Conserved Protein Domain Family
Mitofilin

?
pfam09731: Mitofilin 
Mitochondrial inner membrane protein
Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.
Statistics
?
PSSM-Id: 430783
Aligned: 17 rows
Threshold Bit Score: 352.907
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q6PFS4        39 GSSAGKiva---aslLTVGGGLGGTILYAKWDPKFRSSIEKS-VPYSDQLFDMVLGAPPsppvpi----------qkkpe 104 zebrafish
Q55BP9        65 PFGFKP---------LIALVLVGGISAYLYKAWDNQDFMFSSkLPYQREEVEKFKKIMK--------------------- 114 Dictyostelium d...
Q2HCU4       115 KGFFRRlrnffltltLLSALGFGGGVWYSRINDNFHDFFTEY-IPYGEQAVLYLEEMD---------------------- 171 Chaetomium glob...
Q5K8K8        77 PRRFRRvfv---ytaLGVAGFYALSGYVGTKSDAYRDLFTQY-VPGGEAVADYADDNDWd-------------------- 132 Cryptococcus ne...
KIS72220      40 RSGLGRlfv---ystVGATVFYGISTVAALNNDRYNHFFVES-IPGGERIIDYLDTHDVgqeiksinlhgygdkaidvtk 115
P91928        68 EAGFGKvv-----lfVSPLAAVGGVITYAKYDDDFRKLVEKN-VPGAGSVIKVALQEEPpfkgitknvndqidkvksgie 141 fruit fly
1_pfamImport   1 EAGFGKvl-----vvLSPILIGGGVVTYAKYDNEFRKTLITN-VPALEPVLKTLLQETNpldev-----------skkmd 63 
DAA24582      40 rlSASKiag---agiLFVGGGIGGTILYAKWDSHFRKNVEKT-IPYSDKLFEMVLGSPPytvpl-----------pkkpi 104
NP_001006462  41 gVSVGKiig---asvLFVGGGVGGTVLYASYDPRFRENVEKA-IPYSDKLFEMALGPAPysvpi-----------pkkpv 105
Q9XXN2        20 SSGGLKfvg---atvGAVTAGAAGVAGYASYDNEFRKKLEGV-IPGSRTILNYTIGEEEppap--------------rlk 81  Caenorhabditis ...
Q6PFS4       105 TVKPLQISSLSEATKDSKQPKAKAKKSDpapppsveeapapa---palqsleeasaeaAHI-ISAISEVPSVPAPGTSDE 180 zebrafish
Q55BP9       115 EIHQDSQRENLNIEKESKESKESDQQQQh-----------------------------QQQ-QQQQHHQQEEEKEEEKVG 164 Dictyostelium d...
Q2HCU4       172 -FKKRSLTWLAGWETAG------------------------------------------RQ-SSAVQKVAAAKEPSKKAE 207 Chaetomium glob...
Q5K8K8       133 NVSGKAVRAWQSITGARPETRTEKVERKi---------------------------------GEVRQEAAKVPAQVKDKA 179 Cryptococcus ne...
KIS72220     116 TAYDSVSGAVSRVFSGDAGASESAGDERd------------------------------AR-LRVSEARATAKAEADKLA 164
P91928       142 TVTSTVDSVTSKVTGLFGGGSGDDKSKKskvepv------------------katpaeEKR-PSKPSEVSKTEAKPVSKP 202 fruit fly
1_pfamImport  64 DISKTIGEYTSTITGFFGGGDEEKKQEKkpdlppitraksvhvpvpspplpkpepinlSDKvPEQPKKKPEAAAPKVTTA 143
DAA24582     105 QSGPLKISSVSEVMKESKQPASQPQKQKgdtsasttagdt------lsvpapvvqheeLIK-TDHPETGEGKPKPATSEE 177
NP_001006462 106 QQGPLKISSVAEVMKESKQPVPKPQ-------------------------------------TSKTEAVAPSEEKEDKEH 148
Q9XXN2        82 DLRPLQYSADPKVPPKPFEPKPVKKELIg-----------------------------VKEnLKETTEPKKIEKKPENPY 132 Caenorhabditis ...
