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PKc_like: Protein Kinases, catalytic domain
The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-speci...
View in Cn3D
PH-like: Pleckstrin homology-like domain
The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-bindi...
SH2: Src homology 2 (SH2) domain
In general, SH2 domains are involved in signal transduction; they bind pTyr-containing polypeptide l...
FERM_F1: FERM F1 ubiquitin-like domain
This is an F1 lobe domain consisting of a ubiquitin like fold found in FERM region of Jak-family tyr...
FERM_F2: FERM F2 acyl-CoA binding protein-like domain
This is an F2 lobe domain consisting of an acyl-CoA binding protein fold found in FERM region of Jak...
View in Cn3D Specific ProteinProteinSuperfamilySuperfamily MembersPubMed
FERM_C_JAK1: FERM domain C-lobe of Janus kinase 1
JAK1 is a tyrosine kinase protein essential in signaling type I and type II cytokines. It interacts ...
PTK_Jak1_rpt1: Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 1
Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, includ...
PTKc_Jak1_rpt2: Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1
PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in prot...
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