1GC5,1L2L,1UA4


Conserved Protein Domain Family
ADPGK_ADPPFK
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cd01938: ADPGK_ADPPFK 
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ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ADPGK has been characterized in mouse and is assumed to be desirable during ischemia/hypoxia. ADPGK and ADPPFK contain a large and a small domain with the binding site located in a groove between the domains. Partial domain closing is seen when ADP is bound, and further domain closing is observed when glucose is also bound. The oligomerization state apparently varies depending on the species, with some existing as monomers, some as dimers, and some as tetramers.
Links
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Statistics
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PSSM-Id: 238913
Aligned: 11 rows
Threshold Bit Score: 492.686
Created: 21-Sep-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:substrate binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                     #   #           
1GC5_A     11 LWKRLYVNAFENALNaip--------------------nvkGVLLAY-----------------NTNIDAIKYLda---- 49  Thermococcus litor...
1L2L_A      6 NWESLYEKALDKVEAsir--------------------kvrGVLLAY-----------------NTNIDAIKYLkr---- 44  Pyrococcus horikoshii
1UA4_A      3 TWEELYKNAIEKAIKsvp--------------------kvkGVLLGY-----------------NTNIDAIKYLds---- 41  Pyrococcus furiosus
P58847      5 EWEQRHAEAFYNAKEalp--------------------yldGMFVAY-----------------NSNIDAIRHLte---- 43  Methanosarcina ace...
BAC11699   60 AWDALIVRPVRRWRRva-----------------------vGVNACV-----------------DVVLSGVKLLqa---- 95  human
CAF98385   58 AWDTLITLPSRRWSRva-----------------------vGVNACV-----------------DVVVSGVGLLq----- 92  Tetraodon nigrovir...
NP_493657  52 SWERAIVKPGAMFKKav-----------------------iGFNCNV-----------------DLIVSGVRVVda---- 87  nematode
XP_413705 292 AWQAAIVRPARGWGRva-----------------------vGVNACV-----------------DVVLSGVKLLe----- 326 chicken
CAG11018   25 LWFRSPQNAVLDDRLdavlssl------------lraerkvGINAVArprvai-----gfggcvDLLVDGVTLLnk---- 83  Tetraodon nigrovir...
XP_316428  10 YWHSGKQNNSMFSLLstatmlg------------aftalfaIVFQAYltsnelvrltvilqhlrDLEVEYPVQGprvaig 77  Anopheles gambiae ...
AAK93124   23 IWQAFIALQTLNRTTvlltgllaiegslkrtalepapkvaiGYGACT-----------------DLQINATEFLdr---- 81  fruit fly

Feature 1                                                            #                        
1GC5_A     50 ----dDLEKRVTEkgkekvfeiie-----nppekissieELLGGILRSIklGKAMEWFveSEEVRRYLRewg------wd 114 Thermococcus litor...
1L2L_A     45 ----eDLEKRIEKvgkeevlryse-----elpkeietipQLLGSILWSIkrGKAAELLvvSREVREYMRkwg------wd 109 Pyrococcus horikoshii
1UA4_A     42 ----kDLEERIIKagkeevikyse-----elpdkintvsQLLGSILWSIrrGKAAELFveSCPVRFYMKrwg------wn 106 Pyrococcus furiosus
P58847     44 ----eDLSKLVGFfdesdiqdrva-----aypreiaeplDFVARLLISMreGKAAEVPayTADIHEWLKehl-----gfd 109 Methanosarcina ace...
BAC11699   96 ----lGLSPGNGKdhsil-----------------hsrnDLEEAFIHFMgkGAAAERFfsDKETFHDIAqvase--fpga 152 human
CAF98385   93 -----ALAVDPGTgadhev---------------lhskeDLKEAFLHYMerGAAAERFfsDSEVFQRIAraaaemfivfl 152 Tetraodon nigrovir...
NP_493657  88 ----lNTTCSEGKdqetl-----------------etlaDLHQTFAHFFqrGAAAERYmsSEDQFNLLVaesea--strs 144 nematode
XP_413705 327 -----ALGLKPGSgknhdv---------------lnsrqDLREAFTHFMekGAAAERFfsDAESFHHIAqtase--hpga 384 chicken
CAG11018   84 ----mGLTPADRPhhhdf----------------ienqvQLAQSFAYFFapGAAAERFvlNETLFSELVeasrd--ipgn 141 Tetraodon nigrovir...
XP_316428  78 ygscsDLHVRATDfleysdtigqtlnaseytfdditneeEFLLNFAYYFqrGAAAERFtaNREMFMGLVqrakksntvqh 157 Anopheles gambiae ...
AAK93124   82 ----yYGRRIPVAaattgsr------------avvnnedELLQSFAYYFqnGAAAERVmaNSTLFTQLVgyakvmdkeri 145 fruit fly

