6MCP,4J1V,7K36


Conserved Protein Domain Family
Mob1_phocein
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pfam03637: Mob1_phocein 
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Mob1/phocein family
Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.
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Statistics
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PSSM-Id: 461000
Aligned: 137 rows
Threshold Bit Score: 135.746
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6MCP_B         4 EATLGSG-NLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTi--tEFCTEASCPVMSAGpRYEYHWADgtniKKPikC 80 
XP_011406147  41 QLIRKDYkDVEAILDPPPVQDEASWKYEHLRQFCNELNS-LTVclleE-CDPLVCKQMTATeQWIFLCAAhr-qPKE--C 115
XP_026644637 363 QNIRADCsNIDKILEPPEGQDEGVWKYEHLRQFCLELNG-LAVklqsE-CHPDTCTQMTATeQWIFLCAAhk-tPKE--C 437
XP_002599458  46 QNIRQDHnNIDKILEPPEGQDEGVWKYEHLRQFCLELNG-LAVklqtE-CNPETCTQMTATeQWIFLCAAhk-tPKE--V 120
XP_015790436  43 QSIKRDPsNIDEILKPPEGQDEGTWKYEHLRQFCMDLNK-LAVklqtE-CLPSACVQMTATeQWIFLCAAhk-tPKE--C 117
EFO15553      46 QCIHKDPsDVDTILKVPPGQEEGVWKYEHVRQFCMQLNG-LTLllqdE-CKPDVCMQMTATeQWIFLCAAhk-nPKE--C 120
P34349        45 QTIKANPaDVATILTPPLDQDEGVWKYEHLRQFCIELNG-LALllqrE-CIPETCQQMTATeQWIFLCAAhk-nPNE--C 119 Caenorhabditis ...
EPB89947      46 QLIRLDYsDVQRIIELPENVDDEVWQYEHLRQVCLELSL-LVValetD-CTKQHCPEMKAd-GWLYLCAAhp-sTQS--C 119
EXX59452      71 SLIRANReNIDALVELPAGQDKETWQYEHLRQLCLELNY-LVIqleaE-CTSQTCPEMKAd-DWQYLCAAhq-aPLN--C 144
7K36_H        45 qniradcsNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKl--qSECHPDTCTQMTATeQWIFLCAAhk-tPKE--C 119

6MCP_B        81 SAPKYIDYLMTWVQDQLDDETLFPSKIGVPfPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQ------EEAHLNTSf 154
XP_011406147 116 SALDYTLHTLHGAASLLNSNKHFPSRV-SI-KENSAQKLSSVARRIYRIFSHAYCHHRTLFNDFE------EKTYLCKR- 186
XP_026644637 438 PAIDYTRHTLDGAACLLNSNKYFPSRV-SI-KESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYE------NETFLCHR- 508
XP_002599458 121 RPDSHISSTFKNSLHLPKSVGALPSVI-SI-KESSVAKLGSVCRRIYRIFSHAYYHHRNIFDEFE------NETCLCKR- 191
XP_015790436 118 PAIDYTRHTLDGASCLLNNTKYFPSRV-TM-KESSVSKLGSVCRRVYRIFGHAYFHHRSIFDEFE------NSSHLCKR- 188
EFO15553     121 SAIDYTRHTLDGAAALLNSNKYFPSRI-SI-KESSIAKIGSVCRRIYRIFSHAYFHHPELFENFE------TETHLCRR- 191
P34349       120 PAIDYTRHTLDGAATLLNSNKYFPSRV-NI-KEISISKLGSVARRVYRIFSHAFFHHRKLFDEFE------NETHLCKR- 190 Caenorhabditis ...
EPB89947     120 PAIDYIIHTLDGATILLNNSKYFPSRI-SV-PEPSLKHFQSIARRLYRIFAHAYFHHREIYESFEasleflNETYLYAR- 196
EXX59452     145 CAIDYIVHTLDGATTLLNSHKYFPSRI-SI-PETSLKHYQSIARRLYRIFAHTWFHHREIFEAFE------NENMLYAR- 215
7K36_H       120 PAIDYTRHTLDGAACLLNSNKYFPSRVSIK--ESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYE------NETFLCHR- 190

6MCP_B       155 khFIFFVQEFNLIDRRELA-PL 175
XP_011406147 187 --FTRYVIKYDLMTTDNLIvPL 206
XP_026644637 509 --FTKFVMKYNLMSKDNLIvPI 528
XP_002599458 192 --FTVFVTKYNLMSKDNLIvPI 211
XP_015790436 189 --FTIFVTKYNLMSKEHLIvPI 208
EFO15553     192 --FTVFVKKYNLMANEHLIvPI 211
P34349       191 --FTTYVSKYNLMQQEHLIvPI 210 Caenorhabditis elegans
EPB89947     197 --FLLLSQTYGLIPPSLVSipd 216
EXX59452     216 --FLKLSDRYELIAKNLLIiPY 235
7K36_H       191 --FTKFVMKYNLMSKDNLIvpi 210
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