Conserved Protein Domain Family
Zip

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pfam02535: Zip 
ZIP Zinc transporter
The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.
Statistics
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PSSM-Id: 396884
Aligned: 37 rows
Threshold Bit Score: 98.9877
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q09957      4 FLFMT-TSAFAVFILLLISTSIPYTFLRTCcv------nASKTSISFLGCASCGVFIATCFLGLVPHVRHQEMHLRGNQt 76  Caenorhabditis ele...
O62192     30 DALRA-VLLIVLFALTFAAGMIATFLKGEW---------ARSHILSFISCIGGGVFLGACLLDLLPDSIESFEKTKIATe 99  Caenorhabditis ele...
Q9VEX1     53 LVAKV-TAMVVLFCASAICGSIPFLLNRCYrwtenqtnaRSAIVVKCLLYFGGGVLLATTFLHLLPEVQEVVEELQECGi 131 fruit fly
Q9LTH9     61 VLVKI-YCIIILFFSTFLAGVSPYFYR------------WNESFLLLGTQFSGGIFLATALIHFLSDANETFRGLKHKEy 127 thale cress
Q9X260      2 VLKGIlYSTIAGMATSLGALPFLFLKPHH----------TSDKVIDSFLGFAAGVMLAASAFSLVAPSLEMGGI------ 65  Thermotoga maritima
P0A8H3      5 LILTI-LAGAATFIGAFLGVLGQK---------------PSNRLLAFSLGFAAGIMLLISLMEMLPAALAAEGMSP---- 64  Escherichia coli K-12
Q9XWH3      4 ELLKW-IMLGVMALMTIIFGLLPIKVISYLnttksaihqHSSLILSLFSCFAGGVFLSVCFLDMLPDCLEAWESVQTDTn 82  Caenorhabditis ele...
Q9NP94      5 LGIKL-GCLFALLALTLGCGLTPICFKWFQida---argHHRLVLRLLGCISAGVFLGAGFMHMTAEALEEIESQIQKFm 80  human
Q9QZ03     27 LEVKL-GALVLLLLLTLICSLVPVCVLRRSganh-easaSGQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALEALh 104 house mouse
NP_650440  25 DLEKV-LAMLVLGLGSLLFGLLPAFISERNr-------rRFPLTASLLLCFGAGILLATALVHILPEVREQMDS------ 90  fruit fly
Q09957     77 ivds--------------ygwiPSTDQLVIIGFLIILITEQIIHGIGHSigng-----------------------hshS 119 Caenorhabditis ele...
O62192    100 ---------------------fPVPLAFVAVGFLLVLTIDQVVKAAKDR------------------------------N 128 Caenorhabditis ele...
Q9VEX1    132 ige----------------ltfPLAELLMCCGFFLMYFIEEAMHTYVHHhqkdeagaaferghsirnshllkptegnatT 195 fruit fly
Q9LTH9    128 ----------------------PYAFMLAAAGYCLTMLADVAVAFVAAGs----------------------------nN 157 thale cress
Q9X260     66 ----------------------VRFLIGFVLGGLFVNLADKLIPHehllkgheg-------------------------- 97  Thermotoga maritima
P0A8H3     65 ----------------------VLGYGMFIFGLLGYFGLDRMLPHAHPQdlmqksvqp---------------------- 100 Escherichia coli K-12
Q9XWH3     83 yt-----------------sdyPFVQLIALLGFFFVYLTEELSSVICNVghghshsnd-------------pimesnvtF 132 Caenorhabditis ele...
Q9NP94     81 vqnrsasernssgdadsahmeyPYGELIISLGFFFVFFLESLALQCCPG------------------------------- 129 human
Q9QZ03    105 vt-----------------lqfPLQEFILAMGFFLVLVMEQITLAYKEQtspp-----------------------hpeE 144 house mouse
NP_650440  91 ----------------------KFAEVAMCGGFFIIYFIDEFIHYFFGEaiqhthahda-----------etpatepprR 137 fruit fly
Q09957    120 GHSPLATSDSIKMNKFHDEEEGEDhvplvamdddadeii-------frqntsphhhapssGHCRTAPGGSMNIR------ 186 Caenorhabditis ele...
O62192    129 VFGHVGYHIHSHNHEHQRSEDGES------------------------------------QEEGDEAAAQSSIG------ 166 Caenorhabditis ele...
Q9VEX1    196 PTAPPAPLAGTAELGTLSVQNLLQndleqqkfatkpqqqanghghshghghghshlpviaDDADAGDMLASSLR------ 269 fruit fly
Q9LTH9    158 NHVGASVGESREDDDVAVKEEGRR------------------------------------EIKSGVDVSQALIRtsgfgd 201 thale cress
Q9X260     98 ------------------------------------------------------------------------pdtkrlkg 105 Thermotoga maritima
P0A8H3    101 ------------------------------------------------------------------------lpksikrt 108 Escherichia coli K-12
Q9XWH3    133 PRARLATVGSIFNVEGNLVEPCKR------------------------------------SLENYDDDGEGPVRq----- 171 Caenorhabditis ele...