Feature 1          ##                                                                         
1GC5_A    115 ELRIGGQAGIMANLLGGVYripTIVHVpq----------------nPKLQAELFvd-gpIYVPVfegnklklv-hpkdai 176 Thermococcus litor...
1L2L_A    110 ELRMGGQVGIMANLLGGVYgipVIAHVpq----------------lSELQASLFld-gpIYVPTfergelrli-hprefr 171 Pyrococcus horikoshii
1UA4_A    107 ELRMGGQAGIMANLLGGVYgvpVIVHVpq----------------lSRLQANLFld-gpIYVPTlengevkli-hpkefs 168 Pyrococcus furiosus
P58847    110 YARMGGQAGIISNLLGRLGlkkVVAYVpw----------------lSEEQAEYFtatgnILHPKvengkvllkppgeafk 173 Methanosarcina ace...
BAC11699  153 QHYVGGNAALIGQKFAANSdlkVLLCGp-----------------vGPKLHELLdd-nvFVPPEsl-------------- 200 human
CAF98385  153 QLYVGGNAALIGQKLATYPdlmVQLQFtlifirvckenvivlllpvFVSSQVLLc---gPVGPKlhemldeqi-lvpaes 228 Tetraodon nigrovir...
NP_493657 145 HHHIGGNAALMADRIAANFp-sTEVYLvg---------------piGPRSQALLh---pSVKRTnst------------- 192 nematode
XP_413705 385 QLYVGGNAALIGQKLAANPdlkILLCGp-----------------vGPKLHELLdd-svVVPPEsm-------------- 432 chicken
CAG11018  142 RWTVGGNAPVMAGRMATEGc-dVLLGGsf----------------sPDFTDVLSq---hITVAGee-------------- 187 Tetraodon nigrovir...
XP_316428 158 HWALGGNAPVIGTRMAIEGa-nVLLGAkm----------------sAKLKTHLRp----EVQLTgs-------------- 202 Anopheles gambiae ...
AAK93124  146 NWYMGGNAPLMAVRFFMEGa-qVLLGAhm----------------sRKLRPLLPk---eIRLAGde-------------- 191 fruit fly

Feature 1            #                                                                        
1GC5_A    177 aeEEELIHYIYEFPRGFQVF----DVQAPRENRFIa---NADDYNarVYMRREFregFEEITRn--VELAIISGLQVLKe 247 Thermococcus litor...
1L2L_A    172 kgEEDCIHYIYEFPRNFKVL----DFEAPRENRFIg---AADDYNpiLYVREEWierFEEIAKr--SELAIISGLHPLTq 242 Pyrococcus horikoshii
1UA4_A    169 gdEENCIHYIYEFPRGFRVF----EFEAPRENRFIg---SADDYNttLFIREEFresFSEVIKn--VQLAILSGLQALTk 239 Pyrococcus furiosus
P58847    174 pgIGSKVNWILEYSKDMNVTcagnTFKVPRDNRLIissrPKWLRLd-MDKQIYE---QLDTLLp--VDGAMLSGYQMIKe 247 Methanosarcina ace...
BAC11699  201 -qEVDEFHLILEYQAGEEWG----QLKAPHANRFIf--sHDLSNGa-MNMLEVF---VSSLEEf-qPDLVVLSGLHMMEg 268 human
CAF98385  229 lqETDEFHLILEYKEGEQWS----STRAPQANRFIf--sHDVSNGe-MSALEVF---VASLDEf-qPELVVLSGFHMMEg 297 Tetraodon nigrovir...
NP_493657 193 riLKDELHVILEYKQGEILG----DWVAPSSSRFIt--sHDHFSGs-MVVMEMF---FKAIAQf-rPDLVVITGVHLLEf 261 nematode
XP_413705 433 -qERDEFHLILEYQAGEEWG----QVKAPNANRFIf--sHDLSNGa-LNMLEVF---VSSLEEf-qPDLVVLSGLHMMEg 500 chicken
CAG11018  188 -vEEPDIHLILEYPSGASWG----QYTSRRANRYIv---HSDDHNp-YLSSMED---FASKLEefqPDLLVVGGLQMMDn 255 Tetraodon nigrovir...
XP_316428 203 liEDDDIHLILEYNTGDSWG----DLVSPRANRYIl---HNDHHNp-YLSSLEE---FDSALAgfePHLFVVSGLQMMDn 271 Anopheles gambiae ...
AAK93124  192 -iPNDDIHLILEYKAGDKWG----PYVAPRANRYIl---HNDRNNp-HLRAVEQ---LTDALKmyqPQLLVVSGLQMMDm 259 fruit fly

