Conserved Protein Domain Family
bHLH_TS_HEN1
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cd19701: bHLH_TS_HEN1 
basic helix-loop-helix (bHLH) domain found in helix-loop-helix protein 1 (HEN-1) and similar proteins
HEN-1, also termed nescient helix-loop-helix 1 (Nhlh1), or Class A basic helix-loop-helix protein 35 (bHLHa35), or nescient helix loop helix 1 (NSCL-1), is a neuron-specific bHLH transcription factor that may serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.
Links
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Statistics
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PSSM-Id: 381544
Aligned: 11 rows
Threshold Bit Score: 117.066
Created: 3-Aug-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        #   # ### #    #                 ####                   
Q02575        61 LSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 132 human
NP_989452     58 LSREERRRRRRTTAKYRTAHATRERIRVEAFNMAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 129 chicken
XP_006001924  57 LSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 128 coelacanth
NP_001081852  56 LTREERRRRRRATTKYRTAHATRERIRVEAFNLAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 127 African clawed frog
NP_476989     94 LSREERRRRRRATLKYRTAHATRERIRVEAFNVSFAELRKLLPTLPPDKKLSKIEILKLAICYIAYLNHVLE 165 fruit fly
ESO83335      41 LSREERRRRRRATQKYRTAHATRERVRVEAFNVAFSDLRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLE 112 owl limpet
PIK48774      49 LTREERRRRRRATAKYRTAHATRERIRVEAFNAAFGELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 120 Japanese sea cucumber
ELT99031      73 ITREERRRRRRATEKYRTAHATRERVRVEAFNVAFSELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 144 Capitella teleta
XP_019631149  90 LSREERRRRRRATAKYRTAHATRERIRVEAFNVAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 161 Belcher's lancelet
XP_006812839  37 LTREERRRRRRATAKYRTAHATRERIRVEAFNVAFGELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 108 Saccoglossus kowalevskii
XP_007889785  47 LSREEKRRRRRATAKYRTAHATRERIRVEAFNVAFAELRKLLPTLPPDKKLSKIEILRLAICYISYLNHVLD 118 elephant shark

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