2XC7


Conserved Protein Domain Family
PHAX_RNA-bd
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pfam10258: PHAX_RNA-bd 
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Phosphorylated adapter RNA export protein, RNA-binding domain
The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterized by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains.
Links
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Statistics
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PSSM-Id: 463030
Aligned: 52 rows
Threshold Bit Score: 69.0757
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2XC7_A        11 VADEISFRLQEPKKDLIARVVRIIGNKKAIELLMETAEVEQNGG-LFIMNGS---RRRTPGGVFLNLLKNTPSISEEQIK 86 
XP_022167426 168 FLDELCTNLYEHNKILMLSVISKIDRKIILEKYKKTCLIEANGG-QMIKNGN---RRRTSGGIFFNLIKEDKSIPNSAKK 243
EFP09210     199 LGNQIADAMGEKDPDTVKKIVNAIGREVSLKLFSDTKEVEQNGG-MKITDGS---RRRTPGGVFITLFKMDSAVSREVKN 274
Q9N4E8       200 LGTQMAAAMGEKDPDTVKKITNAIGSELSIKLFNETKEIEQNGG-MKTADGS---RRRTPGGVFITLFKMDSSVSREIKD 275 Caenorhabditis ...
KRY43188     147 FSKRLAAALGERKSAYLNAIVGAIGNKKAMELYNRVVDVEMVGG-LPTKDNT---QRRTPGGVFFTFFKSDDSISSEVKL 222
EFO23104     239 LAERIVRALGERNEKFLRSVILEIGEEKALELFKATREIEASGG-MMIADGT---RRRTPGGVFMTLFKTDPDILPVLKE 314
XP_002502266 202 LAERICRRLREHKKHLVRLLIAQFGAALCEGALEETIRVEKNGGsFVTLDGAggvRRRLPGGVFIATVKS--RAPPVEFK 279
XP_006644266 110 FVNETCKRLKEKKSYLVWNAVGCLGVSVVSDLVREVEAIQKCGG-QTIADGS---RFRTGGGILWNILKS--R-EPKAYK 182
XP_006853912  88 FVTNTCRHLGEKKSYLFWEAISCLGLSVLTDLIKEVDVIQDCGG-QLTADGG---RPRTGGGILWNIIKA--R-HPTAYK 160
XP_002516471  92 FVLDVCRRLKEKKSYMVYTAVACLGVSRLGDLVKEVDAVLSCGG-QMTADGG---RFRTGGGILWNIVKT--K-EPKAYQ 164

2XC7_A        87 DIFYIENQ 94 
XP_022167426 244 DLFNCPQN 251
EFP09210     275 SIFDNMRN 282
Q9N4E8       276 GIFGDMRN 283 Caenorhabditis elegans
KRY43188     223 RIKKYDKM 230
EFO23104     315 KVCNLQKT 322
XP_002502266 280 AVMKRAAE 287
XP_006644266 183 EIMAKGRE 190
XP_006853912 161 EIVARGKE 168
XP_002516471 165 EIMKKTKE 172
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