6GML


Conserved Protein Domain Family
COBRA1

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pfam06209: COBRA1 
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Cofactor of BRCA1 (COBRA1)
This family consists of several cofactor of BRCA1 (COBRA1) like proteins. It is thought that COBRA1 along with BRCA1 is involved in chromatin unfolding. COBRA1 is recruited to the chromosome site by the first BRCT repeat of BRCA1, and is itself sufficient to induce chromatin unfolding. BRCA1 mutations that enhance chromatin unfolding also increase its affinity for, and recruitment of, COBRA1. It is thought that that reorganization of higher levels of chromatin structure is an important regulated step in BRCA1-mediated nuclear functions.
Statistics
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PSSM-Id: 461851
Aligned: 13 rows
Threshold Bit Score: 532.735
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GML_V       104 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTElSVLHN 183 human
EKC25449     105 KSLRPVVMAILKHLPQIKDEYLEKILDDKELYAEAATEVKRQIWSDNQALFGDEVSPLLSQYIKEKENSLFSHE-NSAQT 183
EDO30397      98 KELRPVVVAVMKHLPKINDECLEHIANDAKLYEDCPIEVKRQIWSKHHHLFGDAVGPLLNQYIEAKYTLLHSTEaHNSHS 177
XP_015794791 105 QTLQPIVMSLLKNLERIDDKYLKQIVADRELYEKCDLSVKRQIWQQHQGLFGDEVSPLFSAYIKEKDTMLFSLQ---SGS 181
XP_001951169 118 KQLRPIIMAILKNISHIDDKYLNVLVKDTELYKDTDTEVKRQIWKDNQSLLVNEVSPLLTQYIREKENILFDHN-NLTNL 196
XP_004933406 113 KALRPVIMGILKNIPHIDDKYLRVLVRDRELYNDTDTEVKRQIWQDNQSLFGDEVSPLLSQYIREKEDVLFDHE-NLTNL 191
XP_002424304 102 KQLRPVVMCILRNTPHIDDKYLNILVRDRELYSDTDTEVKRQIWRDNQSLFGDEVSPLLSQYIQDKENILFDHL-NLNNL 180
Q16FI1       113 KALRPVVMCILRNTSHIDDKYLRILVRDRELYQDTDTEVKRQIWRDNQSLFGDEVSPLLSQYIREKEHILFDHM-NLNNL 191 yellow fever mo...
XP_002609285 123 PTLRPVVMHVMKHINNIPEDYLKKLLEDPNLYKESATEVKRQIWRNNQSLFGDEVSPLLSQYIKEKDTLLFSLEpANSNN 202
XP_003455080 106 PSIQPVVMQVLKHLPKVPEKKLKMVMADKELYKVCAVEVKRQIWQDNQALFGDEVSPLLKQYIVEKEAALFSSDlSILHN 185
XP_002130034 104 DSLVPVSMCLLKHLPKVPEKYISVLTKDKSLYSACPIQVKRQIWQKNQTIFGDEVLPLLTRYIKEKEVVLLDGEcLEGNN 183
1_pfamImport   1 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYIVEKESALFSTElSVLHN 80 
XP_023350174 107 PSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKENILFSNEvSVLHN 186 Tasmanian devil
6GML_V       184 FFSPSPKTRRQGEV---VQRLTRMVGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDVGEICTVDPCH- 257 human
EKC25449     184 FYLASPKLRRQSEV---VQRLADMVGKNVKLYDMVLQFLRTL--FLRTRNMHYCTLRAELLMALHDQEVNDICSIDPCH- 257
EDO30397     178 FFSVPSKTRRQHAI---VQGLAKMIGKSLSLYNLVLQFLRTL--FLRANEVHYCTLRSELLMAVHDLEVKDIKDVDPCH- 251
XP_015794791 182 FFAMTPKQRRQSEI---IQNLVKIIGRNVLLYDTCLQFLRTL--FLSTKNSHYCTLRVDLLMALHDADIQDITSMDPCH- 255
XP_001951169 197 FFTPSPKLRRQGEV---VQKLAHMIGSSVKLYDMVLQFLRTL--FLRTHNVHYCTLRAELLMALHDLEIQDIISIDPCH- 270
XP_004933406 192 FFSPSPKVRRQGAV---VQKLAHMIGTSVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMALHDLEVQDIISVDPCH- 265
XP_002424304 181 FFSSSPKIRRQSEV---VQKLAHMIGTSVKLYDMVLQFLRTL--FLRTSNVHYCTLRAELLMALHDLEIQDIISVDPCH- 254
Q16FI1       192 FFTPTPKVRRQGEV---VQKLAHMIGNSVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMALHDLEVQDIISVDPCH- 265 yellow fever mo...
