Conserved Protein Domain Family
CLPTM1

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pfam05602: CLPTM1 
Cleft lip and palate transmembrane protein 1 (CLPTM1)
This family consists of several eukaryotic cleft lip and palate transmembrane protein 1 sequences. Cleft lip with or without cleft palate is a common birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the human cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.
Statistics
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PSSM-Id: 461689
Aligned: 124 rows
Threshold Bit Score: 344.52
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBN75944      39 AQLFIKLAVLYMSFMFFSkqFQTHqikeavaimkeseqdevsqvlkplpkgeesdvnWMKEAMGlQSSRIPQfpeydarg 118
1_pfamImport   1 TSLIVGVFIVYVLHTCWV--MYGI---------------------------------VHTKSCDs--------------- 30 
Q96KA5         9 TSLVVGVFVVYVVHTCWV--MYGI---------------------------------VYTRPCS----GDAN-------- 41  human
XP_013126123   8 TTLIVGVFVVYVLHTCWV--MYGI---------------------------------VYTKPCS--NPKGAN-------- 42 
Q6DHU1         8 TSLIVGVFLLYVLHTCWV--MYGI---------------------------------VYTKPCE--KRRAES-------- 42  zebrafish
XP_001625137   7 TTIALTVFGLYMLNSVYV--VYNL---------------------------------FYVPSCR-GNS--RE-------- 40 
CAP25397       7 TKIVSTVFLSFMFYNFFQ--LYKL---------------------------------FTPELCA-DTDPDSN-------- 42 
EDV25935       7 GRATVVVFLSYMVYNFYA--LYLL---------------------------------FYPQQCSiVAKNENN-------- 43 
XP_015212343  19 TTLIVGVFVVYVLHTCWV--MYGI---------------------------------VYTKPCE-----KIQ-------- 50  spotted gar
AWO96877      21 AKLLLGVFVVYMLHTAWL--LYGF---------------------------------VNTKPCD-----GDR-------- 52  turbot
CBN75944     119 rqlsVHRCT---F---NRG--QKVDLHVYMS--GsEDEasvwetqgEEAGergagpegeegTANslpaRLLWHESNL-VF 187
1_pfamImport  31 ----NGNCIkpyL---AKK--PKLQSKVQGA--Q-KEDvl-----qESHL------------------SLPSPLEDYmPG 75 
Q96KA5        42 -------CIqpyL---ARR--PKLQLSVYTT--TrSHLg------aENNI------------------DLVLNVEDFdVE 83  human
XP_013126123  43 -------CItpfL---AGN--PKLQLSIYTA--LrSNA--------EGGH------------------TLIHKEENFdVN 82 
Q6DHU1        43 -------CIspyL---AAK--PRLQLSVYT-----ALR--------PNAd-----------GGH----SLIHREEEFdVN 82  zebrafish
XP_001625137  41 -------CLhphS---ILG--QNLELALYTStqPnARS--------IDSL------------------ELLWKKSNFdIF 82 
CAP25397      43 -------CYspiIrpnSEGlfDLLQLRVYFS----TKRd----------------------SLE----TLVTTVENVqIA 85 
EDV25935      44 -------CLrpfL---KDD--AKLSLQIYTSvkStKQS--------IRKL------------------SSIYTEEDF-HY 84 
XP_015212343  51 ----NENCItsyL---AEK--PRLQLSIYTS--L-KPTg-------DGNQ------------------NLIFSMEDFeVF 93  spotted gar
