Conserved Protein Domain Family
FAIM1

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pfam06905: FAIM1 
Fas apoptotic inhibitory molecule (FAIM1)
This family consists of several fas apoptotic inhibitory molecule (FAIM1) proteins. FAIM expression is upregulated in B cells by anti-Ig treatment that induces Fas-resistance, and overexpression of FAIM diminishes sensitivity to Fas-mediated apoptosis of B and non-B cell lines. FAIM1 is highly evolutionarily conserved and is widely expressed in murine tissues, suggesting that FAIM plays an important role in cellular physiology.
Statistics
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PSSM-Id: 462035
Aligned: 36 rows
Threshold Bit Score: 214.74
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011446217    5 VVATWQVALPDGVHDIEFEHGTTSGKRVIRVDGKEIYKV----DWMFKLVGKEHFQVGHSkaKCTITID--AVSGFAYEY 78  
EFO21490        7 TVASWSVPVQDRIYKIEFEHGTASGKRVIRVDGKEILRK----NWMFSLVGKEIFNIGKF--KCAINVE--ALGTFLYEY 78  
PDM63209        7 TVAVWHVPLQDKVHKIEFEHGTTTGRRLIKVDGKEMIRR----DWMFKLVGKEHFMLHDAi-RCTITVE--AIGTFAYEY 79  
EFO89424        6 DVILWKVPIKSTVHVVEFEHGERTGVRVLRVNGNELFRT----G-QYKITGKASFQVETL--QCRVMVK--AADPTLLMY 76  
EGT58138        5 LVAAWNIPVQAHFHKVEFDHGQTTGKRVIRVDGKEVLRR----NWIVSLTGKEDFSIGNM--KCSINIKpsPCATIDYEY 78  
XP_003099585    8 FIISWILPINNKQYKIQLEQAFVTNEIHIRVDEKEVYEHlcdvTNYFRPPDRNYFKIDGI--QCCVIIE--EPSFGVYKH 83  
XP_003094217  161 CVATWNVPLHAQVHKVEFEHGTTTGKRVIRVDGKEILRR----DWMFKLVGKENFKVGDM--KCVINVE--ALGTFAYEY 232 
EFO88279        6 RVASWNVPLRTQIHKIDFEHGTTTGKRVIRVDGVEILRR----DWMFKLVGKEVFKFGTT--HCTINVE--AIGNFAYEY 77  
EGT41210        6 VSATWTISLQKQVHKVEFEHGTTFGRRVIRVDGKEVLRR----EWMFKLVGKENFNIGKI--LCEISIE--AVGTSGYEY 77  
EGT36929        6 VVATWNVPLHKQVHKVEFEHGTTTGKRVIRIDGREILRR----DWMFKLVGKENFILGGM--QCTISVE--ALGTFAYEY 77  
XP_011446217   79 TLEVNGKSLNKFRENQSKVQKAWVLTIAGNPIRVCLEKDTLDVWVNGDKVETFGEFGEEGTETHFQIG--AHSAHITAIS 156 
EFO21490       79 TLEVNGKSYDKFREDVAKKFKSWTTVLDGQETRICLDKGTMDIWVNGQKMNTAGEFLENGTKTHFEIG--HSVCYVKATS 156 
PDM63209       80 SLEVGGKTYEKFREEQSKKLQTWHCQIGESDCRICLDKQTMDVWANGKPVETTGEFGDEGTETHFQIN--GVACKVVSVN 157 
EFO89424       77 ALKVDGKLLKDYKKEHHRRWQSWDCNIDGVEWKIDLDKSTMDIRANGIIVPTTGEFLDDETVTSFTVGvkATPCKIVAIG 156 
EGT58138       79 VLEIEGNSFVKYKQDHYERNLTWEPSLMDQKGRVVFDKGNMTLWVNGSKVETVGEFTDAGTIHHFTVG--TTPCRIVTTS 156 
XP_003099585   84 SLVVGGKAFREIKEEHYTKYDTWKPVISGKEYLVVMEKHAMNTWVDGNQIDLSRQFTDHGTVAIFHLN--GTPCKILTEC 161 
XP_003094217  233 SLEVNGKTFNKFKEEQNKKLQSWETTIAGQEWRVVLDKDSMEVWANGKNIDTAGEFVDNGNVTHFELG--TTPCKIVAVS 310 
EFO88279       78 SLTVNGKTYNKFKEEQNKKLQSWEMTIYGHDWRIVLDKDSMEIWANGNIIKKEAEFVDNGTETHFELG--TTPCRIVTIS 155 
EGT41210       78 TLHVNGKTFEKFKQEQDKKLQSWETTTGGHEWRVVLYKETMEVWANGTIIATAGEFVEGGSLTHCELN--STPCRITTKS 155 
EGT36929       78 TLDVNGKTFNKFKEELNKKLQSWETTIGGHEWRVVLDKEAMEVWANGNTVLTAGEFVDNGTLTHFELG--KTPCRIMAQS 155 
XP_011446217  157 SgRRRDGILHKLFVDDTEIPEC 178 
EFO21490      157 SgNKKFGFIYQLYVNNNEIISS 178 
PDM63209      158 SgKRSTGVVHELYLTMMFGGGA 179 
EFO89424      157 SgNIEIGIIHKLYVNNVRVPIN 178 
EGT58138      157 SgDKKTGVIHDLYVRDYRVPRF 178 
XP_003099585  162 IiGGASGMKHSFFVNN-----N 178 
XP_003094217  311 SgKRKTGVIHLFYVNGDAVPST 332 
EFO88279      156 SgDRKIGIIHQLYADDKLIPSV 177 
EGT41210      156 SgNKKTGLIHTLYVNNTIVPSK 177 
EGT36929      156 SgNKKIGVLHTLYVNNTLVPST 177 
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