Feature 1                                                                                     
1GC5_A    248 yyp--dgttYKDVLDRVESHLNILnry--nvkSHFEFAYtaNRRVREALVELLPKf--TSVGLNEVELASIMEIIG-DEE 320 Thermococcus litor...
1L2L_A    243 e-------nHGKPIKLVREHLKILndl--girAHLEFAFtpDEVVRLEIVKLLKHf--YSVGLNEVELASVVSVMG-EKE 310 Pyrococcus horikoshii
1UA4_A    240 e-------nYKEPFEIVKSNLEVLner--eipVHLEFAFtpDEKVREEILNVLGMf--YSVGLNEVELASIMEILG-EKK 307 Pyrococcus furiosus
P58847    248 eye--dgstYKDYVENSVKVIEKLkslnpelrIHVELTSiqNRLIRKAILTEIVArhvHSLGLDTVEVANALNVLG-HEE 324 Methanosarcina ace...
BAC11699  269 qsk---elqRKRLLEVVTSISDIPtg----ipVHLELASmtNRELMSSIVHQVFPa-vTSLGLNEQELLFLTQSAS-GPH 339 human
CAF98385  298 qgrqlwegrLKEAIAAISDIRKDFp-------IHLELASmtDKDYMNRIMQEQVMpivTSIGLNEQELLFLSQSGQ-GPH 369 Tetraodon nigrovir...
NP_493657 262 qs----kemRQEKMRLIKRNLLQIppk---vpIHLELGSlaDEIFSTDVINKILPy-vDSLGINEQELTFLSHIAN-GPH 332 nematode
XP_413705 501 qsk---emrHRRLMEAVASISDIPtd----ipIHLELASmtDQDFMSNIVHQVFPl-vNSIGLNEQELLFLTQSAS-GPH 571 chicken
CAG11018  256 fpf--rageRKALLSRLADLLSSSrpq---igVHFEMASfvEESIMEELLHYVVPh-aDSLGMNEQELPNLLSLLK-GTN 328 Tetraodon nigrovir...
XP_316428 272 yly--pvgvREKLLERVRTQMQAQsrt--atlIHFEMASfvELELLQLLLRTVLPy-sDSIGMNEQELDNLQQVLEtGRI 346 Anopheles gambiae ...
AAK93124  260 ftf--ksgeREARLQQVQRQLTSQpqg---tlNHFEMASyvELQLLQQLRHFVLPy-vDSLGMNEQELSNLQQVLA-HGR 332 fruit fly

Feature 1                                                                                     
1GC5_A    321 LAKEVLe----------gHIFSVIDAMNVLMDe-------------------tGIERIHFHTYg---YYLALTqyrg--- 365 Thermococcus litor...
1L2L_A    311 LAERIIskd-------paDPIAVIEGLLKLIKe-------------------tGVKRIHFHTYg---YYLALTrekg--- 358 Pyrococcus horikoshii
1UA4_A    308 LAKELLahd-------pvDPIAVTEAMLKLAKk-------------------tGVKRIHFHTYg---YYLALTeykg--- 355 Pyrococcus furiosus
P58847    325 LSYSVIrkg-------enGIMSLYQGAVQLMKd-------------------lDLERVHVHSLg---FYICILakghplt 375 Methanosarcina ace...
BAC11699  340 SSLSSWng--------vpDVGMVSDILFWILKehgrs-----------ksrasDLTRIHFHTLv--yHILATVd------ 392 human
CAF98385  370 SDLAAWkg--------ipDVGQVSDILLWILEehgrgd----------alseaDLTRIHFHTLa--yHILATVe------ 423 Tetraodon nigrovir...
NP_493657 333 MEEYPVqag-------tvHVHKVVEMLHWLLKtygrdptg-----qiasktgyRLSRIHFHCLt---YHIMVSsg----- 392 nematode
XP_413705 572 ASLASWng--------vpDVGAVSDILFWILKehgki-----------adrasDLTRIHFHTLa--yHILATVd------ 624 chicken
CAG11018  329 ITVLSDpn---------pRVATVLDQMREVYRilnrrhtdaaaegnpgaakvkALTRLHVHTLa---FQAIIVtr----- 391 Tetraodon nigrovir...
XP_316428 347 SLVADCnprvahsldqarAVFRKLNEDFYRKQsgagd-----------gatrrPLSRIHLHTLayqaFIVAKDsrw---- 411 Anopheles gambiae ...
AAK93124  333 TTLATDwn---------pRIAHTLDQMRQVFIslledyedr----sssdakrrSISRIHVHTLay-qAILTTAgskw--- 395 fruit fly

