRL-KASRLGSVDaeiRIQDAVCKGRDLFG 308
XP_001755575 242 SSVELYRK-ETQYRHSRKTDHCLADAGWHCSFCFRYIRDFVFKMKAYSHADRI-RRPSLLNPE---RIQKIICKGSDIFD 316
EDR09043     239 ASANLWNS-DSFYRHSKSGERVLADSGWHCSYCFRTIPEYVVKMRGFSHADRIgGRIDLLDPK---RIQNTICKGKDIFG 314
EKD01901     231 ASVRRHPS--TGYSHGRVSETLLGDAGWHCSFCFKHIADFQFKMQAYSHADR--SRAELLGEE---RIQKVICDGTDIFD 303
XP_007855798 319 MLPEAYSYLDLFYQMNLQPQK-SMVGLPKYLLENAQHFKFLLPGGCQRD 366
Q9SKF0       312 MLPEKYSFQELISKIGPIPPSaSAVHLPAFLIQNAARFRFLLPGGCLRE 360 thale cress
XP_006358295 323 MLPEEYSFQELIKKMGSIPRSaSAVHLPTHVIENTDKFRFLLPGGCQRS 371
XP_002527177 313 MLPEEYSFQELIKKMGPIPRSaSAVHLPAYLIENADNFRFLLPGGCLRS 361
XP_002324640 313 MLPEEHTFQELIKKMGPIPHSaSAVHLPSYLIENADKFRFLLPGNCLRt 361
XP_003549746 320 MLPEEYSFQELIKKMGSIPRSaSAVHLPAYLIENADKFKFLLPGGCLRP 368
XP_002978663 309 LLPEEYTFKELVAKMGNAARShAAVHLPLWLLRNAHKFKFLLPGHCLRE 357
XP_001755575 317 MLPEEFTYKELISKLGAVAKSfSGVHMPKYLLENAETYRYLLPGNCIRD 365
EDR09043     315 MLPEAYSYLDLFSQMSLDPLT-SAVGLPRYLLENAEKFRFLLPGGCVRK 362
EKD01901     304 MLPEAYSWSELARKMAPMQRTnSAMDVPRLLKEKPEQYRYLLPGGCERE 352
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