Conserved Protein Domain Family
mRING-H2-C3DHC3_ZFPL1
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cd16487: mRING-H2-C3DHC3_ZFPL1 
Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins
ZFPL1, also known as zinc finger protein MCG4, is a novel mitotic Golgi phosphoprotein required for cis-Golgi integrity and efficient endoplasmic reticulum (ER)-to-Golgi transport via directly interacting with the cis-Golgi matrix protein GM130. ZFPL1 is a widely expressed integral membrane protein with two predicted zinc fingers at its N-terminus. One is a novel type of zinc finger, and the other is a modified RING-H2 finger that lacks the fourth zinc-binding residue of the consensus C3H2C3-type RING-H2 finger. It also contains a bipartite nuclear localization signal (NLS), and a leucine zipper at the C-terminus.
Links
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Statistics
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PSSM-Id: 438150
Aligned: 19 rows
Threshold Bit Score: 83.887
Created: 19-Oct-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C [HD] H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:modified RING-H2 finger (C3DHC3-type)
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique cross-brace arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #                # #  #  #                     #   #      
O95159        50 NPNCRLCNIPLa---sRETTRLVCYDLFHWACLNERAaq---lPRNTAPAGYQCPS-CNGPIFP 106 human
XP_013398398  85 NPVCTLCQRSLadedaGNCVRLLCYDVFHWSCLNAYAqq---lPANTAPAGYQCPA-CKTGIFP 144 Lingula anatina
CAM91776      13 DPMCQLCKTDLssedsGDCVRLVCYDVFHWKCLDKYArg---fPANTAPAGYTCPS-CKSCIFL 72  Dumeril's clam worm
KPM07232      51 DSKCQICSMNFnm--eSGCVRLCCYHLFHLNCLNSYAnr---mPANTAPAGYTCPI-CSKPIFS 108 Sarcoptes scabiei
EFX86665      50 SSLCTLCSTDLs---qDDCIRLICYHVFHLKCLDAYCrq---yPVNTAPAGYVCPSpCSHPIFP 107 common water flea
NP_001071883  50 IPNCQLCDGSLl---eGEVVRLLCYDVFHISCLEKHFrn---lPLNTAPAGYRCPA-CETKIFP 106 vase tunicate
XP_004349423  48 SADCVLCNQSLe---nGGVVRLTCYDVLHWECLDKYAks---lPAHTAPAGYTCPQ-CQAPIIP 104 Capsaspora owczarzaki ATCC 30864
NP_732721     50 ISNCTLCGTTLe---qGDCVRLVCYHVFHWDCLNARQaa---lPANTAPRGHQCPA-CSVEIFP 106 fruit fly
Q551M4        49 DSVCGVCKGKFdvddnDDSVRLLCYHLYHPECIDVYVaa---lPQNSSVESYPCPK-CPEPILP 108 Dictyostelium discoideum
XP_003387627  50 ESVCLLCAKSLd---yGDVVRLCCHDLFHVSCLDGYVqsatghSKSYLPSELKCPQ-CKDCLFP 109 Amphimedon queenslandica

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