XP_002609285 203 FFTPAPKSRRQGEV---VQKLMHMIGRDVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMALHDTEVHEICSVDPCH- 276
XP_003455080 186 FFSPSPKTRRQGEV---VLKLTQMIGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDISEICSVDPCH- 259
XP_002130034 184 FFTSSPKSRRQGHV---VKTLTEMIGKNIRLYDMVLQFLRTL--FLKTHNVHYCSLRSEMLMSLHDLEVTEVCTVDPCY- 257
1_pfamImport  81 FFSPSPKTRRQGEXpppPHRLQGLSVRSLRASRTALLLLGSAspLLQSPREH--THLTSFLHCLASGDAQLWPSPDPAFs 158
XP_023350174 187 FFSPSPKTRRQGEV---VQKLTQMIGKNVKLYDMVLQFLRTL--FLRTRNVHYCTLRAELLMSLHDLDISDICMVDPCH- 260 Tasmanian devil
6GML_V       258 -KFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLALST-------VRHLQELVGQETLP 329 human
EKC25449     258 -KFTWCVDACIRDKFIDSKRSRELQGFLDGIRRGQEFVLGDLSMVLCDPFSMNTVGLSM-------MRNLQHCLNNESLP 329
EDO30397     252 -KFTWCLDACIREKSIEGKRVRELQGFLEMAKNGEERVLGDIAMILCDPFAINTIAKSI-------IKLLHRLANTDTLP 323
XP_015794791 256 -KFAWCLDACIREQNIDPKRSRELQGFLEGVKRGQEQVIGDLSMTLCDPYAVNFLANKA-------IKIANNLINNENLA 327
XP_001951169 271 -KFTWCLDACIRERNVDVKRSRELQGFLDSIKRGHETVLGDLSMTLCDPYAINFLATST-------IRILHHLINNENLP 342
XP_004933406 266 -KFTWCLDACIRERNVDIKRSRELQGFLDSIKKGQEQVLGDLSMTLCDPYAINFLATSA-------IKILQHLINTEGLP 337
XP_002424304 255 -KFTWCLDACIREKSVDIKRSRELQGFLDSIKRGQEQVLGDLSMTLCDPYAINFLAQSA-------IKILQHLIHNEALP 326
Q16FI1       266 -KFTWCLDACIREKNVDIKRSRELQGFLDNIKRGQEQVLGDLSMTLCDPYAINFLATSA-------IKILQHLINNEGLP 337 yellow fever mo...
XP_002609285 277 -KFTWCLDACIRERFIDAKRARELQGFLDGVKRGQEQVLGDLSMILCDPYAVNTVASSS-------LKVLQHLVAQESLP 348
XP_003455080 260 -KFTWCLDACIREKFVDGKRARELQGFLDGVKKGQEQVLGDLSMILCDPFACNTLVLSI-------MRNLQELLSQDALP 331
XP_002130034 258 -KFTWCLDACIREHYVDVKRARELQGFLDNVRKGHEQVLGDLSMILCDPFAVNTMLWSV-------MKIIHELTVKETLP 329
1_pfamImport 159 pQFTWCLDACIRERFVDSKRARELQGLQEGWLPGQ---------WLCGPRAALADAVGAvffpawlVKHLQELVGQEVLP 229
XP_023350174 261 -KFTWCLDACIREKFVDNKRARELQGFLDGVKKGQEQVLGDLSMILCDPFAINTLSLST-------IRHLQELVGQETLP 332 Tasmanian devil
6GML_V       330 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKL--------------PAEEK 395 human
EKC25449     330 RDSSEIVLLVRMMGLGLGSWDMIDSQLFREPKLESSLFTKFLPMISSLMVEDHTRVLSAKL--------------PEEPP 395
EDO30397     324 RTSEDITFLLRLLNLGVSAWDMIEKQAFKEIPVNDELASKFLPFIMSLMVDSSLNTLNGKV--------------PEDDI 389
XP_015794791 328 RENLVLMLILRMLNLGLHSWDILNSQVYREPKLDVELVTRFLPVLMSLIVDDQVRAVNSKL--------------PPDDR 393
XP_001951169 343 RENHVLVLLLRMLSLGLSAWVMIDTQDFKEPKLDSQVVTKFMPALMSLMVDDQVRALNTKM--------------PPDER 408
XP_004933406 338 RDSTVLILLLRMLALGLSAWVMIDSQEFKEPKLDSQCVTKYLPALMSLMVDDQVRALHNKL--------------PPDER 403
XP_002424304 327 RDNTVLILLLRMLALGLSAWYMIDTQEFKEPKLDCQVVTKFMPALMSLMVDDQVRTLNSKL--------------PPDER 392
Q16FI1       338 RDNTILILLLRMLALGLSAWIMIDSQDFKEPKLDSQVVTKFLPALMSLMVDDQVRNLHAKL--------------PPDER 403 yellow fever mo...
