Conserved Protein Domain Family
epsilon_tubulin

?
cd02190: epsilon_tubulin 
The epsilon-tubulin family
The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.
Statistics
?
PSSM-Id: 276959
Aligned: 24 rows
Threshold Bit Score: 561.861
Created: 5-Feb-2015
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative nucleotide binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the structurally resolved tubulin proteins

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                ###  ##                                                                 
AAN77278       2 TQSIVLQVGQCGNQIGCRFWDLALREHasvnkkg----------------iydealcSFFRNVdtraeagga---daqrg 62  African clawed ...
ACO63816       2 REIITVQVGQCGNQIGCRFWELALKEHaayntka----------------ryddalsSFFQNVdtrhepaiklpvgdgkg 65  Micromonas sp. ...
EPZ31138       2 AESIFVQVGQCGNQIGTRFWELALQEHahfnpsg----------------iyddemcTFFRNEkngkplp-------pqs 58  Rozella allomyc...
EEQ98388       3 REVVTIQVGQCGNQIGWRFWDLVIREHsaearrrqaqg---------qaivyddcisTFFRNLdangadipt----gces 69  Perkinsus marin...
CBY08394       2 TENVLVEVGQCGNQIGRRFWEMALAEHsaaksdt----------------vydmalsSFFRNTdsssgrel-----kvgs 60  Oikopleura dioica
KEP61046       3 REVFVVQIGQCGNQIGGQFWETLLEEHaaavareaeaskkwsrqnasyvprfnasmsTFFRNVnarhhacyd---ledgq 79  Hammondia hammondi
XP_001348899   3 REIIFLHVGQCGNQLGHEFWSVAIKEQlnkklndkkecl-------nkniflndsmsSFFFEElkennn---------cs 66  Plasmodium falc...
AAF32302       3 REVVTVQVGQCGNQLGLKWWDVLLQEHkanpqf-------------------tdardALFDVSgsaplasvg----dkac 59  Trypanosoma brucei
KDR24090       2 SEFLTVQVGQCGNQIGGAFWPLVLQEYgigtqtgcismsqs--qhidpngrlldafqSFFLSSdgisgqnfk---tladl 76  Zootermopsis ne...
BAN19872       2 SEILFIQVGQCGNQIGWKFWERALKEHqnyhkna----------------pydlsyrSFFEIGekgsf-----------d 54  Trichonympha ag...
Feature 1                    ###  #                                  ###                         
AAN77278      63 kicsLKARAVMIDMEEGVVNEil-qGPLRDLFDS---------KQLITDVSGSGNNWAVGHKLYGGQYREHIVENLRRTA 132 African clawed ...
ACO63816      66 siraLKARAVVVDMEEGVTNEll-sGPMRDVFDT---------KQFITGQSGSGNNWACGSHHYGPMYRDTLLEAVRRQA 135 Micromonas sp. ...
EPZ31138      59 rinqLKARALLVDMEEGVIVNqlnkNPIREIFDT---------QQLVSDVSGSGNNWAQGYHEYGHRYKESILNQVRIQA 129 Rozella allomyc...
EEQ98388      70 plenMRARAILVDMEQGVINQvl-nSKIGSLFRDpkrpndcrlQQCVTDVSGAGNNWAHGYYGYGETYGGSVMEKVRFAV 148 Perkinsus marin...
CBY08394      61 pissLKARAVLIDMEESVVEAsq-rSSIGELFDP---------ALSVTSQSGSGNNWAVGFYEYGSQYRPGIYEVLRHTA 130 Oikopleura dioica
KEP61046      80 plktLKARAVLIDMEEGVLNElr-rGSFGSLFDE---------RHLISDVSGAGNNWAHGFCVFGPEHRDRIAESLRRSL 149 Hammondia hammondi
XP_001348899  67 kkenLKARAILIDTETGVANEim-kSTISPYIDE---------NNIFTQQSGAGNNWSQGYMYYGKMYENIIDNIIRRNV 136 Plasmodium falc...
AAF32302      60 ragsLKARCVAVDMEEGVLRAml-rGPLGHLFDA---------TFFVSDVSGAGNNWAVGHMEYGDKYIDSITETVREQV 129 Trypanosoma brucei
KDR24090      77 enakVRARAVCIDMEDSVVAHfr-tGQFRHLFDE---------TCLLTNYPGSGNNWAEGFYAHGSEYSEKILNILQRCA 146 Zootermopsis ne...
BAN19872      55 dlntVRARAVLIDSETNVTNQlq-kSKIGNIFKG---------CAFSVDAGGAANNWAIGYHECGPNQSEPIFERIRKII 124 Trichonympha ag...
Feature 1                     #### ##                         # ##         #                     
AAN77278     133 EQCDCLQCFFVIHSMGGGTGSGLGTFVLNVLEEEFPEVy-RFVTSVYPSAe--DDVITSPYNSVLAMKELTEHADCVLPI 209 African clawed ...
