1NFD,1TVD,1AO7,1BD2,1D9K,1FYT,1MI5,1OGA,1YMM,1YPZ,2ESV,2EYR,2F53,2IAL,2NW2,2P5E,2Z35,2AK4


Conserved Protein Domain Family
IgV_TCR_alpha
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cd04983: IgV_TCR_alpha 
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins
The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.
Links
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Statistics
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PSSM-Id: 409372
Aligned: 32 rows
Threshold Bit Score: 121.224
Created: 21-Sep-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1NFD; human alpha/beta T-cell receptor (TCR) alpha chain IgV domain forms interface with beta chain IgV domain, contacts based on 3.5 A distance.
    - View structure with Cn3D
  • Comment:Human alpha/beta T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                       # #    #  #  #                                
1NFD_A      3 VTQTEgLVTVTEGLPVKLNCTYQtt-ylTIAFFWYVQYLneAPQVLLKSst--------dNKRTEhqgFHATLHkssSSF 73  Mus musculus
1FYT_D      3 VTQLGsHVSVSEGALVLLRCNYSss--vPPYLFWYVQYPnqGLQLLLKYts-------aaTLVKGingFEAEFKkseTSF 73  human
2Z35_A      3 VTQTGgQVALSEEDFLTIHCNYSas--gYPALFWYVQYPgeGPQFLFRAsr-------dkEKGSSr-gFEATYNkeaTSF 72  house mouse
CAB39547    9 SIQDS-PVQALQGDGVTLSCNYSs----ATYFFWYRQYPssHPQFLIKEy----------MELSRf-tLRKDSDk--KMF 70  Atlantic cod
AAM21520   19 INSKEeYISRRIGENVTLTCEYSts-stTPYLFWYRQYPn-QIEYLLYRgaksysnlkhdGNYGKg-kFDSIANd--IST 93  African clawed frog
AAM21531   23 VEQTHqPQSILQGTSVYLECTYKis--gSANVFWYVQYPrqTPEMLLSSl----------LNEENk-gFSAEHKrseTSF 89  African clawed frog
AAN33119   33 VIQQEgQVTVEQGNTFQTNCTYEts--nFNGLLWYQQKKgqAPQLITRQag--------aGTKQKd-rLTTELNterKSS 101 mallard
AAR18380   23 VVQFAqETAIQVGHNATLHCNFSts-tiSPYILWYQQHLtqSPQFLLQVsk-------fkPHVHSe-rISSVLSmenSQV 93  mallard
AAR84218   25 STEED-RVSATEGESVTLRCSYSttassSVYLYWYRQYPgrGPEYILERgargs-tyantAAFAKe-rFSSTATd--DST 99  Australian echidna
CAM73248   24 VEQPLrDITANEGDQVIIPCNYStt-dtNPYLFWYKQLPnkSPTFILNKltyg---egtvEADFKe-rFSATLNstaKSV 98  zebrafish

Feature 1                  # #           #   # #       
1NFD_A     74 HLQKSSAQLSDSALYYCALSEGg---nYKYVFGAGTRLKVI 111 Mus musculus
1FYT_D     74 HLTKPSAHMSDAAEYFCAVSESpf-gnEKLTFGTGTRLTII 113 human
2Z35_A     73 HLQKASVQESDSAVYYCALSENyg--nEKITFGAGTKLTIK 111 house mouse
CAB39547   71 HLEISAAAVTDSALYYCAAMNQg----QKILFGAGTNLLVK 107 Atlantic cod
AAM21520   94 QLIIFSLTVEDSALYLCALSDAeqsggYKLTFGGGTELTVQ 134 African clawed frog
AAM21531   90 HLKKDKAELQDSGVYFCAVSETss--nWKIIFGKGTKLNVY 128 African clawed frog
AAN33119  102 VLHLKEVELSDSALYFCSVSDVsgssyGKLTFGSGTRLSVQ 142 mallard
AAR18380   94 LLHVQDAKLQDSAVYLCALSPSsg-slNKPTFGSGTRLSVL 133 mallard
AAR84218  100 SLSIRELSLSDTATYYCALRDSgs-sqNKLIFGTGTQLLVR 139 Australian echidna
CAM73248   99 PLMIKDAQLSDSAVYYCALRTSgs-gaYKLFFGTGTKLIVE 138 zebrafish

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