Q9NP94    130 ----AAGGSTVQDEEWGGAHIFELh-----------------------------------SHGHLPSPSKGPLR------ 164 human
Q9QZ03    145 TRALLGTVNGGPQHWHDGPGI---------------------------------------PQAGGTPAAPSALR------ 179 house mouse
NP_650440 138 PTNDNGYGAVDERAPLLSAEPNTShghshhhshdhdhnhpas-asgcndasvedanaricHTSHTEPCAQSMTG------ 210 fruit fly
Q09957    187 VWFLLLGMSVHSFFEGVALG--VQNDSNAFWQILIAVLFHEVLCCVSYGVQLAKHNASRKYAW--TSSIFLSATIPAGMI 262 Caenorhabditis ele...
O62192    167 VAMLVLALSVHALFEGLSLA--VTSDASQLLQIFGALILHKCIMGFCLGVRLVQANLTTPWIA--LAQFLFSVQVLIGGL 242 Caenorhabditis ele...
Q9VEX1    270 GLFIVSALSLHELFEGMAIG--LESSASSVWFMFGAVSAHKLVLAFCVGVELIVARTRMLLAV--LYVLTFAVVSPLGIG 345 fruit fly
Q9LTH9    202 TALLIFALCFHSIFEGIAIG--LSDTKSDAWRNLWTISLHKVFAAVAMGIALLKLIPKRPFFLtvVYSFAFGISSPIGVG 279 thale cress
Q9X260    106 VWLFIIAITIHNFPEGMAVG--VSAFTPQALAIAIAIGVQNIPEGAAVMASLIPMKYKKGKAF--LITFLTGLVEAIGGL 181 Thermotoga maritima
P0A8H3    109 AILLTLGISLHNFPEGIATFvtASSNLELGFGIALAVALHNIPEGLAVAGPVYAATGSKRTAI--LWAGISGLAEILGGV 186 Escherichia coli K-12
Q9XWH3    172 SIIFTSAFILHVFFECFAFG--IQEDAVSVTSIFLGIAMHKAIVMFSLGMKLTRTHPRRSWIVv-ILILVLALFNVIGGT 248 Caenorhabditis ele...
Q9NP94    165 ALVLLLSLSFHSVFEGLAVG--LQPTVAATVQLCLAVLAHKGLVVFGVGMRLVHLGTSSRWAV--FSILLLALMSPLGLA 240 human
Q9QZ03    180 ACVLVFSLALHSVFEGLAVG--LQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRVQVVA--GCGILFSCMTPLGIG 255 house mouse
NP_650440 211 TLGLFVALSLHSAIEGLAIG--VQNSSTKVLFLLGAVACHKFVMGFCLGLEFRSNPQTSFRAQf-VGISVFALGAVIGIG 287 fruit fly
Q09957    263 LATTIDG---IENDMWQRIGRYWLEGLAAGTFVHVALVELL---P--MELHSDDSgegghghshnviadtthshsnhsss 334 Caenorhabditis ele...
O62192    243 AGIGIMKfisGGEQSFAAIVSSILQAIACGTFLYITTFEVI---P--HELHNGKY------------------------- 292 Caenorhabditis ele...
Q9VEX1    346 IGIL-INh--GEETSGPSLVSAILQGFACGTLIYVVFFEIL---------SKNRS------------------------- 388 fruit fly
Q9LTH9    280 IGIGINA---TSQGAGGDWTYAISMGLACGVFVYVAVNHLIskgYkpREECYFDK------------------------- 331 thale cress
Q9X260    182 LGAG--------IVSISQRLLPYMMAFAAGAMIYVVSDEVI---P---ETHSKGn------------------------- 222 Thermotoga maritima
P0A8H3    187 LAWL------ILGSMISPVVMAAIMAAVAGIMVALSVDELM---PlaKEIDPNN-------------------------- 231 Escherichia coli K-12
Q9XWH3    249 AGILISSs--NMNQTPKDITTAVLMSFSLGTFLYISFFEIL---A--PERANNHS------------------------- 296 Caenorhabditis ele...
Q9NP94    241 VGLAVTG---GDSEGGRGLAQAVLEGVAAGTFLYVTFLEIL---P--RELASPEA------------------------- 287 human
Q9QZ03    256 LGAALAEs--AGP--LHQLAQSVLEGMAAGTFLYITFLEIL---P--QELATSEQ------------------------- 301 house mouse
NP_650440 288 LGMLIVDv----PAAWSSKTLPIVQALAGGTLFYVTVCEVI---P--REKARWHSnstr--------------------- 337 fruit fly
Q09957    335 hwiSLVKSLFVAAGIGIFVIIK 356 Caenorhabditis elegans
O62192    293 ---RILKMFFIYMGFAIVVAFI 311 Caenorhabditis elegans
Q9VEX1    389 ---GLRAYLALFVGFLVMFGLQ 407 fruit fly
Q9LTH9    332 ---PIYKFIAVFLGVALLSVVM 350 thale cress
Q9X260    223 ---ELLSTWWIMVGFLVMASLD 241 Thermotoga maritima
P0A8H3    232 -----NPSYGVLCGMSVMGFSL 248 Escherichia coli K-12
Q9XWH3    297 ---NILQWIASFGGFALLAVNM 315 Caenorhabditis elegans
Q9NP94    288 ---PLAKWSCVAAGFAFMAFIA 306 human
Q9QZ03    302 ---RILKVILLLAGFALLTGLL 320 house mouse
NP_650440 338 rwaGFAQFATVLAGFATMCIIN 359 fruit fly
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