ACO63816     136 EDADSLQSFLLLHSLGGGTGSGLGSYMLGALADEYPDVy-RFSVSVFPSEd--DDVVTSPYNAMLSCAALAEHADCVMPV 212 Micromonas sp. ...
EPZ31138     130 EHCDSLQSFFLLQSISGGTGSGLGSFICQTLANEYPDVm-RMCVSVFPSVe--DVVITSPYNSLLCLDTLVNYADCVFPI 206 Rozella allomyc...
EEQ98388     149 EACDSLQAFFCVNSLGGGTGSGLGSYILERLEDEYGSKayRFVSALFPTIdaeDDVITSPYNAILSLTKLRENASCVLPI 228 Perkinsus marin...
CBY08394     131 EKCDAMSSWFIIHSMGGGTGSGLGTNVLSVLADEFPDIe-RLVTPVYPSEd--DDVITSPYNSMLAMRQLTDYANSVMPV 207 Oikopleura dioica
KEP61046     150 ETAESPQGFLVLHSLGGGTGSGLGSFVVQMLEEELPDLp-RFCCSVVPSPvhvDDVVTAPYNNLLSLLHLRRHASCVLPV 228 Hammondia hammondi
XP_001348899 137 EKCDSLQSFYITSSLGGGTGSGLGSYILEMLSDTFREI--KFSNCVFPSVc--DDVITSPYNSFFALNKIHEFSNCVLPV 212 Plasmodium falc...
AAF32302     130 ERCDSIQSFLIMHSLSGGTGAGLGTRVLGMLEDEFPHVf-RICPVVMPSAi--DDVVTAPYNTAFAVRELIEHADAVLPL 206 Trypanosoma brucei
KDR24090     147 EKSDQLHGFLCLFSLGGGTGSGLGSSILTILEDNFPLIe-RFVTCVYPAGn--EDVVTAPYNVALATRELTHHASCVFPV 223 Zootermopsis ne...
BAN19872     125 ERSNKVESFFMLNSLGGGTGSGFGSYLLEHLVDLYPKIw-KLSSVVTPTGd-dSHVVTSPYNCALAASHLCQYSDCVFPI 202 Trichonympha ag...
Feature 1         #                                                 #  ##  #                     
AAN77278     210 ENQSLVdivnkinqmantgklgnv--------kpnslvtsskggvkenekPFDAMNNIVANLLLNLTSSARFEGSLNMDL 281 African clawed ...
ACO63816     213 ENQALMdivtsiqskslgsqrgss--------lsgldsgdvggraghggkPWDGMNGIAANLLLNLTAGMRFDGSLNVDI 284 Micromonas sp. ...
EPZ31138     207 ENKCLLsicdkmnsikdak------------------ntlagpqkkdkraTFDDMNSIVANLLLNLTCSMRFNGELNVDL 268 Rozella allomyc...
EEQ98388     229 SNDALArivntynasaalvng--------------atqkggggmfskkqtSFDDMNSIVARCWLDLTASMRFEGSLNVDL 294 Perkinsus marin...
CBY08394     208 DNSSLAditnrvkaas-------------------------nnsnndkktSWGEMNSLVAQSILNVTSSCRFPGSLNVDL 262 Oikopleura dioica
KEP61046     229 SNDALVkmcaeqrptpvrpdtfd----------plcvwharrrlspgdicAFAEMNAIVAQTLSHLTSSLRYEGSLNVDL 298 Hammondia hammondi
XP_001348899 213 SNDALLnilnskklreidktvkn-----------nninsvndkntsivknDYSKMNNIVANVILNLTSSMRFEGSLNVDI 281 Plasmodium falc...
AAF32302     207 DNDALArmadsalgqktigqaagerkepqttlgapaargysvaqptqtklPYDSMNALVAQLLSNLTCAMRFPGPLNMDI 286 Trypanosoma brucei
KDR24090     224 DNKALSdicsrlksskdk---------------------hgvagyiaackPFQDMNSIVVNMLLHLTSGSRFPGSMNVDI 282 Zootermopsis ne...
BAN19872     203 ENTSLQnfvhgv--------------------------------ekgtsgAFDQMNGVVANFLMDLTAGSRFHGKMNVDL 250 Trichonympha ag...
Feature 1                                                                                        
AAN77278     282 NEISMNLVPFPQLHYLTSSLTPLytladv-------nvpsrrLDQMFSDAFSKDHQlirad----pkhsLYLACALMVRG 350 African clawed ...
ACO63816     285 NEITTNLVPFPKLHFLLSSMSPVavsadrgr----nipaprtMDQIFTEVFGRDRQlasvd----prrsTYLACALMLRG 356 Micromonas sp. ...
EPZ31138     269 NEISSNLVPFPKLHFLLTSMAPLfkpak---------lqplrTDQLFNDLFQREFMlvdtn----pkahTYLASAVICRG 335 Rozella allomyc...
EEQ98388     295 NEITSNLVPFPNTHFLLPALSPIfqrskdv------rlqprsFDHMFSDAFLPGSQlvgsgagvdprasLSLASAFLLRG 368 Perkinsus marin...