Q6PFS4       181 SPSGHsaaaeecckectepepavkerpaeevtarlaQQDKAELDALAALTAGLEETLGSSAKVTLQAIGAQEAALTAIAA 260 zebrafish
Q55BP9       165 VENTT-------------------------------LEDNIIESIKNHEEEMKNELVSLIESVQDKYAHSNDDEINADER 213 Dictyostelium d...
Q2HCU4       208 PVVV---------------------------------APPKEEAPKVPAPEVKAEEPKKPAPAPAAE------KKRPSKK 248 Chaetomium glob...
Q5K8K8       180 DEAKDhv----------------------------vGKHTASQKIHERAEELRKAVEQKTHEAEARLKELTGEAKHKVQE 231 Cryptococcus ne...
KIS72220     165 QRAKV-------------------------------AAEKAEHQAESALQAVQDKTSELVNRAKAAAERAEAKVRGQTTE 213
P91928       203 AAAAApapaa---------------------kpkdnPLPRDVVELEKAIELSAQLAVKEYNVAIGVLKGFNDDVRKVVDK 261 fruit fly
1_pfamImport 144 TATKAaaaataaapaksap---aapskpaplasggeTVPKSISDLEQQVEVAATIAIKEYGHAVDVLKSYTNEVRKVVDE 220
DAA24582     178 ASSTSvrerppe-----------------evaarlaQQEKQEQVKIESLAKSLEDALSQTARITQQAIVAQNAAVQAVTA 240
NP_001006462 149 EGSHAikerspd-----------------evaarlaQQDKEEQEKISALAATLEGALSSTARITLQAITAQESAVQAVNA 211
Q9XXN2       133 IGAK---------------------------------TPLNPQERNEKLTESLKNHLTQAEKATKVATSAKLETIRAIEH 179 Caenorhabditis ...
Q6PFS4       261 HTDKLREAMDSETPPDEKSTQalnealneraravddagea--------lfkakgeleklrsvidkaKQSKIDSARPQILA 332 zebrafish
Q55BP9       214 EMDSETGVSISDEISKLIEEH---------------------------------------------KQNEEESLPDLLDV 248 Dictyostelium d...
Q2HCU4       249 VTEKKAVENKPVEKQPEPETSlvpa-------------------------------------ttalTPAQKAFKAPEVDE 291 Chaetomium glob...
Q5K8K8       232 ATKDAPFNFSEGVEGIVRAAEsalhktehkaaeaadkvkpaearpsspfpdtqrprelkpetvtpqVPSYEGKKLYTGPP 311 Cryptococcus ne...
KIS72220     214 ASKDGRNIIQRAVDSVQVMTDigantkaapsksaap---------------gngpkeevketyigeLPVNHEAPVGYAAP 278
P91928       262 AVENGENSLWTTLKNRASARDtavataeraa-------------------------reaqekivacEIALSAAATAQNAK 316 fruit fly
1_pfamImport 221 SVDKLDSSSWTTLRNRTSARDtalqaaedaadk---------------------argnieklhallNSREIKCSDELKDK 279
DAA24582     241 HANILKAAMDDSEIAGDKKSAqwrtvegalkerrkavdeaa-----dallkakeelekmksvienaKKEEVAGAKSHITA 315
NP_001006462 212 HLQILKEAMDDSETAGEKKSAqwrtleealkdrrravdeaa-----dvllkakeelektkgvienaKKSQIPGAKSHIIA 286
Q9XXN2       180 HVQTIREAIEAGKDGDWDSVTvahlkakrlaekdekae-----------klarnavadlvteanlgGQGETTQLNPLVPI 248 Caenorhabditis ...
Q6PFS4       333 AEEN----------LHSMIVDLDKVVTKVQTAqseakivsqYSELVNEAKAQFQQELANITPEIQANWKGLSGkLSADDL 402 zebrafish
Q55BP9       249 NYGV----------LSIIPEAVKSAEETVENA---------LKKFTHSNDDDDDTTTTSIIINTSDELKNHNInIENGNE 309 Dictyostelium d...
