Conserved Protein Domain Family
CIA30

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pfam08547: CIA30 
Complex I intermediate-associated protein 30 (CIA30)
This protein is associated with mitochondrial Complex I intermediate-associated protein 30 (CIA30) in human and mouse. The family is also present in Schizosaccharomyces pombe which does not contain the NADH dehydrogenase component of complex I, or many of the other essential subunits. This means it is possible that this family of protein may not be directly involved in oxidative phosphorylation.
Statistics
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PSSM-Id: 462515
Aligned: 53 rows
Threshold Bit Score: 122.701
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5B0J2     8 FSFLDSitvkgfTtelttttrspwLSADWTSTDDRVRG-GSSHSYLIPSh---------------------dG-KTATFN 64  Aspergillus nidulans
Q9VAI1    92 FDFKAP------D-----------VLDKWTVTTDADHGeGKSTATLELSaag------------------agL-----FH 131 fruit fly
Q61FQ3   137 YKFDTS------E-----------KLDLWKIGCDSDWKeGFSTCSLVNSdrg------------------taV-----FS 176 Caenorhabditis brig...
Q0V6I3    43 IHFEQP------E-----------DIARCKRMSDKDIG-GFSTANLDYHpvt-----------------qteP-AHARFH 86  Parastagonospora no...
Q2H444   125 HNFRSP------T-----------SIQDCKLMSDVEIG-GFSKANLDWIpsppassd-------iqrpspnsL-GYAKFH 178 Chaetomium globosum...
O42636    43 HNFQTP------E-----------SVADCKLLSDADVG-GSSTAHLDWVpppnaiptvtagdgsdrkpytpiPgSYARFH 104 Neurospora crassa O...
Q6C935    19 VNFTKP------N-----------SLETVLTKCDEELG-GYSTVNLALErpt-----------------tgkP--YGRFF 61  Yarrowia lipolytica
EDK43256  58 LDFSH-------YhqttttpdqldTVPNILTRSDKEIG-GYSNVNFKIDp---------------------vE-KCAHFY 107
Q6BIV3    30 LDFKNN------Aq---------tSLDSIMTRCDQEMG-GFSSVNFNVdp---------------------vS-KAGHFY 71  Debaryomyces hansenii
EAZ63751  31 LDFKQ-------Hgd--------eSLNNVMTRSDKEMG-GYSTVHFELDd---------------------kE-HVGHFH 72 
Q5B0J2    65 GHLDTRt------lGGAGFASQRTt--------GDRSWDLSSYSGVELDIDtanSDTKLYTLIVKDEkgllpprddgrer 130 Aspergillus nidulans
Q9VAI1   132 GQVNSDhtkd-giiKRTGYANIRTkrvr-ksfkRETTYDWTQYNMLVMKVR---GDGRSYLINLHTEgyf-------dlm 199 fruit fly
Q61FQ3   177 GNISTRvlkd-grvERAGWASMKLedrk-tfnrKKFLSKWRNFSHLLLKVR---GDGRSYKIMLHSPlsm-------dft 244 Caenorhabditis brig...
Q0V6I3    87 GKISTQlpqnqphiQRTGYAGWRTldrg-atifGKSLWDVERYNFIAIQFK---SDGRKYFVNVQTEsi----------v 152 Parastagonospora no...
Q2H444   179 GNISTElppdrpdiKRTGYAAFRTrdrp-ptifGRSLYNIDPYVYLALRVK---SDGRSYFINVQTEsv----------v 244 Chaetomium globosum...
O42636   105 GTISLElptdrreiSRTGYAGFRTldrp-ptifGRGLWDIDPYAYLAMRVK---TDARSYFVNVRTEsv----------v 170 Neurospora crassa O...
Q6C935    62 GNLSLDlpkdnkmvTRSGFAMFRTldqp-ssmfKTNAWNWEQYRHLELRVR---GDRRKYFVNVQSAtp----------l 127 Yarrowia lipolytica
EDK43256 108 GDLNLDlpkdnpqvTRSGYAMFRTrdqaqswllGENYWDWSDFSALVLRVK---GDRRKYLVNIQANtp----------l 174
Q6BIV3    72 GYLNLDvpkdhpeaTRSGYAMFRTrdqkdswlsGNSYWDWSQYQALVMRIK---GDRRKYLVNIQANtp----------l 138 Debaryomyces hansenii
EAZ63751  73 GYLSLDlpkdnpevTRSGYAMFRTkdqkeswlsGNSYWDWSNYSSLVLRVK---GDRRKYLVNIQTNtp----------l 139
Q5B0J2   131 SGLSWEADFR---PGYnKGKVAFKWEDFRPTYRGKEVhDVEPLDCKAIKRFSIMMRrfvffgdffGE--QEGDFTLSI 203 Aspergillus nidulans
Q9VAI1   200 WNDIYHYVLYt-rGGPhWQIAKIPFSKFFLSSKGRVQdRQGAIPLNRVTHFGFSVA---------AKkgMDGPFGLEI 267 fruit fly
Q61FQ3   245 WGDSFSHPLHt-hGGPyWQYEKIPFSKFFHTVAGRIQdRQYRVNLEDTSSIGIVLM---------DR--IDGDFKLEI 310 Caenorhabditis briggsae
Q0V6I3   153 PTDIHQHLLYsktPGE-WELILIRWAEFVRTNHGQVVePQREMLTQKVRTVGMSLI---------DR--IPGPFDLSI 218 Parastagonospora nodo...
Q2H444   245 PTDLHQHRLFvkkPGE-WETVLIKWNDFVRTNYGFVVePQTEIMRQKVKSIGIGLT---------DR--IPGPFELCI 310 Chaetomium globosum C...
O42636   171 PLDLHQHRLFvkkPGQ-WETVLIKWNDFVRTNHGKVIePQTGMLRQKVLSIGFSTT---------DR--KAGPYELCV 236 Neurospora crassa OR74A
Q6C935   128 ASDLYQHRLFiqtPGE-WETVVIPIDDFILTNKG-VVqEQMAMDTANVYTVGIGLI---------DR--QYGPYNLDI 192 Yarrowia lipolytica
EDK43256 175 VTDLFQHRLFlnhPGQ-WETVVIPLNDFVMTNWG-VIqDNSELNKLEIKTIGIGLL---------DK--QYGPYSLKI 239
Q6BIV3   139 VTDLFQHRLFlhhPGE-WETVVIPLNDFVMTNWG-VIqDGGEMNKSEVKTIGIGLL---------DK--QYGPYSLYV 203 Debaryomyces hansenii
EAZ63751 140 VTDLFQHRLFlnhPGE-WETVVIPLNDFVMTNWG-VIqDGSEINKSEVKTVGIGLL---------DK--QYGPYSLKV 204
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