AWO96877      53 ----GEDCItsyL---EAR--PRLQLSVFTC--V-MPE--------NSQL------------------NPAVKIDPFdPH 94  turbot
CBN75944     188 AgEAGDmtrstTLKLDLP-PMlLNNGSAWAHVFLTKKGHSPnpnDPDYKDSGVSHQTAQ-LNRYLPKpkNKDGHYLVDSK 265
1_pfamImport  76 G-SSQR-----IINVTLPkKT-RNNGTLYAYIFLHHAGVLP------WHDSKQVHVVGQ-LTAYMIP--KPEEVNLITGK 139
Q96KA5        84 S-KFER-----TVNVSVPkKT-RNNGTLYAYIFLHHAGVLP------WHDGKQVHLVSP-LTTYMVP--KPEEINLLTGE 147 human
XP_013126123  83 S-KFER-----TINVSLPkKT-RNNGTLYALIFVHQAAHDP------WHDPRQVHSVAQ-LTTYMVP--KPPEISLISGE 146
Q6DHU1        83 T-KFEK-----LVNVSLPkKT-RKNGTLYAMVFLHQAGVSP------WQDPHQVHLVTQ-LTTYMLP--KPPEISLITGQ 146 zebrafish
XP_001625137  83 E-SFTE-----ILNASIPrRT-RNNGSLYVTVYVYPVGQTP------FRNNYMTSYASSaLTTYAVP--KDEVVNLLSGG 147
CAP25397      86 D-AFQK-----ELKVKIPsSV-AKDGYLYAHTILLPHGFED---RNPMSAPWKVHVAAP-MIVFQEP--VAKTFQLLGED 152
EDV25935      85 HkAFTK-----SVNVTLPsAV-VKNGTLFAHIVIYPY-------LQMIDGHSLAYTIAP-LTRYAIP--KADTQHLLSSS 148
XP_015212343  94 S-KFER-----KINVSIPkKT-RNNGTLYAFVFVHKAGVSP------WHDSKQVHHIAQ-LTTYMVP--KPQEINLIIGE 157 spotted gar
AWO96877      95 S-AFER-----QVNVSLPeET-RANGTLHAVVYVHRAGVSP------LEDSREVHYAAQ-LTTYITP-------THTEGK 153 turbot
CBN75944     266 -KSAADAAVekerkel-----dekeaavALAGADRE--MINYWKPTLTLGQLDFTAIFQRNHIPSSFAGHITFQSST--- 334
1_pfamImport 140 -SNFQEEHTkse-------------rkeTKIPNKPV----SHWRARLTLNILADEFIFDGSALPSDVHRYMKIVTQGk-t 200
Q96KA5       148 -SDTQQIEA-------------------EKKPTSALdePVSHWRPRLALNVMADNFVFDGSSLPADVHRYMKMIQLGk-t 206 human
XP_013126123 147 -DKTQGQKEgqqkkphdavpgggaragaTSVSDHPV----SHWRSRLTVNIVGDHFLFDREYLPNDVHRYLRVFQNGk-k 220
Q6DHU1       147 -DEPEKPDQqkq--------------ssDSELDRPV----SHWRSRLTLNVVSENFLFDREALPGDVHRYMRVYQSGk-k 206 zebrafish
XP_001625137 148 -KKSQPIK-----------------------DDLPV----SHWRPTLNFHVMSEKVAFNRYAIPGEIFSLLRYSRMMgkn 199
CAP25397     153 -EAVVEKP---------------------KKAKKVVe-LAAHFRTVLPVRIVSESSRFVKTKVSGELADFLTVQRQD--- 206
EDV25935     149 -IQNRCSSPli----------------iLQTLNRPK----SHWKKTVSVRLMTEKFLFDMKQFPAEIFSLLRLTNGD--- 204
XP_015212343 158 -DTSQQSEPqk---------------ktNGLQDRPV----SHWRSRLTLNVLSEDFAFDREALPSDVHRYMRVIQYGk-r 216 spotted gar
AWO96877     154 kRDPQKrsspr-------------senpV-----------SHWRPHLSVTMMSEEFTFNKAGLPSDVRRYMRVSQDGr-q 208 turbot
CBN75944     335 GNYHPVLYVNEFWLQQKHLLALNSTVESVDLELSISPISLWKFQTMSQLESQWAAQAKIGMAGdGEQDTFRELLAETNPI 414
1_pfamImport 201 VQYLPILFLDLLSNRVKDLMVINGSVTKLPLTISYDTISLGKLRFWIHMQDAVYSLQQFGFTE-KDVDEVKGIFVDTNLY 279
Q96KA5       207 VHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKVSLGRLRFWIHMQDAVYSLQQFGFSE-KDADEVKGIFVDTNLY 285 human
XP_013126123 221 VVYLPLLFVDELSNRVKDLVEINSTTTELPLTISYDSISLGRLRFWIHMQDAVYSLQQFGFTE-KDADEIKGIFVDTNLY 299
