Conserved Protein Domain Family
FAM101

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pfam15068: FAM101 
FAM101 family
This protein family includes the actin regulators, Refilin A and B, however the exact function of this protein family remains unknown. Refilin is thought to stabilize peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localization and shape in the nucleus plays a role in cellular and developmental processes.
Statistics
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PSSM-Id: 464483
Aligned: 19 rows
Threshold Bit Score: 233.441
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005988985   1 MVGHLHLQGMD---EsLKGKNREGLLDSPDSGLPPSP--SPPFYSLssGilEGRAGGSTT-PIEPLGHSsrkeAREGKL- 73 
XP_003430674   1 MVGHLHLQGME---EsLKERSREGLLDSPDSGLPPSP--SPPFYALs-P--DGRAAGGSAiPTDPSAVA----PQEGRE- 67 
XP_003507862   1 MVGHLHLQAMG---Dt-REQSRDGLLDSPDSGLPPSPspSPPFYALspGtlDARA------TTEPPG------PNEAPA- 63 
XP_001235028   1 MVGHLQLQGMDe--S-LKEKSREGLLDSPDSGLPPSP--SPPFYs-----lSPGGGGGA----DPSASGqrreAKDGRG- 65 
5_pfamImport   1 MVGRLSKQDVPelvD-AKK-KGSGPLD-------------PHSWRLrtVtlAWGWGAREC-VCVCGGASpgsgPALTAFs 64 
3_pfamImport   1 MVGRLSLQDVPelvD-TKK-KGDGVLDSSDSGLLSSS--S--HWGD--GaaAPGSGSDHE-CKHVSSFQpfakPQQSLq- 70 
XP_006640307   1 MVGHLHLQAMD---EsLKGKTREGLLDSPDSGLPPSP--SPPFYSLspAilESRAGGSTT-PMEQQGFSyrkeSKEGKL- 73 
Q8QHA4         1 MVGHLHLQAMD---DsLKGKNREGLLDSPDSGLPPSP--SPPFYSLspGilESRSASCST-PTELQGYCrk-eSREGKL- 72  zebrafish
XP_003445595   1 MVGHLHLQAMD---DsLKGKNREGLLDSPDSGLPPSP--SPPFCSLspAliESRSGSCTT-PVESHHGYykkeSREGKL- 73 
6_pfamImport   1 MVGHLHLQAMD---DsLKGKNREGLLDSPDSGLPPSP--SPINWGLs-V------------PVMAAGGDsrrsRVSAKTd 62 
XP_005988985  74 ----LPYLLLNSAASDPRPKMHPIFFGESIEVKPEPSQEIRCNSEIKYDSEKHYRDHVYYAPIP-TVTAYSETVIAAPNC 148
XP_003430674  68 ----VPCAFPCTLVPEMRPRMYPVFFGESIEVNPQPGQEIRWNSEVKYDSEKHYRDDIFYVPVP-TVTSFSETIIATPNC 142
XP_003507862  64 ----ATSLFQSPPALEMRPRLLPVFFGESIKVDPEPAHEIRCNSEVTYTSERYFRDKIFYAPVP-TVTAYSETIVAAPNC 138
XP_001235028  66 ----MPYLLLNPSVLEIRPRMYPVFFGESIEVNPEPMQEIRCNSEVKYDSEKHYRDDIIYGPIP-TVTTYSETVIAAPNC 140
5_pfamImport  65 lswkTPASVPSALAAGCSPRLCPLSFGEGVEFDPLPPKEVRYTSSVKYDSERHFIDDVQL-PLGlAVASCSQTVTCVPNC 143
3_pfamImport  71 ----NPASLPAPLASGCLPRLCPLSFGEGVEFDPLPPTEVRYTSSVKYDSERHFINDVHM-PLGlAVASCSQTVTCVPNC 145
XP_006640307  74 ----LPYLLLNSSGTEMKSRMYPVFFGESIEVCPKPKREVRCNSEVKYDSDKHYRDNVYCAPVP-TVTSYSETVIAAPNC 148
Q8QHA4        73 ----LPYLLLNSQGPDAKSRMYPVFYGESIEVNPKPEKEIKFNSAVKYASDRHFRDQVYCALVP-TPTSFSETIVAVQNC 147 zebrafish
XP_003445595  74 ----LPYLLLNSTGTDPKTRMHPVFFGESIEVNPKPEKEIKCNSEVKYDSDKHYRDRVFCTPVP-TATSFSETVVAVRNC 148
6_pfamImport  63 lvltLPYLLLNSTNTDAKTRMYPVFFGESIEVNPKPEQEIKCSSEVRYDSDKHYQDRVYCAPVP-TATSFSETVVAVRNC 141
XP_005988985 149 TWRNYKSELIFEPKQKPLRFQTTTIIFPKHAKNIYRTTLSYNS---RNAKRWFMSSVQLEST 207
XP_003430674 143 TWRNYKTQLHLEPRPRPLRFQTTTIIYPKHAKNTFRTTLRCSL---GCPKRWFASSVRLELW 201
XP_003507862 139 TWRSYRSQLTLEPRPRALRFGSTAIIFPKLARNSFRTTLQCSL---GQPRHWFSSSLQLQRC 197
XP_001235028 141 TWRNYKSQLIFEPRQKPLRFQSTTIIFPKRAKNIYRTTLNYSL---GCAKRWFSSSVQLELC 199
5_pfamImport 144 TWRSYKAEVRFEPRHKPARFLSTTIVYPKYPKTVYTTTLDYNC---RKKLRRFLSSVELEAM 202
3_pfamImport 146 TWRNYRAEVRFEPRHRPARFLSTTIVYPKYPKTVYTTTLGYNC---RKTLRRFLSSVELEAP 204
XP_006640307 149 TWRNYKTELQFEPRQKPLRFQSTTIIFPKHAKNIYRTTLNYNG---SSADRWFVSRVQLESS 207
Q8QHA4       148 TWRSYKSEVHFQPRHRPLHFQSTAIVFPKHTRNTYRTTLNYNSnrnAAGRRWFVSTVRLEST 209 zebrafish
XP_003445595 149 TWRSYKTQVYLEPRQKPVSYQSTTIIYPKHAKNTYRTTLNYNA---TGSRRWYVSTVKLESS 207
6_pfamImport 142 TWRSYKSQVYLEPRQKPISYQSTTIIYPKHAKNTYRTTLNYNA---TGSRRWFVSTVQLESN 200
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