Feature 1                                                                                     
1GC5_A    366 -eevRDALLFASLAAAAKAMKgnl-----erIEQIRDALSVPTNEr--AIVLEEELEKEFtef-------enGLIDMv-- 428 Thermococcus litor...
1L2L_A    359 -ehvRDALLFSALAAATKAMKgni-----ekLSDIREGLAVPIGEq--GLEVEKILEKEFsl--------rdGIGSIe-- 420 Pyrococcus horikoshii
1UA4_A    356 -ehvRDALLFAALAAAAKAMKgni-----tsLEEIREATSVPVNEk--ATQVEEKLRAEYgi--------keGIGEVe-- 417 Pyrococcus furiosus
P58847    376 lkehRDSLLFSSVLAAAQALNgni-----enLAEAEAGLEVPVSSi-gLEDLENFQLYCTgrklctpdefeyGYVYGs-- 447 Methanosarcina ace...
BAC11699  393 ---gHWANQLAAVAAGARVAGtqac--atetIDTSRVSLRAPQEFm--TSHSEAGSRIVLnp--------nkPVVEWhr- 456 human
CAF98385  424 ---gHWGNQAAAVMAGARVASsqac--glqaVDVSKVELKAPLEFy--SSHSEPREKLILdp--------aePVTTWhr- 487 Tetraodon nigrovir...
NP_493657 393 ---tDWSNLAAGLAAGARIAGrlscnigantMDSELLEIRTPANFv-lDKKIEKNYQFEAh----------nPIASWmr- 457 nematode
XP_413705 625 ---gHWGNQVAAVAAGARAAGvqac--atetIDTSKVFLKAPLEFv--TSQIDAPSKISLnp--------dePVVHWhr- 688 chicken
CAG11018  392 --gsQWKNTMSATAKASLTANrhvc--gsndIDTSKARLIMDDSFs--VSRQEGSQRILLqe--------tkPVNCWpe- 456 Tetraodon nigrovir...
XP_316428 412 -qytKNAAAKASLTAHRHVCAtt-------iVNPDAAYLQMDGSFa--VSASPGARRIHFnn--------rdPVSCWeea 473 Anopheles gambiae ...
AAK93124  396 -kntRAAAAKAALTAHRYVCKsq-------fINPEAVLQVLDDSFatsAQADAPRMRIGAa----------sPVPCWrey 457 fruit fly

Feature 1                                 #   #           
1GC5_A    429 ----------DRQLAFVPTKIVASPKSTVGIGDTISSSAFVSEF 462 Thermococcus litoralis
1L2L_A    421 ----------DYQLTFIPTKVVKKPKSTVGIGDTISSSAFVSEF 454 Pyrococcus horikoshii
1UA4_A    418 ----------GYQIAFIPTKIVAKPKSTVGIGDTISSSAFIGEF 451 Pyrococcus furiosus
P58847    448 ----------EHDAILIPSKVVERPKATVGIGDTISAGAFVAML 481 Methanosarcina acetivorans
BAC11699  457 ---------eGISFHFTPVLVCKDPIRTVGLGDAISAEGLFYSE 491 human
CAF98385  488 ---------gSVTFHMTPVLVCTHPLRTVGLGDAISAEGLVYSE 522 Tetraodon nigroviridis
NP_493657 458 ---------eDVLFVFTPVLVCRLPSKTVGIDDAISATGLLYSQ 492 nematode
XP_413705 689 ---------eGISFHFTPVLVCKDPVRTVGLGDAISAEGLLYSE 723 chicken
CAG11018  457 ---------dDYEICVAPVLVCTEVYQTAGGGDNVSAAGLVLQI 491 Tetraodon nigroviridis
XP_316428 474 lelpeagrtiAVELCVAPVLICKNAKQTVGAGDNISGAGLVLQI 517 Anopheles gambiae str. PEST
AAK93124  458 iqygrhrqrlEVEICVAPVLVCREARKTAGAGDNISASGLAAQL 501 fruit fly

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