Conserved Protein Domain Family
Katanin_con80
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pfam13925: Katanin_con80 
con80 domain of Katanin
The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.
Links
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Statistics
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PSSM-Id: 464044
Aligned: 67 rows
Threshold Bit Score: 89.9792
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002501939 722 PDGGTVSGILTARLTTLTACKNMWVKGDTRGVAETLAKSGDQSAVVDVATAA-LDAPavagghETLTLELAAALTPLMRD 800
CAG03527     108 KDHEAMTHILFGRNLRLKVAQTLWRRSA-SELVAYLIRIQDPGVLLDCLPVLtNDLQge---sPCLSLGCCVDLMPQVKV 183
XP_023204084  46 KDHEAMTHILFGRDLRLKVALTLWRRNA-SELVSYLIRIQDTGVLLDCLPILtNNLQte---aPCLSLGCCVDLLPQVKV 121
XP_004083952 144 KDHEAMTRILFGRDLRLKVALTLWRRSA-CELVAYLTRLQDTRLLIDCLPILtNNLQte---tSCLTLGCCVDLLPQVKG 219
XP_013128394 147 RDHNTLTDVLFGRNLRLKVALTLWQRNV-GELLTYFLRIQDTGVFVDFLPLIsKCIHed---sSKITIGCCVDLFPLVSK 222
XP_014331699 144 KDHSTMSDVLFGRNLRLKVALTLWRRNV-GELLTYFLKIQDIGVIVDFLPIIcKCIDed---sPRINIGCCVDLFPLVRK 219
XP_026689781  13 KEHQVVISVLQTRAMRINAALTFWKSKDFTQLISYLLRTNDDSLFVDILPFLtKSLTenekqkQPVTLGVCLELLPILER 92 
2_pfamImport   1 QGHAVMLSVLQSRTMRLNAALTFWKNDDIIQLISYILRTDDDSLLVDILPFLtQRLAenekhkHAVTLGVCVDLLPVIER 80 
EEN69454     155 SGHPTMTKVLSGRLLWLQAALTFWKQSP-TALVSYILRINNDALLADVIPILiKSIKdgnaigKPISMGACLELLPALQK 233
EDO39116     133 KGHLAMTTVLSSRLLKLRAAETLWHKDTSNGFVEYILRLKDDSVLVDVMPLLtSRVKenapeeHSLSMGACLEMLPALER 212

XP_002501939 801 LLKSPHASYVDLALRFARTVARRFMSLLKSAP---EAMEAvrrgGIGVDLVGEEratrayscvhaLEALRPQLETIDRGG 877
CAG03527     184 IIAGKYEEHIKVGLHWVQSVIRKWWPELSRKEr-rL--QDsrseDRNIEAMKQR-----------LKELWKEGTHICSVP 249
XP_023204084 122 ILSSKYEEHITVALRWVQSVIRKWWPELSKAEk-rL--QDscseDRNVDVMKQR-----------LKDLWKEGSRLCLVS 187
XP_004083952 220 LLLSRYEEHIVVGLRWLQAVIRKWWAELSEKE---RRLQDpcseHRNVEVMRMR-----------LKDLQKEGTRLCSLP 285
XP_013128394 223 VLSSPYEEHLTVGLKWVNSVLKNWWEDLKASGfsgSTNPLl---DENFQVFNQQ-----------LWELWQQEPFLKSVP 288
XP_014331699 220 VLSTPYEEYLIVGFKWICSVLKNWWVELQTSGy-nG--STqpllDENFQVFNQQ-----------LWELWQQEPLLKSVT 285
XP_026689781  93 LLTKKYEEYVVVSLDLIRTMMKTWYRELYNMKq-hEN-NLplnsSLSLPPIYVK-----------LMSLNELVERLSKKS 159
2_pfamImport  81 LLKKKYEDYVVVSLDFIRTIVKTWYRELSNMKn-sRN-YQslnaSLNLPPVYSS-----------LLSLHDLIQRLANKS 147
EEN69454     234 MLTSKYEDYISGSLDLIRTILKHWWKDLKSLQa-sQQNLRlglrSRSVNGVYTS-----------IVAMTDTLQKIAKRP 301
EDO39116     213 LLASKYEDYIVAALNMMREMIKRWWNQLKAASs-kDTDPEhfrySRSVNGLYMA-----------MVSISAIVARLKKRR 280

XP_002501939 878 GELAPRAREMRGLL 891
CAG03527     250 GPTGEQAKAIEASL 263
XP_023204084 188 GSVGELANTIDSHL 201
XP_004083952 286 GSSGDLAKAVAAHL 299
XP_013128394 289 GPAGDMAKVIDSFL 302
XP_014331699 286 GQAENMAKVVESYL 299
XP_026689781 160 GTTATKAKVVHEIL 173
2_pfamImport 148 GPVATKAKVVHEML 161
EEN69454     302 GNIGQKAQCLMASL 315
EDO39116     281 GIVGQKAQIVSRLL 294
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