Q2HCU4       292 PSRW----------PPASPid-------------------pLAVPNAADPVV--QDLVRMLNDIITVINHDGA---NDRY 337 Chaetomium glob...
Q5K8K8       312 LPLGhepppgyylpPPPSTKKEKVEEKVEEIKerlpllvpkVKEFASEEPII--SQLASTIDSLTSSLSTPSK-ALSSDA 388 Cryptococcus ne...
KIS72220     279 RRDR----------GLQAPDHPTARLRPDPEApklpllapsIKSLSASEPMI--AQLAGTIDELTVFLKETPS--SGAKA 344
P91928       317 KVEAvr------dkIKKLVDHIGNVKDELYRHkdtasvsdkYWRNVEKARNYFIDEIESIFPGLSLADKKLNL--SKEDL 388 fruit fly
1_pfamImport 280 ARQN----------IAAYLDHLKKAKEEVYAArdlaslgekYWKRVESARNYFVEEMESLFPGI--NLAERKLnLSKDEL 347
DAA24582     316 AEGK----------LHNMIIDLDNVVQKVQAAqseakvvsqYHELVVQAREDFKRELDSITPEVLPGWKGMTDkLSADDL 385
NP_001006462 287 AEEN----------LHHMIVDLDNVVKKVQAAqseakivaqYHELVATAREEFQRELDSITPDVQPGWKGLTGqLSTDDL 356
Q9XXN2       249 SKAT----------AEKLSNELDEMISNVKHVdserifvhdYSDRVAESRRKFQMELKAVHPNLN---YEDGMkIKKADL 315 Caenorhabditis ...
Q6PFS4       403 NSLIAHAHRRIDQLNReLAEQRVREQIHIEVALEQQKLEdQKAQERAVISALEHSRE------DMRLEQEKKVQEVREVM 476 zebrafish
Q55BP9       310 ESLVDSLDVNYNVLSI-IPEKVKSAEEKVENVLKKFEEQyLEKVEKLISENMKLKVDfdklinGKDDELKRVEEEIREKY 388 Dictyostelium d...
Q2HCU4       338 GATIGKAKNEISKVGQkILDIKTAVEKDAAQQVRQRVDG-FDQAANDLVARLEAAMTvq--eqQFRREFEAEMERLRKSY 414 Chaetomium glob...
Q5K8K8       389 TGILNKAQDDLTALNArLQEVKKAEKAKLEQSISEKKKE-----FEALLKSMEAEKAks--eeGLKQTWQHERQTMVEDW 461 Cryptococcus ne...
KIS72220     345 KGVLESAQIDLEQLSQrLETIKRQEAKRVEDSLAAQAKR-YETQISKQSQEAADKLSsr--esDWQKSFEEEHAKQTQQF 421
P91928       389 DLFILHAYTHVLAYQKeLQRLQTDGELRLKRAIDSVR---GDNDSEALRAQLEYHLEae--rrKLAVENQKKIFHIHAES 463 fruit fly
1_pfamImport 348 DLFILHAYTQVIAHQKeLQKLQIEGDQNLRRALEAVR---GSDQSEEVKARLEYEIAke--krQLNLLNQKKLLLTRAEL 422
DAA24582     386 NALIAHAHRRIDQLNRaLAEQKATEKQHIALALEKQKLEeKRAFDSAVAKALEHHRS------EIQAEQDRKVEEVRDAM 459
NP_001006462 357 NSLIAHAHRRIDQLNKeLAEQRVREQQHIELALEKQKLEdKKALEAAVAKALEHHKS------EIEIEQEKKVEEVREVM 430
Q9XXN2       316 HTILAHAHLRIDQLSQkLIDSKLNEEKRIQSIIAKKKEDlLEKLRLETNAKQAAVIPefd-kkKLDAELARATAEIQKKY 394 Caenorhabditis ...
