Conserved Protein Domain Family
SH3BP5

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pfam05276: SH3BP5 
SH3 domain-binding protein 5 (SH3BP5)
This family consists of several eukaryotic SH3 domain-binding protein 5 or c-Jun N-terminal kinase (JNK)-interacting proteins (SH3BP5 or Sab). Sab binds to and serves as a substrate for JNK in vitro, and has been found to interact with the Src homology 3 (SH3) domain of Bruton's tyrosine kinase (Btk). Inspection of the sequence of Sab reveals the presence of two putative mitogen-activated protein kinase interaction motifs (KIMs) similar to that found in the JNK docking domain of the c-Jun transcription factor, and four potential serine-proline JNK phosphorylation sites in the C-terminal half of the molecule.
Statistics
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PSSM-Id: 461608
Aligned: 20 rows
Threshold Bit Score: 236.026
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:MICPUN_62998 237 EEVDPRVAGALDEMNEAMMSVNDAETALAAAKRRRRAHKAEGSQKIEETRKKLS-SSVRAAVPFFHAQAVAHMYQVRSIE 315
Q21194            33 TRHLNMIHEELEKLNISTDVINKMEVQLDLARADFRETQVQWSEKLKELSKQYS-SQIAKARPFYELKIKERSLREESQK 111 Caenorhabdi...
2_pfamImport       1 ---MMSIRRQLENLNDATDDINSYEMKLEHVKKQFCETQLIFNREISGIPNKLA-KHISKARPFFDLKSREPNLRRFAQQ 76 
Q9V785             7 GELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLG-NCIEKARPYYEALDKAREAQIECQK 85  fruit fly
XP_008198596       7 NELDPRIQIELEKLNTTTDEINRLEIEYDEANTTFRMLLNESTRRLKILSKKLG-SCIERARPYYEALEIAKKAQQECQK 85 
XP_001952650      30 DSLDPRIQLELEKLNSSTDNINKLEIELDEANTTFRMLMAEASRRLKVRARKLG-SCIDKARPFYDALNMSKHSQQQCQI 108
EKC38135         226 tlvrsQNREELNVLNQTSADINKLENELDEARGNYKIIFTEASERLAQAAEKRR-KPIQRARAYFELKEEAKRAQGESLK 304
XP_001746898     283 EEVDPRVEIALQDMNDASDAINRLEKELEETKAAFKTAMDQVQIDLRDLANKLGrRNIDKARPYHQALFRARKAHYESRQ 362
XP_004365456     284 EIADPRIKGALEALNFATEEINRLERELEASKRTLRVLDRDGAKQLLALAQKLG-KAVDRSRAYYNLKHEASEAHRLAIE 362
CAF99475          18 EEVDPRIQGELEKLNQSTDDINRWESELEDGRQRFRAVLVEAMCKLDGLMKRIG-RAVDDSKPYWEARKVAKQAQIEAQK 96 
jgi:MICPUN_62998 316 CLRAYEKAHDMHAAAKESAAQLEAEMAssaspgkkitgnEGGTFDTDLMIALSDAMSKVVETEIMKKRAEGAHGRMTKLA 395
Q21194           112 AAERFERATSILGIAKQQVSLTQESLS------------RQTSVLPECLEVLNHHIQRVREVEEERTAAESLHASKAHAM 179 Caenorhabdi...
2_pfamImport      77 AAALFERQKTVVEMAREQLTILHSSLNn----------nDEMDAEKKYIDVIEQQLELVNEAEAECAEAERAHAARVRDL 146
Q9V785            86 AAVKFQRANEIHAAAKETVALAEQRFMsn---------sHEWQFDNAWQEMLNHATQKVMDAETQKADCHAEHQRLTKLF 156 fruit fly
XP_008198596      86 AAVQFQRANEIHAAAKETVALAEQRFLsn---------qHEWQFDNAWQEMLNHATIKVMEAENQKAESGREHQRRATIF 156
XP_001952650     109 AAVKYQRANEIHQAAKETVALAEARFLsk---------qHEWKFDSAWQEMLNNAIQKVTEAENQKTESGREHQRKAALY 179
EKC38135         305 AARQYQSAISVYRAAKETVTLAEERLLq----------nGEGNLSAAWQEMMNHATMRVMDAEKEKRESEERHQLATTKC 374
XP_001746898     363 AAVYFEKASGAYQQAKQKVKATEQQLE------------KGATFDANLQASLNKATQDLMTAFNRKEHADTIHQTKTQTF 430
XP_004365456     363 AAKTFEKACSAHDAAKERLAKAERHVLt-----------DNKKIDPVWHDMMATAATQVIESENAKRDASTTHQALLSAA 431
CAF99475          97 ATQEFQRSVEILRAAKETIALAEERLLe----------eDSRQFDSAWQEMLNHATQRVMEAEQSRTRSEAEHKKTAANY 166
jgi:MICPUN_62998 396 TTAVNESMALRKKIAKSVEKAQPYFAVKSSVEAKARALEEEVVDVEKRVKEMKRRYHAAMDELAKISDEVHARRLREKEE 475
Q21194           180 LHLAEKIRAMEKDNRYAIKKSRLYFEKRLEFTKILEAQKATILCLEAEVRQKKNDYTTSLRNLERISERIHEERSTGSLE 259 Caenorhabdi...
2_pfamImport     147 LQLETTLRRLLQENGPSIKKARPYYDRKEVLTKTMNSQIELMSILENEVQDRKDSYSTSMRALEQISEQIHQERSSQNSL 226
Q9V785           157 NAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPT- 235 fruit fly
XP_008198596     157 KTAEDCVKQLESRLQKSIIKSRPYFDEKSLCQQQLNTQKDRIETIKRDIVKTKSSYAQTLKQLEQISNEIHMKRGSVTED 236
XP_001952650     180 QAAEQKVQMLEQKFKRSIIKSRPYFEEKYLCEGQLAAQKDTIIQIRYAVQRAKQEYSACLHRLEQISEEIHVQRQNNKLM 259
EKC38135         375 ANCEKKLKQLEKRFSKSIQKAGPYFEVKQQLDIKLQHQKQNVTDLQSAIKDTKAKYSNALRNLEKISEEIHQSRRDKIML 454
XP_001746898     431 LKADRELMELAKARKKIIIKTKPYYESKVQHDKILMGLRQQLLQQERDIKAAKEKYSNSLNTLSSISEEIHERREAEKAA 510
XP_004365456     432 AHVSTKLEAAARDIKPRIAKAKPYYDLQNELREQRTKLVDKQTFLAEEIALAKRHVQYSLSNLNDISMEIHEQRRARKAE 511
CAF99475         167 NSSISHMRQLEKKLKRSINKSRPYFELKGKYYLQLEHLKILVNERQAKLMSAKAEYRKALRNLESISEEIHAQRRSVAMG 246
jgi:MICPUN_62998 476 RE 477
Q21194           260 SA 261 Caenorhabditis elegans
2_pfamImport         --    
Q9V785           236 -P 236 fruit fly
XP_008198596     237 IL 238
XP_001952650     260 EC 261
EKC38135         455 MF 456
XP_001746898     511 kt 512
XP_004365456     512 as 513
CAF99475         247 TR 248
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