Q6DHU1       207 MIYLPLLFVDELSNRVKDLMEINSSSTELPLTITYDSIALGKLRFWIHMQDAVYSLQQFGFTE-KDADEIKGIFVDTNLY 285 zebrafish
XP_001625137 200 EQYLPIVYIDELQVVYRHIQPLNKTSHQMPLNLKYSPISLGKLRIWSAVHQSMGMMKNLGFKD-KDLDEIRGLFTDTNLY 278
CAP25397     207 -QYLPIMFVDEMSMRSKHLFELADFQKSVNLTINYEPTSVAKLLLLTSTARSTQQLMRHGFKD-KDIDELRGLFTETSIV 284
EDV25935     205 -QYLPFLHVTEMSQTLRQAEVIDVNTTVKVLHIDYQPISVGALRFWVSMEESMKLIRKLGFSD-NDIDKVKGIFSSGNLK 282
XP_015212343 217 MLYLPILFIDELSNRVKDLMVINSSTTELPLTISYDTISLGKLRFWIHMQDAVYSLQQFGFTE-KDADEIKGIFVDTNLY 295 spotted gar
AWO96877     209 MIYLPLLLVNELSVRVRDLVEISSSTVHLPLTVSYEGISLRGFRFWVHLQDVVYSLRQFGFTE-ENIDEIKETLVGSNLY 287 turbot
CBN75944     415 VLVITMIVSLLHS-VFNFLAFKNDISFWKDKkRSLEGISVRGMLVNLFFQAVIFLSLADNDTTYMILVTNAIGLAIEVWK 493
1_pfamImport 280 FLALTFFVAAFHL-LFDFLAFKNDISFWKGK-TTMVGMSTKAVLWRCFSTIVIFLFLLDEQTSLLVLVPSGIGALIEVWK 357
Q96KA5       286 FLALTFFVAAFHL-LFDFLAFKNDISFWKKK-KSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLVPAGVGAAIELWK 363 human
XP_013126123 300 FLALTFFVAAFHL-LFDFLAFKNDISFWKQK-KSMVGMSSKAVLWRCFSTIVIFLYLLDEQTSLLVLIPAGIGSMIEVWK 377
Q6DHU1       286 FLALTFFVAAFHL-LFDFLAFKNDISFWKHK-KSMVGMSSKAVLWRCFSTIVIFLYLLDEQTSLLVLVPAGIGSLIEVWK 363 zebrafish
XP_001625137 279 LLGLTFLISIFHL-LFDFLAFKNDVNFWQNA-DSMVGLSSRTVIWRCVCSIIIFLYLMDEKASLLVLFPQGIGSIIEMWK 356
CAP25397     285 LLMITFFVSTLHL-LFDALAFKNDISFWKGR-KSMVGLSTKTLLWRCFSQTIIFFYLFDQETSLLVLIPSGIATVIEYWK 362
EDV25935     283 LLLLTFVISLVHV-LLDFLAFKNDVNFWKGR-KTTAGLSPTTVIWHSFSYSVIFLYLLDEDASYLVIVPLGISTIIEIWK 360
XP_015212343 296 FLALTFFVAAFHMqMFTW-CSCSHFFCFLCQ-----------VLWRCFSTIVIFLYLLDEQTSLLVLIPAGIGSIIEIWK 363 spotted gar
AWO96877     288 LLVLTALITALQL-ICEFLALKNDISSWRKK-KSMVGMSRKSVLWRSLSTLLIFLHLLEE-TSLLVLLPVGMGACVEVWK 364 turbot
CBN75944     494 VGRFMVGRLDWggeDGQprrwVPRMMFqakESYRKS--KTKEFDDVATAHLLYLVGPLMVGYAAYSLLN 560
1_pfamImport 358 VKKAFKMSILW---KGL----KPTFQF---GTYNESekKTEKYDTQAMHFLSYILYPLCIGGAVYSLLY 416
Q96KA5       364 VKKALKMTIFW---RGL----MPEFQF---GTYSESerKTEEYDTQAMKYLSYLLYPLCVGGAVYSLLN 422 human
XP_013126123 378 VKKAFKIQVFW---KGG----KPTFLF---GKLDESerRTEEYDTLAMKYLSYLLYPLCIGGAVYALIF 436
Q6DHU1       364 VKKAFKIHVIW---RGL----TPTFLF---GKLDESekRTEEYDTLAMKYLSYLLYPLCVGGAVYALVF 422 zebrafish
XP_001625137 357 LTKALKVTIIW---RGA----KPTLKF---GERSTQekQTDEFDGEALYYLKYVMYPLVVASAVYSLLY 415
CAP25397     363 VTIAYKVSISW---RGI--------KF---GKHSAEedETDSIDAQAMKYLSILLVPLVIGGAVYSLLY 417
EDV25935     361 LAKVFKVTLERk-pEHW----LPSIQF---GQRSKAeqESESYDLEAIRYLSYFLYPLVLIGAIYCLIY 421
XP_015212343 364 VKKAFKIHVLW---KGL----KPTFQF---GKSDESerKTEEYDTQAMKYLSYLLYPLCIGGAVYSLIY 422 spotted gar
AWO96877     365 VFKVLKIQLQW---KSS------DLHV---TKMDEEerKTVEYDTQASRYLSYLVYPLCISGAIFSLAY 421 turbot
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