Conserved Protein Domain Family
UQCC2_CBP6

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pfam20180: UQCC2_CBP6 
Complex III assembly factor UQCC2/CBP6
This family represents mitochondrial respiratory chain complex III (or cytochrome b-c1 complex) assembly factors, including Cbp6 from yeast and its human orthologue UQCC2 (Ubiquinol-Cytochrome c Reductase Complex Assembly Factor 2). These proteins have diverged significantly among eukaryotes and UQCC2/Cbp6 have an overall low amino acid conservation. UQCC2 interacts with UQCC1, the human orthologue of the Cbp6 binding partner Cbp3, to form a complex necessary for cytochrome b biogenesis. Cbp3-Cbp6 complex interacts with mitochondrial ribosomes for efficient translation of cytochrome b transcript and it also interacts with newly synthesized cytochrome b to assist its correct assembly. These proteins contain a LRY-like N-terminal sequence being related to the LYR superfamily of proteins, which function as subunits or assembly factors for respiratory complexes I, II, III, and V.
Statistics
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PSSM-Id: 466331
Aligned: 178 rows
Threshold Bit Score: 46.9317
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
OAK95286        6 TRQYARLLTLWPKDAFRPNLPFTRVIEHRGqpyglkplepaesTPkqaqapaatpapasPPNPQAEQAQVNALFSLLENR 85  
KZS15876       63 FRKVTLLLSKWPLDLSKKGRDIGEHLRHKVainf-----pqgeTS--------------KVHVQEWSNFVEHLGNIANNK 123 
EFX77031        6 YRSVTMLLSRWPLDVSKKGRDIGEHIRHKVassf-----thgeAS--------------KVDIQQWSKFIEHLGNIANNK 66  
RZC40781        6 RTRFLQLLEKWPIEESKVGRDLGQFLRNKInktck----enynFQ---------------TTYWYWERQYLAVQTLVNNE 66  
SPP83788        5 YQKFLKVLEKWPADKTKIGRDLGEQIRKQVtrfsn----glnsEA-----------------DKDLDRQIDALERLSSNV 63  
TDG43713        5 YKRFLNVLEKWPAEKTKVGRDLGEQIRKQAarlkd----assqNS---------------AAAEQLNRQIDALERLSNNV 65  
EDV91290        5 YQRFLKVLEKWPAEQTKVGRDLGEQIRKQVtrltd----asslSN---------------EKTAELNRQIDALERLSKNV 65  
QJC18459        5 YQRFLKVLEKWPAEKSKVGRDLGEQIRKQVtklts----leggAT-----------------DKELDRQINSLERLSNNV 63  
CRL06151        5 YKKFLRLLEKWPVDKTKQGRDLGQHLRTSLeqilg----gkniVA---------------VNNPKLDKQFQSLENLANNI 65  
XP_001864654 1034 YNRFLKLLERWPVDQSKIGRDLGQYLRDQLkavlg----gtniIA---------------VKDERLVRQHQSLENIVNDV 1094
OAK95286       86 YSKKYPLsaDvlkptaapEHYDLLMAE 112 
KZS15876      124 SLTNHPR--Il------kSSATGLSVE 142 
EFX77031       67 SLIKHPR--Tl------kSTATGLSVE 85  
RZC40781       67 HKNKYPR--Vl------tSSATGLTAE 85  
SPP83788       64 YAKKYPR--Sy------eSTATGLTAA 82  
TDG43713       66 YAKKYTR--Rf------eSTATGLTAA 84  
EDV91290       66 YAKKYPR--Ry------eSTATGLTAA 84  
QJC18459       64 YAKKYPR--Tf------eSTATGLTAA 82  
CRL06151       66 YQQKYPP--Kr------kNSRTMLL-R 83  
XP_001864654 1095 HLKAHPR--Sl------nSTATGLSGE 1113
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