XP_002609285 349 RDSPELSLLLRMLSLGLGAWEMIDSQVFKEPKPDNEVITKFLPALMGLMVEDQVRLVAKKL--------------SENHK 414
XP_003455080 332 RDSPDLMLLLRMLSLGQGAWDMIDSQVFKEPRLDLEVVTRFLPAMMSVVVDDHTFTVEQKL--------------PSEEK 397
XP_002130034 330 RESTELMLLIRMLKLGQSAWDIINKQIFKEPKVDVDISNKFIPCMVCIGVCEQSVLLRNKVknlrksvadcdvttPDDDQ 409
1_pfamImport 230 RDSPDLLLLLRLLALGQGAWDMIDSQVFKEPKMEVELVTRFLPMLMSFVVDDHTFNVDQKL--------------PAEEK 295
XP_023350174 333 RESPDLLLLLRMLSLGQGAWDMIDSQVFKEPKMEAELITRFLPMLMSFVVDDYTFNVDQKL--------------PTEEK 398 Tasmanian devil
6GML_V       396 APvs----yPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVE 447 human
EKC25449     396 LS-------ATPPSDL-------------FLTFVKENPIASFTTLYYSLQVTRMKDRVAACNIIPVLVH 444
EDO30397     390 EEglv--sdGRHLAHH-------------FMHMMVSNKVAFKLAWCFMLHLLHQKDKAAVFHALPWYVS 443
XP_015794791 394 ESaltiiehSGPPPDL-------------YQKFITEDRLATELAIYYTLQVLRQKDRNAVVRVLGFLSN 449
XP_001951169 409 ESaitiiehSGPVPDA-------------VQAYIQESSVACTVAMYYTLHVAKAKDRLALMRILGSLAN 464
XP_004933406 404 ESaittiehSGPPPDA-------------CEAYMRESSVCGVIAMYYTLHAAKLRDRGALLRILSILGS 459
XP_002424304 393 ESaitiiehSGPAPDA-------------CQAYVTESSVASILAMYYTIHTAKLKDKVGLMRVLGILAT 448
Q16FI1       404 ESaittiehSGPAPDA-------------VEAYIQESAVASILAMYYTLHTARQKDRVGILRVMAILAS 459 yellow fever mosquito
XP_002609285 415 NS---------TIPKT-------------FAKSIRQHGIAAILTLYYLYNVTKHRNKDAIMHIIPKMTD 461
XP_003455080 398 SSls----yPTTLPES-------------FNRYLQENRVACEMGLYYVLHIAKLRNKNALQRLLPALVE 449
XP_002130034 410 SKkkskpkkAADIGDEsndketssttinyIHKHIEKDQLCRIILMWFTLHLVKNKRKTQLIQVLPILGK 478
1_pfamImport 296 APvt----yPNTLPES-------------FTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLAT 347
XP_023350174 399 ASvt----yPNTLPES-------------FIKFLQEHRMACEMGLYYVLHITKQRNKNAFLRLLPGLVE 450 Tasmanian devil
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