Conserved Protein Domain Family
rRNA_processing
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pfam08524: rRNA_processing 
rRNA processing
This is a family of proteins that are involved in rRNA processing. In a localization study they were found to localize to the nucleus and nucleolus. The family also includes other metazoa members from plants to mammals where the protein has been named BR22 and is associated with TTF-1, thyroid transcription factor 1. In the lungs, the family binds TTF-1 to form a complex which influences the expression of the key lung surfactant protein-B (SP-B) and -C (SP-C), the small hydrophobic surfactant proteins that maintain surface tension in alveoli.
Links
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Statistics
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PSSM-Id: 400708
Aligned: 28 rows
Threshold Bit Score: 65.0205
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001524784               6 HSKKRFTnrKET--KTADIKRALTHRA---RLRKNYFKLLKSEGLEEHEKlnleADKRSNDEDESGDSHDDSASDEEVgd 80 
WGS:AAFB:cds.EHI_140020A  33 KTKEKIEqlKQMkkNEKKIEKLIAENAnpnSFYDKYFKGELDDEMEEENNvgfkELIKNQEKQQTKKTIQQARE------ 106
XP_002597411              14 KGRQGFAd---------------RRKK---KVMYEYRKLLNKERKKKGGTaaaaATGSAGVEEGYTEQKGDGNTQAGGee 75 
XP_001607665              28 FNKKKYRe-QKYsnKFKVNQWEEKRKK---AILKGFYKDLKKEEKAANFKfsrkSNSENPEDDNSESSSKKAK------- 96 
EFN84662                  28 FDKKKYRl-KKYsnKYKINQWEERRKK---TVLRDFHKELKRDQQNSTQAsinsNNTSKDAQE-TSN-SKKA-------- 93 
XP_012061822              28 FDKKKYRl-QKYsnKYKINQWEERRKK---AVLREYYKELKKDQQNSAGTssnlSNTSKNTNE-TSKLKKNS-------- 94 
EFN70173                  23 FDKKKYRl-QKYsnKYKINQWEERRKK---AVLREYYKELKRDQQTSSQIssncA--SKNTNE-MSNSKSKS-------- 87 
BAH71391                  12 FDKKKWRt-KKYsnKQKFQDWDERRKK---AVIRDYYKELNKSGNERP------LDTLNDEDNNLTKQQKRP-------- 73 
EFX88179                  16 FNKKKWRe-TQYshKERVSEWESKRKE---AVKRKYRKMLKKDESTSSvq--ttYQLYNAEEGNVNGYSEPPRQRL---- 85 
CCE87048                  11 NTRFSYKdrHEL--KSKEIKKSLTHRA---TLRRKYFKMLENEGLSSNAGeakeREGASGDHESEEASLSEKPEHGESre 85 

XP_001524784              81 kehteklisknkkhsisskqkpLNFAERAAIAKQRKEEQRKAKLAQVQEKLQHI---EKQQKIRELKKQQLKQKTKYGQP 157
WGS:AAFB:cds.EHI_140020A 107 --------------------------ERKEIIKEKKKELEEQKLNQLER--------EKRKKEKLKEKKILLQKTKKGQP 152
XP_002597411              76 qkrf------------kkkppvTAFSRQQQEFKKKQAEKEQRIKEAEQRKEDRIkaaAKHNKERWKRHVQLGKKNKKGQP 143
XP_001607665              97 ----------------------IPFFSAKQEYLKKKQEKDRKKEELLKAQEERKkalEKYKEKKMQTYKQLSKKTKKGQP 154
EFN84662                  94 ----------------------YAFHKAKQKYQETKKEKERKKQETVRIKSEREealKRYKEKKMQTFKVLSKKTKKGQP 151
XP_012061822              95 -----------------------AFFKAKREYRRKQEEKKNRLENAIRVKTEREealKKYREKKLQNYKVLSKKTKKGQP 151
EFN70173                  88 ----------------------YAFYKAKQEYKRKQEEKKKRIQDMIRVKAEREealKKYKEKKLHNFKMLSKKTKKGQP 145
BAH71391                  74 ----------------------NPHKEAQERYNQIQEEKKARRFEASKKKEEIRqalEEYKQKKKLKNKKLGKKTRKGQP 131
EFX88179                  86 ----------------------SEFQRAKLEYERIQGLKEEARLEREQKIKEREiaiMKSKQMRLERIKKLTQKTKKGQP 143
CCE87048                  86 hearekt-------nvkqtkkaLPYIERAKKVKELKEKRRQEKLKQIRDQLKAS---ESKTLQRQKEKEILSQKTKRGQP 155

XP_001524784             158 VMGPRINNLLDKIKRD 173
WGS:AAFB:cds.EHI_140020A 153 IMNNIMNKLLKDIEHq 168
XP_002597411             144 VMANRIEFLLNKIQKE 159
XP_001607665             155 VMKGRMELLLEKIQQS 170
EFN84662                 152 IMKGRIEMLLEKIQQs 167
XP_012061822             152 VMKGRIEMLLEKIQQi 167
EFN70173                 146 VMRGRIEMLLEKIQQs 161
BAH71391                 132 VMKERLELLLEKIQAs 147
EFX88179                 144 VMKGRIEILLQKIQKQ 159
CCE87048                 156 LMGPRINNLLDKIRKD 171
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