Q6PFS4       477 EAEMRTQLRRQAAAHTDHLRDVlkvqeqelreeaQEILNSKMMEQEthyrrltqeqlDTFTLDMNAAYAR-LKGIEEAID 555 zebrafish
Q55BP9       389 RSSLDAAIEELNKDLDEKLKDM------------DQFIKSKVFDNQ-----------AVLQETLEKQKSNlINIFKQQAE 445 Dictyostelium d...
Q2HCU4       415 DNKVHLIQERERQLAEEKLNNQlleqavqlqrafTQDIKKHVEQER-----------DGRLGKLNELKAA-VEGLEKLTA 482 Chaetomium glob...
Q5K8K8       462 RKELEGELEQQRQSIEQRLREEvvsqgielqrrwLRSIKTQVETER-----------GGRLAKLDSLTTS-LKQLERITL 529 Cryptococcus ne...
KIS72220     422 KEKLEKELATQSQIINERLKEEviaqgielqrrwMKDIKAKVEEER-----------GGRLSKLDELATD-LKSLEKVSL 489
P91928       464 DKLLRLQLKKQAEAHADHIKDIvaqretdltrsfKRELEDKLATEK-----------ANYKLQLAGMLGK-LRGMDAALA 531 fruit fly
1_pfamImport 423 EQQMREQLKRQTEAHVDHLKDAltqkelemkrkfQRELDEKITTEQ-----------ASYKLQLAAMLGK-LKGIHNALV 490
DAA24582     460 ENEMRTQLRRQAAAHTDHLRDVlrvqeqelkyefEQDLSEKLAEQElqfrrlsqeqvDNFTLDINTAYAR-LRGIEQAVQ 538
NP_001006462 431 ESEMRTQLRRQAAAHTDHLRDVlkiqeqelkvefEQNLSEKLSEQEmqfrrltqeqlDNFTLDINTAYAR-LKGIEQAVE 509
Q9XXN2       395 DEKLK---------------EVvrtqkqlydiehAKDVDEAVLKER-----------NLHSSAVGKALAQ-LAGIEKALS 447 Caenorhabditis ...
Q6PFS4       556 SHVIAEEEARKAHQLWLSVEALNYTLKSAGADS-----PTEPLEGAVRAIKES-----CAENEFAQALAIAIPEESLNR- 624 zebrafish
Q55BP9       446 SIKQSELEKRAITQLTQCIVDLQKLLHDKSAIDga--nGKGLLVRSFKNLTDL-----SNYDQLIKELLSTLPEGFEKK- 517 Dictyostelium d...
Q2HCU4       483 GWNEVIDANLRTQQLHVAVEAVRASLEDAHH--------PRPFIKELVALKEI-----AAQDPVVDAAIASVHPSAYQR- 548 Chaetomium glob...
Q5K8K8       530 DNSATLDDNVRLHKIWSALRAVQSKVDSGD----------LAFDDELRALKSLstptaSSGEGVVRSALEQIEKSGIPQt 599 Cryptococcus ne...
KIS72220     490 DNSSVLDENLSVHTLWTAVRAVQHALDDASATK-------RPFAEQLRVLKGTs---kARDDPVLSAAIEALDASGAADt 559
P91928       532 ERADAERTANQAQALWAACQALWASVRAATPGVhy-kdRLRPLKNEINAIAKV-----AKGDDLVAAVLESVPKEAQER- 604 fruit fly
1_pfamImport 491 EHADAEKSAHQAQALWGACQSLWSSIRSGQPGKsw-rdQLRPLKDEIAAVARS-----AEGDELVTVVLKGLPETAVKR- 563
DAA24582     539 SHAVAEEEARKVHQLWLSVEALRYRMKTASADL-----PTVPLGSAVEAIRAS-----CSDSEFAQALTAALPPESLTR- 607
NP_001006462 510 SHAVAEEEARKAHQLWLSVEALKYCMKTASGDS-----PTEPLESAVKAIKAS-----CSDNAFTEALTAALPQESLTR- 578
Q9XXN2       448 GHLQMDIENRKSKQMWLATQNLKGTVIFGNRASccmegRRAPLGDQMKTLLSCcg--gGNSDEFVKTINTAMSKTSKVR- 524 Caenorhabditis ...
Q6PFS4       625 GIYSEASLRARF-YDIRRLARRVALI-DETRNSLYQYFLSYLQSVLLFERDQeapp-----aklAPEDLDTFKLLAYATY 697 zebrafish
Q55BP9       518 PVIPLDTLNNQF-QDIAKKLRKSQLI-DPNDNSLLGKAVSELASLFIIPEKG------------MVQGNDYDAILARAED 583 Dictyostelium d...
Q2HCU4       549 GISTPAELIDRF-RRVAAEVRKASLL--PDDAGVASHASSYVLSKVMFK-KQgl-----------aAGDDVESILTRTQT 613 Chaetomium glob...
Q5K8K8       600 GVKSFAALSSWFtNTVAPRIQSSSLVpAPEEATVISHLASAGLSKIMFRPQAgr-----------vPGDSVGAVLARAEW 668 Cryptococcus ne...
KIS72220     560 GVETFTTLKQWFdDKVGPRVRQVSLVpSPETSGVLSHLASAALSPILFH-KKgl-----------vPGQDVPSVLARAEY 627
P91928       605 GVYPEDALRERF-LNVERVARRLALV-PEEGAGLPIYFLSYLQSLFILRPDNpiskdelenkpfDYSKLDTYDILNRARY 682 fruit fly
1_pfamImport 564 GVYPEDALRERF-LKVEEVSRRLALV-PAEGARLPMYVLSYLQAALIARPDKpisqdelenkpfDFSKLDTYDILNRARY 641
DAA24582     608 GVYSEETLRVRF-YAVQKLARRVAMI-DETRNSLYQYFLSYLQSLLLFPPQQlkpp-----aelCPEDADTFTLLSYASY 680
NP_001006462 579 GVYSEEALRARF-YTVQKLAKRVAMI-DETRNSLYQYFLSYLQSLLVFHPQQlkpp-----aelSPDDLDTFKLLSYASY 651
Q9XXN2       525 GEYTEQDLNTRF-NKVCRIGRRVAYV---NEGGALAHLYSWLKSSLTIELVPkkga----neslTPAVENNFTLLTRAEQ 596 Caenorhabditis ...
Q6PFS4       698 SIERGDLELAAKFVNQLRG-ESQ-----------RVAQDWLKEARLTLETKQVISLLsaYAN 747 zebrafish
Q55BP9       584 HLRKNNLSSAIKEMESIQQqSSKsstnidnhhlsKLTSNWIKQAKERDQLENISKLL--ELK 643 Dictyostelium discoideum AX4
Q2HCU4       614 FLEEGDLDNAAREMNGLTG-WSK-----------TLSRDWLGEVRKVLEVRQALEVIqtEAR 663 Chaetomium globosum CBS 148.51
Q5K8K8       669 CLAEKDLDGAAREINSLTG-WPA-----------KLANDWLQQARRKLEVQQALEVVatEAT 718 Cryptococcus neoformans
KIS72220     628 YLDRKDLDSATRELNQLKG-WPK-----------LLASDWLAASRKRLEVQQALDVVqtEAS 677
P91928       683 HVDRSDFLQALKYMNLLQG-ASR-----------KIAGEWMKEARLMLETQQAANTLmaHAA 732 fruit fly
1_pfamImport 642 WLDRGDLVKTVQYVNLLQG-APR-----------KAALDWLNEARLLLETQQAASTLmaHAA 691
DAA24582     681 CLEHGDLELAAKFVNQLKG-ESR-----------RAAQGWLKEARVTLETRQIVEILtaYAS 730
NP_001006462 652 CIEHGDLELAAKFVNQLRG-ESR-----------RVAHDWLTEARMTLETKQIVDILtaYAS 701
Q9XXN2       597 LWKSGKKSDAIRVLQLTDG-ATR-----------RVAADFIADARRQHEALLLSRLLlaHAA 646 Caenorhabditis elegans
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap