Conserved Protein Domain Family
Hmw_CFAP97

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pfam13879: Hmw_CFAP97 
Hemingway/CFA97
Drosophila Hemingway (Hmw) is required for motile cilia function and sperm flagella assembly. The human orthologue, known as cilia- and flagella-associated protein 97 (CFAP97) or KIAA1430, localizes to the primary cilium. Another member of this family is the uncharacterized protein CFAP97D1/2 (CFAP97 domain-containing protein 1/2).
Statistics
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PSSM-Id: 464014
Aligned: 87 rows
Threshold Bit Score: 33.8665
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002906998  36 RRIKHAHSV---IDTE---------AgIRTVNNAKKLQQEQ-DREIEIAQ----HNQLLLDRLERIHKKLPKqfDVSHHT 98 
A4IJ15       283 NQLLKAFMH---LDKKepss--vqdE-NPVMHNKKNFSFSN-DEVRQIER----ENQRLLKELTRQAAKPR-----SKSL 346 tropical clawed...
XP_014353280 329 NQLLKAFMQ---LNKKeqkn--lviD-YPSSKSRKNLSFSN-EEVMRIDR----ENQRLLGELARQATKP-------RSK 390
XP_006092737 339 NQLLKAFLE---LDKKrpek--hhlD-QPSAAPRRNYSFTR-EEVRQIDR----ENQRLLKELSRQAEKPG-----SKNM 402
XP_023370668 336 NHLLKAFLQ---LDKKepqk--hhfE-QQLVVPRKNYSFTK-EEVRQIDR----ENQRLLKELSRQAEKPG-----SRST 399
EDS37032      95 FHMDIMKNS---LSDIslhsstrriGsGKPAKATQNLSFSR-ARVREIER----HNQILLQRIMTSKPTLKT--KPKSNA 164
EFX59853      29 LNILAAKSH---LDNRnptn--pkhSpSAPLAL---------LQRKILQQ----DNRGMVSRIMRIAQDK---------P 81 
A0CJ50        28 NQVQNIKEQp--MNVEkp-------------fhKKKLKSSTsKKLLEIKHpentENKILVQKILTINNQP------SSYA 86  Paramecium tetr...
A0C534        35 HQIIKIKATp--VQVDqp-------------ymRKKQVCSL-KKVREDPT----IKKALVSRILEINHCPS-----YYGK 89  Paramecium tetr...
XP_012962316 335 SKMYSEFPAflqLEKKeqqk--itfD-QPPRGTRKNYSFTN-EEVRQIDR----ENQRLLKELSRQSAKP-----RSRST 401 mallard
XP_002906998  99 QEHLGIQSPSNY---------SQWQREQKRIAKENEKMRRRIE 132
A4IJ15       347 TPKKPMSAPTRLyh-----saINRQKEQQRIERENMALLKRLE 384 tropical clawed frog
XP_014353280 391 TPKKSSPQPVKLch-----saINRQREQKRIEQENLAFLKRLE 428
XP_006092737 403 IPRRYS-HPPKLyh-----saVNRQKEQQRIERENLALLKRLE 439
XP_023370668 400 VTRWH--HPPKLyh-----saLNRQREQQRIERENLALLKRLE 435
EDS37032     165 TPINTPVMNNSRits----aaVNRRKKQRQIEIDNQTIapssp 203
EFX59853      82 ALSRTHTELTSLvrnlkayssLNRSMRLRAIEEENCRIFSRLv 124
A0CJ50        87 LNEDLPIKPSNL---------GQKILEMRKLIEDNEGIEKRIK 120 Paramecium tetraurelia
A0C534        90 LDTSDIPRPSNL---------GQKIIDMKRLIEDNESIERRLR 123 Paramecium tetraurelia
XP_012962316 402 TLKKSTLPPPKLyh-----saLNRQKEQQRIERENLAFLKRLE 439 mallard
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