CBY08394     263 NEITMNLVPFPRMHYLTTCLSPLflskd----------lnlpICCYVDLVYSGTHAlvggd----prrsVLAASALIARG 328 Oikopleura dioica
KEP61046     299 EDICTNLVPFPGLHFLLASLPSSaqpree-------tslaraFSQSFSALLSPAHQlfach----pkrsLCLAAAFLVRG 367 Hammondia hammondi
XP_001348899 282 NEICTNLIPYPFFNFLLSSLSPCiese-----------sirtFDHLFKNVLSQNNQmlian----pkdgLSLSMAFLVRG 346 Plasmodium falc...
AAF32302     287 NEITTNLVPYPRLLFLTSAIAPLsvarhaaasaprsvdtmiaACLDKNHQFVDVSNglssal--theagTCLATAIVARG 364 Trypanosoma brucei
KDR24090     283 NEIYNNMVPYPGLHYISSSISPLlfqts----------ssttTDDLFTSAWSRDNQllkvd----plsgIVLGASLLGRG 348 Zootermopsis ne...
BAN19872     251 LEIKTNLIPFPNHKFLVSGMSPIiatn-----------sprnINGFFQESMSAKATlcdid----plkgTVLSSALLIRG 315 Trichonympha ag...
Feature 1                                                                                        
AAN77278     351 -NVQISDLRRNIERLKPSLQFVSWNQ-EGWKTGLCSVppvghsHSLLALANNTCVKPTFIELRDRFSKLYRKKAHLHHYL 428 African clawed ...
ACO63816     357 -GVNISDANRNVERLRRGLKMAHWVS-DGFKVGLCDRapvgtpYSALCLANNCAMQRPLDAMNERFGKLRKRNVYLHHYT 434 Micromonas sp. ...
EPZ31138     336 -NFTLTDIRRSIDKLKRQLRFVDWNQ-DGWKVGHCSNpsllseRTVLSISNNTSIASTFEGIESRFLKLYRRKAHLYHYL 413 Rozella allomyc...
EEQ98388     369 -ECSLNDVNRNVSRIKKTLNRPAYLD-DCYKIGICNV------YSLLSLVNSCGIRPVFEKMHANFWRLYKRKAHVHHYT 440 Perkinsus marin...
CBY08394     329 -KIELSDMRRNISRLAKQLQFVNWNQ-DGWKVGLCSVapsgqpFSLLGLHNSTSILPTFTALRSRFSKLYRRKAHLHHYN 406 Oikopleura dioica
KEP61046     368 aDISVSDLLNNIARVRRSLKVLSGNE-DATKIGLCAVaplgqpYGLLGLSNSCEATHLFSSVHERFDKLFKRKAHLHHYE 446 Hammondia hammondi
XP_001348899 347 -NINISDVTKNVLLIKNNLNILKYNK-DATKIGICNVsplnqpYSLLCLINSCEIRNTFLQILERFNKLFKRKAHLHHYL 424 Plasmodium falc...
AAF32302     365 pQITVGDLTRNIPRIRERQKLVYWNE-DGCKTALCSVsplghrNSVLMLANHCSIAQKLQSAHERFMRLYSVRSHVHHYE 443 Trypanosoma brucei
KDR24090     349 -SISVSDMRRNIDKFQTKVKFVPWSCgDAMKIGLCSVpppglaSSVLSLINTSNMSSLFKDVSQKFTKLYQRKAHVHHYL 427 Zootermopsis ne...
BAN19872     316 -NIGLSTVRSNIDKLAKQINFLPWNK-DGWKIGICNNpplysdISINCLTNTSSICKIFDVMIERFDRLFKSKAYLQHYT 393 Trichonympha ag...
Feature 1                                   
AAN77278     429 qvdgMEQHCFTEAISSLSSLIEEYSQL 455 African clawed frog
ACO63816     435 e--yMDLADIDGAAECIQDLGAEYGRL 459 Micromonas sp. RCC299
EPZ31138     414 e--fMENDHFNSALDNIQNLIEQYKKY 438 Rozella allomycis CSF55
EEQ98388     441 e--yMDQDVFEEARHTLRFMMDDYTEE 465 Perkinsus marinus ATCC 50983
CBY08394     407 hvdgFDSNMFQEALHSIDDVIAQYQSV 433 Oikopleura dioica
KEP61046     447 q--yMDLDMFAEASESVLDLASSYAFL 471 Hammondia hammondi
XP_001348899 425 e--yLSMDDILEFKEKIQNLIFEYSYI 449 Plasmodium falciparum 3D7
AAF32302     444 p--yLEQAYFDDTCDTVLTVVDDYNYL 468 Trypanosoma brucei
KDR24090     428 qvpgFNEEDFASSLENLHKLEEEYTKL 454 Zootermopsis nevadensis
BAN19872     394 q--hMSLEEMKAVKETILFMKDEYKEM 418 Trichonympha agilis

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap